A Stability Indicating RP‐HPLC Method for Determination of Foslevodopa and Foscarbidopa in Bulk and Formulation DOI

Ravisankar Panchumarthy,

Srilakshmi Bathula,

Bhagavan Rajesh Babu Koppisetty

и другие.

Separation Science Plus, Год журнала: 2025, Номер 8(5)

Опубликована: Май 1, 2025

ABSTRACT The recently approved combination of foslevodopa and foscarbidopa by the United States Food Drug Administration provides a major advancement in treatment Parkinson's disease. This therapy helps to maintain consistent plasma levels levodopa, thereby minimizing overall symptom patients. A robust validated RP‐HPLC method has been developed due novelty drug its recent approval regulatory agencies. optimized chromatographic conditions included use C18 column (250 × 4.6 mm, 5 µm), an isocratic mobile phase acetonitrile: 0.1% formic acid (30:70), flow rate 1.0 mL/min, injection volume 10 µL, detection at 272 nm, ambient temperature 25°C, with total runtime 6 min. Under these conditions, eluted 2.087 min 4.166 System suitability parameters, including plate count, tailing factor, %RSD, were within acceptable limits. exhibited high precision, %RSD values below 2%, excellent linearity over concentration range 30–180 µg/mL for 1.5–9 foscarbidopa. Sensitivity analysis determined LOD LOQ 0.480 1.700 0.024 0.084 foscarbidopa, respectively. Degradation studies confirmed stability indicating capability under various stress oxidative causing highest degradation. was applied assay pharmaceutical formulation confirming compliance label claims.

Язык: Английский

Dancing Towards Stability: The Therapeutic Potential of Argentine Tango for Balance and Mobility in Parkinson’s Disease DOI Creative Commons

Federica Giorgi,

Daniela Platano, Lisa Berti

и другие.

Diseases, Год журнала: 2025, Номер 13(3), С. 82 - 82

Опубликована: Март 13, 2025

Background: Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by motor impairments, including balance deficits, gait disturbances, and postural instability. Given the limitations of pharmacological treatments, alternative rehabilitative strategies such as Argentine Tango (AT) have been explored for their potential benefits in improving mobility quality life individuals with PD. This systematic review evaluates effectiveness AT enhancing balance, gait, functional PD patients. Methods: A literature search was conducted across PubMed, Cochrane Central Register Controlled Trials (CENTRAL), Scopus, PEDro, Web Science. Studies were included if they randomized controlled trials (RCTs) assessing impact on outcomes Data extraction risk bias assessment performed independently two reviewers using Risk Bias 2 (RoB 2) tool. Results: Five included, sample sizes ranging from 10 to 62 participants intervention durations varying weeks 24 months. significantly improved (Mini-BESTest, BBS, FRT), performance (6MWT, TUG), compared usual care or conventional exercise. Some studies also reported psychological benefits, reduced depressive symptoms increased confidence. However, freezing inconclusive, methodological limitations, small inconsistent durations, noted. Outcomes (FoG) remained inconclusive due variability methods reporting studies. Conclusions: appears be an effective rehabilitation strategy While preliminary evidence suggests additional larger, high-quality are needed confirm its long-term efficacy establish standardized protocols. may integrated into multimodal programs enhance psychosocial management. heterogeneity limit generalizability findings. serve structured approach could community-based clinical programs.

Язык: Английский

Процитировано

0
Neuroprotective effect of cedrol in a male rat model of Parkinson's disease DOI Creative Commons
Fatemeh Forouzanfar, Mahmoud Hosseini, Amir Mahmoud Ahmadzadeh

и другие.

Physiological Reports, Год журнала: 2025, Номер 13(7)

Опубликована: Апрель 1, 2025

Abstract Cedrol is a natural sesquiterpene subgroup of terpenes with antioxidant and anti‐inflammatory properties. This study evaluated the effect cedrol on 6‐hydroxydopamine (6‐OHDA) rat model Parkinson's disease (PD). Unilateral injection 6‐OHDA was performed to induce PD model. at 10 mg/kg 20 administrated. The rotarod test, apomorphine‐induced rotational open field tests assessed motor function, while passive avoidance test used evaluate cognitive function. Furthermore, striatal levels malondialdehyde (MDA) total thiol, SOD (superoxide dismutase) activity were measured. induction lesion led significantly higher number rotations in lower maintenance as well shorter delay for entering into longer duration time spent dark chamber versus control group. It also enhanced MDA diminished level thiol. Administration improved behavioral biochemical assays. could benefit functions PD. Its properties might mediate these effects.

Язык: Английский

Процитировано

0
Parkinson’s Disease Detection Using InceptionV3: A Deep Learning Approach DOI Creative Commons

M S Pallavi,

Madhwesh Bayari,

G Abhilash

и другие.

MethodsX, Год журнала: 2025, Номер unknown, С. 103333 - 103333

Опубликована: Апрель 1, 2025

Parkinson's disease (PD) is a neurodegenerative condition that progressively affects motor function and causes tremors, rigidity, bradykinesia. Detection of PD at an early stage important to ensure timely intervention better patient outcomes. This study uses deep learning algorithms classify spiral images traced by patients as inexpensive diagnostic technique for the detection PD. A database consists drawn manually normal individuals, divided into training testing sets. To discriminate between drawings Parkinsonian healthy cases four Convolutional Neural Network (CNN) architecture like DenseNet121, InceptionV3, VGG16, LeNet are used. Followed transfer which employed improve model performance extracting fine impairment patterns in spirals. DenseNet121 InceptionV3 achieve competitive with 98.44 % accuracy, whereas VGG16 demonstrates excellent feature extraction performance. The emphasizes relevance non-invasive diagnosis, consistent, efficient, automated method detection. future can be directed towards combination other biomarkers or broader data set measures wider assessment.•The focuses on enhancing features leveraging hybrid models, improving classification performance.•Implementation scaling leads performance, improved accuracy.•The comparative analysis CNN provides valuable insights balancing computational efficiency

Язык: Английский

Процитировано

0
Polymer nanocomposite-based biomolecular sensor for healthcare monitoring DOI

Bharathi Natarajan,

Palanisamy Kannan,

Govindhan Maduraiveeran

и другие.

Advances in Colloid and Interface Science, Год журнала: 2025, Номер 343, С. 103557 - 103557

Опубликована: Май 15, 2025

Язык: Английский

Процитировано

0
A Stability Indicating RP‐HPLC Method for Determination of Foslevodopa and Foscarbidopa in Bulk and Formulation DOI

Ravisankar Panchumarthy,

Srilakshmi Bathula,

Bhagavan Rajesh Babu Koppisetty

и другие.

Separation Science Plus, Год журнала: 2025, Номер 8(5)

Опубликована: Май 1, 2025

ABSTRACT The recently approved combination of foslevodopa and foscarbidopa by the United States Food Drug Administration provides a major advancement in treatment Parkinson's disease. This therapy helps to maintain consistent plasma levels levodopa, thereby minimizing overall symptom patients. A robust validated RP‐HPLC method has been developed due novelty drug its recent approval regulatory agencies. optimized chromatographic conditions included use C18 column (250 × 4.6 mm, 5 µm), an isocratic mobile phase acetonitrile: 0.1% formic acid (30:70), flow rate 1.0 mL/min, injection volume 10 µL, detection at 272 nm, ambient temperature 25°C, with total runtime 6 min. Under these conditions, eluted 2.087 min 4.166 System suitability parameters, including plate count, tailing factor, %RSD, were within acceptable limits. exhibited high precision, %RSD values below 2%, excellent linearity over concentration range 30–180 µg/mL for 1.5–9 foscarbidopa. Sensitivity analysis determined LOD LOQ 0.480 1.700 0.024 0.084 foscarbidopa, respectively. Degradation studies confirmed stability indicating capability under various stress oxidative causing highest degradation. was applied assay pharmaceutical formulation confirming compliance label claims.

Язык: Английский

Процитировано

0