Organics,
Год журнала:
2024,
Номер
5(4), С. 450 - 471
Опубликована: Окт. 24, 2024
The
triazole
scaffold
is
a
crucial
component
of
heterocyclic
chemistry,
serving
as
basic
building
block
in
organic
synthesis,
materials
science,
and
medicinal
chemistry.
Triazole
five-membered
ring
composed
three
nitrogen
atoms
two
carbon
atoms,
it
exists
isomeric
forms:
1,2,3-triazole
1,2,4-triazole.
Compounds
featuring
the
are
important
heterocycles
known
for
their
diverse
biological
activities,
including
antimicrobial,
antiproliferative,
antimalarial,
anticonvulsant,
anti-inflammatory,
antineoplastic,
antiviral,
analgesic,
anticancer
properties.
As
result,
derivatives
have
attracted
significant
attention
from
researchers.
This
review
aims
to
provide
thorough
overview
published
studies
on
synthesis
derivatives,
highlighting
various
methods
obtaining
moiety.
These
include
classical
approaches
well
microwave
ultrasound-assisted
techniques.
Korean Journal of Chemical Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 8, 2025
Abstract
Phenolic
compounds
are
a
new
class
of
Carbonic
Anhydrase
inhibitors
(CAIs).
Despite
numerous
advancements
in
treatment
approaches,
cancer
continues
to
be
growing
health
problem
worldwide.
In
our
study,
we
tested
the
effects
4-hydroxy-3-methoxyacetophenone
(1)
,
doxycycline
hydrochloride
(2)
5,7-dichloro-8-hydroxyquinoline
(3)
methyl
3,4,5-trihydroxybenzoate
(4)
2-hydroxy-4-methylacetophenone
(5)
6-hydroxy-4-methylcoumarin
(6)
and
2,5-dihydroxyacetophenone
(7)
on
Achetylcholynesterase
(AChE),
Butrycholynesterase
(BChE),
Human
anhydrase
I
(hCA
I)
enzymes.
The
U2OS
human
osteosarcoma
cell
line
was
used
determine
anticancer
potential
these
phenolic
compounds.
proliferation
colony
formation
were
analyzed
using
Neutral
Red
Uptake
(NRU)
assay
clonogenic
assay.
K
i
values
arachidonoyl
dopamine,
2,4,6-trihydroxybenzaldehyde,
3,4-dihydroxy-5-methoxybenzoic
acid
203.80,
1170.00,
910.00
mM,
respectively,
for
hCA
I,
75.25,
354.00,
1510.00
II
II).
Additionally,
IC
50
from
vivo
studies
found
range
173.25
1360.00
mM
CA
II,
CO
2
-hydratase
activity
methods.
NRU
results
revealed
that
had
dose-dependent
cytotoxic
effect
cells.
cells
determined
>
100,
93.7,
81.4,
26.9,
53.1,
100
µM,
respectively.
Notably,
compound
with
lowest
value,
significantly
suppressed
at
5
10
µM
concentrations.
These
demonstrated
could
inhibit
approximately
30%
CO2-hydratase
total
enzyme
rat
erythrocytes.
Furthermore,
suggests
molecules
pave
way
development
approaches
treatment.
activities
seven
studied
compared
against
AChE
(PDB
ID:
4M0E),
BChE
5NN0),
2CAB),
E3
ubiquitin-protein
ligase
4HG7)
proteins.
binding
free
energy
molecule
highest
docking
score
is
computed
MM/GBSA
techniques.
Finally,
molecular
dynamics
simulations
performed
between
4M0E
protein
over
0–200
ns
interval.
Graphical
abstract
Advances in chemical and materials engineering book series,
Год журнала:
2025,
Номер
unknown, С. 155 - 202
Опубликована: Янв. 3, 2025
Click
chemistry
is
not
a
single
specific
reaction,
but
was
meant
to
mimic
nature,
which
also
generates
substances
by
joining
small
modular
units.
The
1,3-dipolar
azide,
alkyne
cycloaddition
(CuAAC)
reaction
catalyzed
copper,
as
nearly
quantitative
and
easy
execute
has
emerged
the
leading
example
of
“click
chemistry”.
Given
importance
triazole
scaffold
in
medicinal
chemistry,
its
synthesis
attracted
attention
drug
discovery
development
community.
This
book
chapter
will
summarizes
major
synthetic
methods
currently
used
for
preparation
pharmacological
significance
such
antifungal,
antibacterial,
antitubercular,
anticancer,
anti-inflammatory,
antioxidant
many
more
properties
discussed.
Furthermore,
this
comprise
literature
from
2020
till
date
Russian Chemical Reviews,
Год журнала:
2025,
Номер
94(4), С. RCR5160 - RCR5160
Опубликована: Апрель 1, 2025
The
stereochemistry
of
tautomeric
functionalized
azoles
is
a
challenge
for
theoretical
research,
since
the
correct
interpretation
chemical
behaviour
and
biological
activity
these
compounds
depends
on
understanding
factors
that
determine
structural
features
relative
stability
their
tautomers.
Due
to
physicochemical
properties,
1,2,3-
1,2,4-triazoles
are
most
promising
research
objects
in
various
fields
ranging
from
medicine,
bioorganic
chemistry
agrochemistry
materials
science.
This
review
first
in-depth
analysis
data
structure
stereochemical
1,2,3-triazoles
(their
carbaldehydes,
carbaldehydoximes,
barbiturates
malononitriles),
model
analogues,
as
well
related
compounds,
obtained
by
combined
methods
based
multipulse
multinuclear
1H,
13C,
15N
29Si
NMR
spectroscopy
quantum
calculations.
<br>
bibliography
includes
320
references.
RSC Advances,
Год журнала:
2025,
Номер
15(18), С. 14499 - 14517
Опубликована: Янв. 1, 2025
A
series
of
fused
tetrahydrochromeno
isoindole
dione
derivatives
was
successfully
synthesized.
In
silico
physicochemical,
pharmacokinetic,
and
ADMET,
UV-visible
fluorescence
study
all
synthesized
compound
has
been
carried
out.
