Decoding the genome of SARS-CoV-2: a pathway to drug development through translation inhibition

RNA Biology, Год журнала: 2024, Номер 21(1), С. 1 - 18

Опубликована: Дек. 4, 2024

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the disease 2019 (COVID-19) pandemic and is continuously spreading globally. continuous emergence of new SARS-CoV-2 variants keeps posing threats, highlighting need for fast-acting, mutation-resistant broad-spectrum therapeutics. Protein translation vital replication, producing early non-structural proteins RNA replication transcription, late structural virion assembly. Targeted blocking viral protein thus a potential approach to developing effective anti-SARS-CoV-2 drugs. SARS-CoV-2, as an obligate parasite, utilizes host's machinery. Translation-blocking strategies that target mRNA, especially those its conserved elements are generally preferred. In this review, we discuss current understanding translation, important motifs structures involved in regulation. We also through degradation or element dysfunction.

Язык: Английский

The battle between infectious bronchitis virus and innate immunity: a mini review

Virology, Год журнала: 2024, Номер 603, С. 110321 - 110321

Опубликована: Ноя. 29, 2024

Язык: Английский