Advanced Materials Technologies,
Год журнала:
2022,
Номер
7(9)
Опубликована: Март 14, 2022
Abstract
The
traditional
way
of
disease
diagnosis
is
to
detect
biomarkers
in
serum,
blood,
urine,
and
saliva,
but
it
often
faces
wound
infection
pain,
usually
requires
professional
medical
personnel
operate,
which
unacceptable
for
most
people.
As
a
result,
minimally
invasive
detection
has
attracted
wide
attention
expected
become
new
method
patient
monitoring
diagnosis.
Interstitial
fluid
(ISF)
acts
as
medium
between
cells
the
circulatory
system,
serving
reservoir
biomolecules,
nutrients,
metabolic
products.
Microneedles
(MNs)
are
effective
carriers
delivering
drugs,
vaccines,
stem
cells.
What's
more,
MNs
provide
painless,
simple,
collect
skin
ISF.
In
summary,
structural
functional
characteristics
incomparable
advantages
open
door
future
monitoring.
techniques
invasive,
convenient,
compliant
individualized
long‐term
treatments,
up
areas
this
review,
various
ISF
sampling
reviewed,
their
challenges
development
prospects
discussed.
Advanced Healthcare Materials,
Год журнала:
2022,
Номер
11(10)
Опубликована: Янв. 16, 2022
Abstract
Theranostic
system
combined
diagnostic
and
therapeutic
modalities
is
critical
for
the
real‐time
monitoring
of
disease‐related
biomarkers
personalized
therapy.
Microneedles,
as
a
multifunctional
platform,
are
promising
transdermal
diagnostics
drug
delivery.
They
have
shown
attractive
properties
including
painless
skin
penetration,
easy
self‐administration,
prominent
effects,
good
biosafety.
Herein,
an
overview
microneedles‐based
diagnosis,
therapies,
theranostic
systems
given.
Four
detection
methods
concluded
based
on
sensing
mechanism:
i)
electrochemistry,
ii)
fluorometric,
iii)
colorimetric,
iv)
Raman
methods.
Additionally,
robust
microneedles
suitable
implantable
Microneedles‐assisted
delivery
can
be
primarily
classified
passive,
active,
responsive
release,
release
mechanisms.
oral
mechanisms
also
presented
in
this
review.
Furthermore,
key
frontier
developments
microneedles‐mediated
major
selling
points
emphasized
These
into
open‐loop
closed‐loop
indirectness
directness
feedback
between
diagnosis
therapy,
respectively.
Finally,
conclusions
future
perspectives
next‐generation
discussed.
Taken
together,
microneedle‐based
new
avenue
disease‐specific
applications.
Lab on a Chip,
Год журнала:
2023,
Номер
23(5), С. 869 - 887
Опубликована: Янв. 1, 2023
This
review
summarizes
state-of-the-art
microneedle-based
detection
and
sensing
systems,
highlighting
the
objective
significance,
principles,
systematic
construction,
validation
models
of
these
microneedles.
The
rapid
development
of
wearable
biosensing
calls
for
next-generation
devices
that
allow
continuous,
real-time,
and
painless
monitoring
health
status
along
with
responsive
medical
treatment.
Microneedles
have
exhibited
great
potential
the
direct
access
dermal
interstitial
fluid
(ISF)
in
a
minimally
invasive
manner.
Recent
studies
microneedle-based
evolved
from
conventional
off-line
detection
to
multiplexed,
wireless,
integrated
sensing.
In
this
review,
classification
fabrication
techniques
microneedles
are
first
introduced,
then
representative
examples
transdermal
different
sensing
modalities
summarized.
State-of-the-art
advances
therapeutic
closed-loop
systems
presented
formulate
guidelines
healthcare
platforms.
challenges
prospects
discussed
pave
new
avenue
toward
pragmatic
applications
real
world.
Abstract
Point‐of‐care
(POC)
has
the
capacity
to
support
low‐cost,
accurate
and
real‐time
actionable
diagnostic
data.
Microneedle
sensors
have
received
considerable
attention
as
an
emerging
technique
evolve
blood‐based
diagnostics
owing
their
direct
painless
access
a
rich
source
of
biomarkers
from
interstitial
fluid.
This
review
systematically
summarizes
recent
innovations
in
microneedle
with
particular
focus
on
utility
POC
personalized
medicine.
The
integration
various
sensing
techniques,
mostly
electrochemical
optical
sensing,
been
established
diverse
architectures
“lab‐on‐a‐microneedle”
platforms.
tailored
geometries,
mechanical
flexibility,
biocompatibility
are
constructed
variety
materials
fabrication
methods.
Microneedles
categorized
into
four
types:
metals,
inorganics,
polymers,
hydrogels,
elaborated
state‐of‐the‐art
bioengineering
strategies
for
minimally
invasive,
continuous,
multiplexed
sensing.
employed
detect
wide
range
electrolytes,
metabolites,
polysaccharides,
nucleic
acids,
proteins
drugs.
Insightful
perspectives
outlined
biofluid,
microneedles,
biosensors,
devices,
theragnostic
instruments,
which
depict
bright
future
upcoming
intelligent
health
management.
Communications Materials,
Год журнала:
2024,
Номер
5(1)
Опубликована: Март 13, 2024
Abstract
Interstitial
fluid
(ISF),
a
biological
rich
in
diverse
biomarkers
and
analytes
similar
to
blood
composition,
has
garnered
significant
attention
as
valuable
source
of
clinically
relevant
information.
Consequently,
ISF-based
wearable
biosensors
are
emerging
powerful
tools
for
non-invasive
minimally
invasive
disease
diagnosis,
personalized
medicine,
other
healthcare
biomedical
applications.
This
review
provides
comprehensive
overview
recent
advancements
biosensors,
with
particular
focus
on
ISF
sensors.
We
first
offer
insights
into
sampling
techniques
discuss
sensing
strategies
that
encompass
materials,
fabrication
methods,
mechanisms.
Then,
we
present
their
Finally,
address
the
challenges
faced
this
field
forward-looking
perspective
promising
future
directions.
ACS Sensors,
Год журнала:
2024,
Номер
9(3), С. 1149 - 1161
Опубликована: Март 13, 2024
Interstitial
fluid
(ISF)
has
attracted
extensive
attention
in
an
extremely
wide
range
of
areas
due
to
its
unique
advantages,
such
as
portability,
high
precision,
comfortable
operation,
and
superior
stability.
In
recent
years,
the
microneedle
(MN)
technique
been
considered
be
excellent
tool
for
extracting
ISF
because
it
is
painless
noninvasive.
Recent
reports
have
shown
that
MN
good
application
prospects
extraction.
this
review,
we
provide
comprehensive
in-depth
insight
into
integrated
devices
detection,
covering
basic
structure
well
fabrication
various
applications
Challenges
are
highlighted,
with
a
discussion
on
how
transition
MN-integrated
toward
personalized
healthcare
monitoring
systems.
Biosensors,
Год журнала:
2021,
Номер
11(9), С. 296 - 296
Опубликована: Авг. 25, 2021
Chronic
diseases
(CDs)
are
noncommunicable
illnesses
with
long-term
symptoms
accounting
for
~70%
of
all
deaths
worldwide.
For
the
diagnosis
and
prognosis
CDs,
accurate
biomarker
detection
is
essential.
Currently,
CD-associated
biomarkers
employed
through
complex
platforms
certain
limitations
in
their
applicability
performance.
There
hence
unmet
need
to
present
innovative
strategies
that
applicable
point-of-care
(PoC)
settings,
also,
provide
precise
biomarkers.
On
other
hand,
especially
at
PoC
microneedle
(MN)
technology,
which
comprises
micron-size
needles
arranged
on
a
miniature
patch,
has
risen
as
revolutionary
approach
biosensing
strategies,
opening
novel
horizons
improve
existing
devices.
Various
MN-based
have
been
manufactured
distinctive
purposes
employing
several
techniques
materials.
The
development
biosensors
real-time
monitoring
garnered
huge
attention
recent
years.
Herein,
we
summarize
basic
concepts
MNs,
including
microfabrication
techniques,
design
parameters,
mechanism
action
platform
CD
diagnosis.
Moreover,
advances
use
MNs
introduced
finally
relevant
clinical
trials
carried
out
using
devices
highlighted.
This
review
aims
address
potential
