Demystifying the Potential of Polymeric Lipids as Substitute in Regenerative Applications: A Review
Polymers for Advanced Technologies,
Год журнала:
2025,
Номер
36(2)
Опубликована: Фев. 1, 2025
ABSTRACT
The
objective
of
a
regenerative
medicine
is
to
repair,
restore,
and
regenerate
tissues
organs
that
occurred
due
injury
or
defect
disease.
Additionally,
the
purpose
reverse
aging
process
body
by
utilizing
body's
innate
healing
ability.
There
still
significant
venture
needs
be
directed
for
advancement
in
arena
medicine,
which
makes
use
products
derived
from
cell
therapy
as
well
biomedical.
Stem
cells
growth
factors
are
primary
components
medicine;
hence,
novel
drug
delivering
systems
now
being
studied
augment
transport
active
pharmaceuticals.
Lipid‐based
complexed
with
therapeutics
suited
site‐specific
controlled
release.
Lipids
biocompatible
available
various
sources
molecular
weights
self‐assemble
into
forms
hydrophilic
hydrophobic
parts.
By
enhancing
plasma
membrane
fluidity,
excipients
such
non‐ionic
surfactants,
fatty
acids,
glycerides
increase
permeability.
Liposomes,
nanoparticles,
nano‐emulsions,
micelles
nano‐lipid
carriers
can
improve
bioavailability
both
lipophilic
medicines.
lipoidal‐polymeric
had
emerged
promising
multifaceted
application
cytocompatibility,
ecofriendly,
ability
encapsulate
variety
drugs.
Further,
treatment
biomedical
tissue
engineering,
rapidly
developing
discipline.
Furthermore,
similar
vein,
delivery
technologies
combined
stem
promote
engraftment,
differentiation,
survival.
Hence
colloidal
carrier
has
impending
versatile
applications.
Therefore,
review
offer
an
abridged
information
on
significance
technology
offering
confined
ecosystem
facilitates
them
thrive
distinguish
effective
manner.
Язык: Английский
Unlocking the multifaceted potential of lipid-based dispersion as a drug carrier: Targeted applications and stability improvement strategies
Journal of Dispersion Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 1 - 33
Опубликована: Апрель 28, 2025
Язык: Английский
“Advances in biomarker discovery and diagnostics for alzheimer’s disease”
Neurological Sciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Cerebrospinal fluid LMO4 as a synaptic biomarker linked to Alzheimer’s disease pathology and cognitive decline
Journal of Alzheimer s Disease,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Background
LIM-domain-only
4
(LMO4)
is
involved
in
neurodevelopment
and
synaptic
plasticity,
but
its
role
the
pathogenesis
of
Alzheimer's
disease
(AD)
remains
unclear.
Objective
To
investigate
association
between
cerebrospinal
fluid
(CSF)
LMO4
levels
core
AD
biomarkers,
neurodegeneration,
cognitive
decline.
Methods
We
included
703
participants
from
Disease
Neuroimaging
Initiative
(ADNI).
Associations
CSF
biomarkers
(Aβ
42
,
Ptau181,
amyloid
PET)
postmortem
neuropathology
were
evaluated.
also
explored
cross-sectional
longitudinal
associations
neurodegeneration
function.
Receiver
operating
characteristic
(ROC)
analysis
assessed
diagnostic
accuracy
distinguishing
Aβ-positive
Aβ-negative
PET-confirmed
cases.
Mediation
potential
mediating
Aβ
pathology
tau
pathology.
Results
decreased
with
abnormal
impairment.
Lower
associated
increased
pathology,
brain
atrophy,
decline,
neuropathology.
partially
mediated
relationship
demonstrated
acceptable
discriminative
ability
non-AD
Conclusions
plays
a
crucial
progression
may
represent
therapeutic
target
for
treatment.
Язык: Английский