Lycium barbarum Polysaccharide Alleviates Amyloid‐β‐Induced Toxicity in the Caenorhabditis elegans Model DOI Creative Commons
Lu An, Wenbo Wang,

Jihao Chu

и другие.

Food Frontiers, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

ABSTRACT Alzheimer's disease (AD) poses a significant global health challenge, primarily characterized by the aggregation of β‐amyloid (Aβ) peptides and associated oxidative stress. Given lack effective AD drugs, we investigated effects Lycium barbarum polysaccharide (LBP), water‐soluble from goji berries, on Aβ scavenging, aggregation, Aβ‐induced toxicity using transgenic nematode. LBP treatment delayed paralysis, mitigated chemotaxis deficits, reduced 1–42 deposition oligomer formation in nematodes. Furthermore, supplementation alleviated stress improved resistance through insulin/insulin growth factor 1 (IGF‐1) signaling (IIS) pathway. Evaluation clearance pathway revealed that attenuated increasing proteasome activity rather than lysosomal levels. Basic physiological assessments further indicated was non‐toxic vivo promoted nematode health. Our findings suggest ameliorates AD‐like symptoms nematodes activating IIS to reduce enhancing proteasomal clear aggregates, providing new theoretical basis for considering as promising therapeutic drug related complications.

Язык: Английский

Synthesis, Characterization, Molecular Docking, and Computational Study of novel Spirothiazolidinone Compounds DOI
Mohammed G. Mukhlif,

Omar J. Mahdi,

Mustafa J. Bichan

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер unknown, С. 141517 - 141517

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Synthesis and corrosion inhibition efficiency of Schiff bases derived from salicylideneaniline – a review DOI

Sana Almi,

Z. Rais,

Saida Seridi

и другие.

New Journal of Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This review examines the properties of Schiff bases, derived from salicylideneaniline compounds, in preventing corrosion various metals.

Язык: Английский

Процитировано

0
A novel avenue in the successful synthesis of Schiff base macromolecules via innovative plasma and classical approaches DOI Creative Commons
Rawda M. Okasha, Abdel‐Aleam H. Mohamed, Ahmed A. Elhenawy

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 29, 2025

Schiff base macromolecules have been successfully synthesized, utilizing a classical chemistry route and dielectric barrier discharge (DBD) plasma technique. The synthesis of monomeric units has accomplished through typical reactions aldehyde amine functional molecules. condensation polymerization the molecules instigated chemically, using p-toluene sulfonyl chloride in refluxed ethanol. molecular weight obtained polymers was discovered to be 524, 664 1,503,228 for 4a 4b, respectively. Additionally, were prompted, employing Dielectric Barrier Discharge atmospheric pressure air DBD demonstrated very powerful routine produce high weights with optimum condition at 5 min. duration time, which could an ecofriendly strategy acquire this class materials. new polymeric materials characterized FTIR NMR spectroscopy. Moreover, complexation polymer 4b various metal moieties, Ru (II), Co Cu Ni executed order comparative study their antitumor activity against MCF-7, HCT-116, HepG-2 cell lines. Furthermore, density theory exploited optimize complexes, HOMO-LUMO energy gap calculated, utilized examine inter/intra charge transfer. electrostatic potential map similarly quantified investigate reactive sites that are present investigated result docking confirmed these complexed adopted numerous important interactions amino acid targeted enzyme.

Язык: Английский

Процитировано

0
Lycium barbarum Polysaccharide Alleviates Amyloid‐β‐Induced Toxicity in the Caenorhabditis elegans Model DOI Creative Commons
Lu An, Wenbo Wang,

Jihao Chu

и другие.

Food Frontiers, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

ABSTRACT Alzheimer's disease (AD) poses a significant global health challenge, primarily characterized by the aggregation of β‐amyloid (Aβ) peptides and associated oxidative stress. Given lack effective AD drugs, we investigated effects Lycium barbarum polysaccharide (LBP), water‐soluble from goji berries, on Aβ scavenging, aggregation, Aβ‐induced toxicity using transgenic nematode. LBP treatment delayed paralysis, mitigated chemotaxis deficits, reduced 1–42 deposition oligomer formation in nematodes. Furthermore, supplementation alleviated stress improved resistance through insulin/insulin growth factor 1 (IGF‐1) signaling (IIS) pathway. Evaluation clearance pathway revealed that attenuated increasing proteasome activity rather than lysosomal levels. Basic physiological assessments further indicated was non‐toxic vivo promoted nematode health. Our findings suggest ameliorates AD‐like symptoms nematodes activating IIS to reduce enhancing proteasomal clear aggregates, providing new theoretical basis for considering as promising therapeutic drug related complications.

Язык: Английский

Процитировано

0