Antioxidant, and enzyme inhibition effects of chia (Salvia hispanica) seed oil: A comprehensive phytochemical screening using LC-HR/MS

Electronic Journal of Biotechnology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Determination of the Inhibitory Potential of Chalcones on Myeloperoxidase Enzyme Activity: In vitro and Molecular Docking Studies

Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Язык: Английский

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Molecular Docking Studies and Biological Activities of Chalcones Targeting Acetylcholinesterase, and Carbonic Anhydrase Isoenzymes

Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, Год журнала: 2025, Номер 28(2), С. 335 - 350

Опубликована: Март 20, 2025

Chalcone molecules are important pharmacophores in medicinal chemistry and have various biological functions, including inhibitory effects on the enzymes carbonic anhydrase (CA) acetylcholinesterase (AChE). Carbonic I II inhibitors used treatment of disorders such as retinal cerebral edema (CAI), epilepsy, glaucoma (CA II). Furthermore, inhibitors, which were originally created to treat Alzheimer's disease, proven useful for patients suffering from Parkinson's disease-related memory problems, behavioral disorders, cognitive decline. The drugs market adverse effects. Therefore, new drug candidates required address issues raised. In this study, chalcone compounds synthesized investigate their CA AChE chemical structures confirmed using NMR. acetylcholine esterase presented first time study. anhydrases 1-21 investigated described methodologies. As a result studies, it was determined that inhibition range 2.65-82.33 µM hCA 2.63-74.89 II, while IC50 values reference AZA 46.75 (hCA I) 38.25 Moreover, these inhibited 15.53-177.46, value Tacrin measured 25.78 nM. Among derivatives, compound 5 emerged most potent inhibitor AChE, 13 strongest II. AutoDock Vina docking results showed had affinity (-8.0 kcal mol⁻¹) (-7.0 mol⁻¹), (-8.1 mol⁻¹). Key interactions with catalytic residues suggest halogen methoxy groups enhance enzyme binding, stability, hydrogen bonding. These findings hold promise potential related disorders.

Язык: Английский

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Some Novel Oxirane-Thiirane Derivatives: Synthesis, Molecular docking and Enzymatic Inhibition for Therapeutic Potential

Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Язык: Английский

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Guanylhydrazone and semicarbazone derivatives as potential prototypes for the design of cholinesterase inhibitors against Alzheimer's disease: biological evaluation and molecular modeling studies

Chemico-Biological Interactions, Год журнала: 2025, Номер unknown, С. 111515 - 111515

Опубликована: Апрель 1, 2025

Язык: Английский

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Comprehensive Insights into Carbonic Anhydrase Inhibition: A Triad of In vitro, In silico, and In vivo Perspectives

Enzyme and Microbial Technology, Год журнала: 2025, Номер 189, С. 110657 - 110657

Опубликована: Апрель 17, 2025

Язык: Английский

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