Virus Research,
Год журнала:
2025,
Номер
unknown, С. 199572 - 199572
Опубликована: Апрель 1, 2025
Porcine
epidemic
diarrhea
virus
(PEDV)
is
the
major
agent
of
recent
outbreaks
in
piglets,
which
has
caused
huge
economic
losses
to
global
swine
industry.
Since
traditional
vaccine
strategies
cannot
provide
complete
protection
for
development
safe,
effective,
and
economical
antiviral
drugs
urgently
needed.
For
many
years,
Chinese
medicines
(TCMs)
have
been
broadly
applied
viral
infectious
diseases,
exhibiting
advantages
such
as
abundant
resources,
lower
toxicity,
minimal
drug
resistance.
Many
herbal
monomers,
single
extracts
derived
from
these
drugs,
recipes
exhibit
significant
anti-PEDV
effects
vitro
and/or
vivo
by
targeting
multiple
sites
perspectives,
including
inhibition
life
cycle,
anti-inflammation
effects,
enhancement
host
immune
response,
modulation
reactive
oxygen
species,
apoptosis.
However,
date,
no
review
published
on
TCM.
Therefore,
this
summarizes
current
control
PEDV
systematically
analyses
research
progress
TCMs
against
PEDV.
Furthermore,
future
directions
integration
nanotechnology
artificial
intelligence
with
are
also
discussed.
This
will
a
valuable
reference
studies
research.
Critical Reviews in Biotechnology,
Год журнала:
2025,
Номер
unknown, С. 1 - 19
Опубликована: Янв. 6, 2025
This
comprehensive
review
aims
to
explore
and
consolidate
the
current
knowledge
on
dendrobine,
including
its
biological
activities,
molecular
mechanisms
of
action,
effects
various
physiological
processes,
potential
toxicity,
safety
considerations,
in
order
unlock
full
applications.
Dendrobine
has
diverse
effects,
anti-inflammatory,
antioxidant,
neuroprotective,
immunomodulatory,
anticancer
effects.
also
exerts
neuroprotective
by
boosting
neuronal
survival,
reducing
neuroinflammation,
regulating
neurotransmitter
release.
immunomodulatory
that
control
immune
cell
function
modify
immunological
responses.
exhibits
properties
decreasing
tumor
angiogenesis
metastasis,
causing
apoptosis
cancer
cells,
inhibiting
growth.
discusses
idea
a
circular
economy
produce
researching
cutting-edge
sustainable
methods
maximize
resource
efficiency
reduce
environmental
Additionally,
supporting
principles
for
production
outlining
future
study
areas,
this
discovery
will
help
use
dendrobine
variety
applications
while
preserving
environment.
Future
research
should
focus
advancing
application
personalized
medicine,
exploring
green
bioproduction
methods,
ensuring
ethical
sourcing
practices.
An
enhanced
understanding
synergistic
therapies
could
revolutionize
healthcare,
whereas
conservation
efforts
safeguard
ecological
impact.
Frontiers in Molecular Biosciences,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 14, 2025
Purpose
To
explore
the
phytochemical
composition
of
Schleichera
oleosa
bark
and
evaluate
its
potential
antimalarial
activity
through
in
vitro
silico
analyses.
Methods
The
S.
was
subjected
to
Soxhlet
extraction
using
petroleum
ether,
chloroform,
methanol.
quantitative
analysis
extracts
performed
determine
total
phenolic,
flavonoid,
tannin
contents.
Advanced
analytical
techniques
such
as
Gas
Chromatography-Mass
Spectrometry
(GC-MS)
Liquid
(LC-MS)
were
employed
identify
175
phytoconstituents
from
methanolic
extract
In-vitro
assessed
against
Plasmodium
falciparum
candle
jar
method,
measuring
parasite
growth
inhibition.
inhibitory
concentration
(IC50)
values
calculated
compared
with
standard
drugs,
chloroquine
quinine.
Furthermore,
computational
analyses,
including
molecular
docking
dynamics
simulations,
conducted
interactions
identified
phytochemicals
key
malarial
targets
(1CEQ
4ZL4).
efficacy
these
compounds
drugs
like
artesunate
chloroquine.
Additionally,
ADMET
(Absorption,
Distribution,
Metabolism,
Excretion,
Toxicity)
profiling
drug-likeness
assessments
performed.
Results
exhibited
promising
in-vitro
an
average
IC50
value
0.780
μg/mL,
which,
while
higher
than
(0.020
μg/mL)
quinine
(0.268
μg/mL),
still
demonstrated
significant
efficacy.
GC-MS
LC-MS
analyses
phytoconstituents,
among
which
two
novel
lead
compounds,
scillarenin
4-[(Z)-(6-hydroxy-3-oxo-1-benzofuran-2(3H)-ylidene)
methyl]
phenyl
beta-Dglucopyranoside,
highest
scores
favorable
profiles.
Molecular
simulations
confirmed
strong
binding
affinities
targets,
surpassing
some
Conclusion
This
study
reports,
for
first
time,
bioactive
constituents
derived
.
beta-D-glucopyranoside,
antiplasmodial
activity,
validating
traditional
medicinal
claims.
findings
highlight
a
source
agents
fewer
side
effects
existing
therapies.
Further
vivo
studies
are
warranted
confirm
results
support
development
new
drugs.
groundbreaking
discovery
contributes
growing
evidence
supporting
role
plants
drug
discovery.
Plants,
Год журнала:
2025,
Номер
14(5), С. 755 - 755
Опубликована: Март 1, 2025
This
review
highlights
the
recent
advancements
in
extraction
techniques
for
bioactive
compounds
from
natural
sources,
focusing
on
methodologies
that
enhance
both
efficiency
and
sustainability.
Techniques
such
as
pressurized
hot
water
(PHWE),
solid-state
fermentation
(SSF),
ionic
liquids
(ILs),
electrohydrodynamic
(EHD)
methods
have
shown
significant
potential
improving
yields
while
preserving
bioactivity
of
target
compounds.
These
innovative
approaches
offer
advantages
over
traditional
methods,
including
reduced
energy
consumption,
minimal
environmental
impact,
ability
to
extract
thermosensitive
PHWE
EHD
are
particularly
effective
extracting
antioxidants
compounds,
whereas
SSF
provides
an
environmentally
friendly
alternative
by
valorizing
agro-industrial
waste.
Ionic
liquids,
although
promising
complex
phytochemicals,
face
challenges
related
scalability
economic
feasibility.
The
adoption
these
advanced
represents
a
shift
toward
more
sustainable
cost-effective
processes,
promoting
discovery
utilization
high-value
also
contribute
development
eco-friendly,
strategies
align
with
green
chemistry
principles
regulatory
standards.
However,
further
research
technological
required
address
existing
limitations
ensure
widespread
application
industrial
pharmaceutical
sectors.
New Journal of Chemistry,
Год журнала:
2024,
Номер
49(3), С. 1053 - 1061
Опубликована: Дек. 12, 2024
The
advantages
of
using
Camellia
sinensis
extract
in
nanoparticle
synthesis,
including
eco-friendliness,
cost-effectiveness,
biocompatibility,
enhanced
stability,
and
improved
morphological
electrochemical
performance.
