Nanotoxicology: developments and new insights DOI

Henry N. Abonyi,

Ikechukwu Emmanuel Peter, Akachukwu Marytheresa Onwuka

и другие.

Nanomedicine, Год журнала: 2024, Номер 20(2), С. 225 - 241

Опубликована: Дек. 26, 2024

The use of nanoparticles (NPs) in treatment diseases have increased exponentially recently, giving rise to the science nanomedicine. safety these NPs humans has also led nanotoxicology. Due a dearth both readily available models and precise bio-dispersion characterization techniques, nanotoxicological research obviously been constrained. However, ensuing years were notable for emergence improved synthesis methods tools. Major advances made linking certain physical variables, paralleling improvements size, shape, or coating factors resulting physiological reactions. Although significant progress contribution development nanotoxicology, however, it faces numerous difficulties technical constraints distinct from those conventional toxicological assessment as attempts improve therapeutic effects medicines. Determining thorough standards, standardizing dosimetry, assessing kinetics ions dissolving enhancing accuracy vitro-in vivo correlation efficiency, defining restrictions on exposure protection are some most important pressing concerns. This article will explore past advancement potential prospects standard models, emphasizing findings earlier studies examining current challenges, insight way forward.

Язык: Английский

Unveiling the Role of JAK2/STAT3 Signaling in Chemoresistance of Gynecological Cancers: From Mechanisms to Therapeutic Implications DOI
Tianxiao Zhang,

Chang Xiaohan

Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104712 - 104712

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Nanotoxicology: developments and new insights DOI

Henry N. Abonyi,

Ikechukwu Emmanuel Peter, Akachukwu Marytheresa Onwuka

и другие.

Nanomedicine, Год журнала: 2024, Номер 20(2), С. 225 - 241

Опубликована: Дек. 26, 2024

The use of nanoparticles (NPs) in treatment diseases have increased exponentially recently, giving rise to the science nanomedicine. safety these NPs humans has also led nanotoxicology. Due a dearth both readily available models and precise bio-dispersion characterization techniques, nanotoxicological research obviously been constrained. However, ensuing years were notable for emergence improved synthesis methods tools. Major advances made linking certain physical variables, paralleling improvements size, shape, or coating factors resulting physiological reactions. Although significant progress contribution development nanotoxicology, however, it faces numerous difficulties technical constraints distinct from those conventional toxicological assessment as attempts improve therapeutic effects medicines. Determining thorough standards, standardizing dosimetry, assessing kinetics ions dissolving enhancing accuracy vitro-in vivo correlation efficiency, defining restrictions on exposure protection are some most important pressing concerns. This article will explore past advancement potential prospects standard models, emphasizing findings earlier studies examining current challenges, insight way forward.

Язык: Английский

Процитировано

0