Applications of cell penetrating peptide-based drug delivery system in immunotherapy DOI Creative Commons
Jingjing Du, Ruyan Zhang, Shuqi Jiang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Янв. 22, 2025

Cell penetrating peptides (CPPs) are usually positive charged and have good cell membrane permeability. Meanwhile, CPPs facile to synthesize, can be functionalized satisfy different demands, such as cyclization, incorporating unnatural amino acids, lipid conjugation. These properties made them efficient drug-delivery tools deliver therapeutic molecules cells tissues in a nontoxic manner, including small molecules, DNA, siRNA, proteins other various nanoparticles. However, the poor serum stability low tumor targeting ability also hindered their broad application. Besides, inappropriate chemical modification lead disruption nonspecific toxicity. In this paper, we first reviewed recent advances CPP applications for cancer therapy via covalent or non-covalent manners. We carefully analyzed advantages disadvantages of each modifications drug delivery. Then, concluded progress clinical trials diseases. Finally, discussed challenges opportunities met translate into applications. This review presented new insight delivery, which could provide advice on design clinically effective systemic delivery systems using CPPs.

Язык: Английский

Applications of cell penetrating peptide-based drug delivery system in immunotherapy DOI Creative Commons
Jingjing Du, Ruyan Zhang, Shuqi Jiang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Янв. 22, 2025

Cell penetrating peptides (CPPs) are usually positive charged and have good cell membrane permeability. Meanwhile, CPPs facile to synthesize, can be functionalized satisfy different demands, such as cyclization, incorporating unnatural amino acids, lipid conjugation. These properties made them efficient drug-delivery tools deliver therapeutic molecules cells tissues in a nontoxic manner, including small molecules, DNA, siRNA, proteins other various nanoparticles. However, the poor serum stability low tumor targeting ability also hindered their broad application. Besides, inappropriate chemical modification lead disruption nonspecific toxicity. In this paper, we first reviewed recent advances CPP applications for cancer therapy via covalent or non-covalent manners. We carefully analyzed advantages disadvantages of each modifications drug delivery. Then, concluded progress clinical trials diseases. Finally, discussed challenges opportunities met translate into applications. This review presented new insight delivery, which could provide advice on design clinically effective systemic delivery systems using CPPs.

Язык: Английский

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