Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 140601 - 140601
Опубликована: Ноя. 1, 2024
Язык: Английский
Drug Development Research, Год журнала: 2025, Номер 86(3)
Опубликована: Май 1, 2025
ABSTRACT Coptisine, an isoquinoline‐based phytochemical, exhibits a broad spectrum of biological activities, including anticancer and anti‐inflammatory properties. Its planar chemical structure allows for the induction effects by forming telomeric G‐quadruplex structures. Despite its promising medicinal benefits, clinical utilization this compound is limited critical shortcomings such as low efficacy poor pharmacokinetics. While in vitro studies demonstrate high cytotoxicity, vivo research highlights favorable toxicity profile, attributed to conversion iminium form less toxic alkanolamine within physiological setting. Past endeavors have focused on rectifying these limitations through structural modifications yield more efficacious molecules. In current review, we provide overview properties coptisine semisynthetic derivatives, conjunction with pharmacokinetic synthesis, safety/toxicity considerations. This review draws upon information sourced from publications indexed esteemed scientific databases like Web Science, PubMed, Scopus, among others. To prepare each section, utilized Coptisine section‐specific keywords, emphasizing recent literature findings (2014–2024) while maintaining scope due study's nature. conclusion, underscores coptisine's remarkable properties, suggesting that further exploration may derivatives enhanced profiles, pharmacokinetics, therapeutic potential.
Язык: Английский
Процитировано
0
Опубликована: Июль 13, 2024
The reaction of berberine derivatives containing at O-9 position N,N-disubstituted acetamide fragments with sodium borohydride in methanol 0 °C leads to a mild reduction the "C" cycle formation corresponding tetrahydroberberine moderate good yields.
Язык: Английский
Процитировано
1
Pharmacological Research - Modern Chinese Medicine, Год журнала: 2024, Номер unknown, С. 100522 - 100522
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
1
African Journal of Pharmacy and Pharmacology, Год журнала: 2024, Номер 18(6), С. 96 - 102
Опубликована: Июль 24, 2024
Язык: Английский
Процитировано
0
Molbank, Год журнала: 2024, Номер 2024(3), С. M1865 - M1865
Опубликована: Авг. 13, 2024
The reaction of berberine derivatives containing at the O-9 position N,N-disubstituted acetamide fragments with sodium borohydride in methanol 0 °C leads to a mild reduction “C” cycle formation corresponding tetrahydroberberine moderate good yields.
Язык: Английский
Процитировано
0
The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(17), С. 12853 - 12857
Опубликована: Авг. 27, 2024
A one-pot access to the protoberberine and tetrahydroprotoberberine scaffold has been developed from easily available primary amine-functionalized o-alkynylbenzaldehydes. The core skeleton of was afforded via in situ generation isochromenylium by Ag(I) catalysis, subsequent cyclization isoquinolinium, final hydride reduction a continuous operation procedure. newly step-economic protocol shows excellent regio- stereoselectivity is capable achieving those previously unavailable derivatives/analogues with electron-deficient substituents, providing robust tool for medicinal investigations protoberberines derivatives.
Язык: Английский
Процитировано
0
Phytotherapy Research, Год журнала: 2024, Номер unknown
Опубликована: Сен. 19, 2024
ABSTRACT Oxidative stress plays an important role in the occurrence of neurodegenerative diseases. Previous studies indicate a strong connection between oxidative stress, inappropriate activation p38 MAPK signaling pathway, and pathogenesis Although antioxidant therapy is valid strategy to alleviate these problems, most limitation this approach ineffectiveness drug administration due limited permeability BBB. Therefore, BBB‐penetrating modulators with proper capacity could be useful preventing/reducing complications disorders. The current manuscript aims review therapeutic capabilities some recently reviewed naturally occurring inhibitors management problems such as Alzheimer's disease. In data collection, we tried use more recent published high‐quality journals indexed databases Scopus, Web Science, PubMed, so on, but no specific time frame was considered nature study. Our evaluations that natural compounds tanshinones, protoberberines, pinocembrin, osthole, rhynchophylline, oxymatrine, schisandrin, piperine, paeonol, ferulic acid, 6‐gingerol, obovatol, trolox have significant potential for supplements/adjuvants reduction neurodegenerative‐related problems. findings emphasize usefulness phytochemicals modulatory activity options against Of course, depends on considering their toxicity/safety profile pharmacokinetic characteristics well clinical conditions users.
Язык: Английский
Процитировано
0
Journal of Molecular Structure, Год журнала: 2024, Номер unknown, С. 140601 - 140601
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
0