Journal of Colloid and Interface Science, Год журнала: 2024, Номер 683, С. 58 - 67
Опубликована: Дек. 21, 2024
Язык: Английский
Biosensors, Год журнала: 2024, Номер 14(7), С. 356 - 356
Опубликована: Июль 22, 2024
The steady progress in consumer electronics, together with improvement microflow techniques, nanotechnology, and data processing, has led to implementation of cost-effective, user-friendly portable devices, which play the role not only gadgets but also diagnostic tools. Moreover, numerous smart devices monitor patients' health, some them are applied point-of-care (PoC) tests as a reliable source evaluation patient's condition. Current practices still based on laboratory tests, preceded by collection biological samples, then tested clinical conditions trained personnel specialistic equipment. In practice, collecting passive/active physiological behavioral from patients real time feeding artificial intelligence (AI) models can significantly improve decision process regarding diagnosis treatment procedures via omission conventional sampling while excluding pathologists. A combination novel methods digital traditional biomarker detection portable, autonomous, miniaturized revolutionize medical diagnostics coming years. This article focuses comparison modern techniques AI machine learning (ML). presented technologies will bypass laboratories start being commercialized, should lead or substitution current Their application PoC settings technology accessible every patient appears be possibility. Research this field is expected intensify Technological advancements sensors biosensors anticipated enable continuous real-time analysis various omics fields, fostering early disease intervention strategies. integration health platforms would predictive personalized healthcare, emphasizing importance interdisciplinary collaboration related scientific fields.
Язык: Английский
Процитировано
22
Cytokine & Growth Factor Reviews, Год журнала: 2024, Номер 79, С. 29 - 38
Опубликована: Авг. 24, 2024
Язык: Английский
Процитировано
10
Cancer Letters, Год журнала: 2024, Номер unknown, С. 217350 - 217350
Опубликована: Ноя. 1, 2024
Pancreatic cancer remains one of the most challenging malignancies to treat due its late-stage diagnosis, aggressive progression, and high resistance existing therapies. This review examines latest advancements in early detection, therapeutic strategies, with a focus on emerging biomarkers, tumor microenvironment (TME) modulation, integration artificial intelligence (AI) data analysis. We highlight promising including microRNAs (miRNAs) circulating DNA (ctDNA), that offer enhanced sensitivity specificity for early-stage diagnosis when combined multi-omics panels. A detailed analysis TME reveals how components such as cancer-associated fibroblasts (CAFs), immune cells, extracellular matrix (ECM) contribute therapy by creating immunosuppressive barriers. also discuss interventions target these components, aiming improve drug delivery overcome evasion. Furthermore, AI-driven analyses are explored their potential interpret complex data, enabling personalized treatment strategies real-time monitoring response. conclude identifying key areas future research, clinical validation regulatory frameworks AI applications, equitable access innovative comprehensive approach underscores need integrated, outcomes pancreatic cancer.
Язык: Английский
Процитировано
6
Coordination Chemistry Reviews, Год журнала: 2024, Номер 518, С. 216056 - 216056
Опубликована: Июль 3, 2024
Язык: Английский
Процитировано
4
Aggregate, Год журнала: 2025, Номер unknown
Опубликована: Фев. 20, 2025
ABSTRACT Tumor metastasis accounts for the major portion of cancer‐related deaths. Magnetic resonance imaging (MRI) is a valuable modality tumor diagnosis in clinical applications, offering detailed soft tissue images with excellent spatial resolution and good biosafety. However, low sensitivity lack specificity to disease sites limit application MRI contrast agents early precise detection small primary metastatic cancers. Therefore, there an urgent need innovative enhanced relaxivity, target ability, pharmacokinetics improve widen window meantime. Here, we reported dual‐targeting protein agent (EPR‐DTPA‐Gd) fused by nanobody against epidermal growth factor receptor 1 (EGFR), integrin α v β 3 ‐binding cyclic nonapeptide, elastin‐like polypeptide. We found that this exhibited high overexpressed EGFR MRI. Furthermore, EPR‐DTPA‐Gd had longitudinal relaxation rate ( r ) (68.76 mM −1 s per molecule) improved behavior imaging. Using T1‐weighted imaging, successfully detected series metastases smallest 0.012 mm 2 (213 µm × 58 µm) liver model human cervical carcinoma HeLa cells, which cannot be clinically approved agent. The heightened intrinsic facilitates lesions, supporting sophisticated image‐guided interventions management high‐risk patient cohorts.
Язык: Английский
Процитировано
0
Micromachines, Год журнала: 2025, Номер 16(3), С. 243 - 243
Опубликована: Фев. 20, 2025
Polymerase chain reaction (PCR) chips are advanced, microfluidic platforms that have revolutionized biomarker discovery and validation because of their high sensitivity, specificity, throughput levels. These miniaturize traditional PCR processes for the speed precision nucleic acid detection relevant to advancing drug development. Biomarkers, which useful in helping explain disease mechanisms, patient stratification, therapeutic monitoring, hard identify validate due complexity biological systems limitations techniques. The challenges respond include high-throughput capabilities coupled with real-time quantitative analysis, enabling researchers novel biomarkers greater accuracy reproducibility. More recent design improvements further expanded functionality also digital multiplex technologies. Digital ideal quantifying rare biomarkers, is essential oncology infectious research. In contrast, enable simultaneous analysis multiple targets, therefore simplifying validation. Furthermore, single-cell made it possible detect at unprecedented resolution, hence revealing heterogeneity within cell populations. transforming development, target identification, efficacy assessment. They play a major role development companion diagnostics and, therefore, pave way personalized medicine, ensuring right receives treatment. While this tremendously promising technology has exhibited many regarding its scalability, integration other omics technologies, conformity regulatory requirements, still prevail. Future breakthroughs chip manufacturing, artificial intelligence, multi-omics applications will expand capabilities. not only be important acceleration but raising bar improving outcomes hence, global health care as these technologies continue mature.
Язык: Английский
Процитировано
0
Diagnostics, Год журнала: 2025, Номер 15(5), С. 628 - 628
Опубликована: Март 5, 2025
Cancer cells exhibit abnormal behavior compared to normal cells. They ignore growth arrest signals such as contact inhibition, a mechanism that stops their proliferation when they collide with surrounding cells, and proliferate in an uncontrolled manner, destroying tissue. Early detection treatment of cancer are therefore important for healthy longevity. differ from characteristic gene expression due abnormalities. markers reflect these characteristics have been searched applied diagnosis. Although analysis blood antigens has the main method, further development diagnostic system is needed early cancer. Next-generation sequencers improved technology, making it possible analyze detailed nucleic acid molecules or urine. In addition, release extracellular vesicles, exosomes, which known contain may serve markers. This review summarizes latest findings on exosomal
Язык: Английский
Процитировано
0
Current Pharmacology Reports, Год журнала: 2025, Номер 11(1)
Опубликована: Апрель 25, 2025
Язык: Английский
Процитировано
0
Journal of Biomaterials Science Polymer Edition, Год журнала: 2025, Номер unknown, С. 1 - 38
Опубликована: Апрель 28, 2025
Polyamidoamine dendrimer (PAMAM) are effective carriers that transport diagnostic imaging reagents and drugs to the tumor site. Their excellent bio-compatibility bio-degradability reduce damage healthy tissues, resulting in improved treatment efficacy. Dendrimer molecules particularly useful targeted drug delivery within malignant cells. This article reviews recent progress of PAMAM treating breast cancer, lung hepatocellular colorectal gastric prostate glioblastoma. review aims provide new feasible ideas for cancer diagnosis while also serving as a significant reference point personalized therapy based on materials.
Язык: Английский
Процитировано
0
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2024, Номер 329, С. 125631 - 125631
Опубликована: Дек. 19, 2024
Язык: Английский
Процитировано
1