Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Intelligent
wearable
sensors,
empowered
by
machine
learning
and
innovative
smart
materials,
enable
rapid,
accurate
disease
diagnosis,
personalized
therapy,
continuous
health
monitoring
without
disrupting
daily
life.
This
integration
facilitates
a
shift
from
traditional,
hospital-centered
healthcare
to
more
decentralized,
patient-centric
model,
where
sensors
can
collect
real-time
physiological
data,
provide
deep
analysis
of
these
data
streams,
generate
actionable
insights
for
point-of-care
precise
diagnostics
therapy.
Despite
rapid
advancements
in
learning,
sensing
technologies,
there
is
lack
comprehensive
reviews
that
systematically
examine
the
intersection
fields.
review
addresses
this
gap,
providing
critical
technologies
advanced
materials
artificial
Intelligence.
The
state-of-the-art
materials-including
self-healing,
metamaterials,
responsive
materials-that
enhance
sensor
functionality
are
first
examined.
Advanced
methodologies
integrated
into
devices
discussed,
their
role
biomedical
applications
highlighted.
combined
impact
intelligent
therapeutics
also
Finally,
existing
challenges,
including
technical
compliance
issues,
information
security
concerns,
regulatory
considerations
addressed,
future
directions
advancing
proposed.
ACS Applied Materials & Interfaces,
Год журнала:
2022,
Номер
14(17), С. 19204 - 19211
Опубликована: Апрель 21, 2022
Efficient
and
timely
testing
has
taken
center
stage
in
the
management,
control,
monitoring
of
current
COVID-19
pandemic.
Simple,
rapid,
cost-effective
diagnostics
are
needed
that
can
complement
polymerase
chain
reaction-based
methods
lateral
flow
immunoassays.
Here,
we
report
development
an
electrochemical
sensing
platform
based
on
single-walled
carbon
nanotube
screen-printed
electrodes
(SWCNT-SPEs)
functionalized
with
a
redox-tagged
DNA
aptamer
specifically
binds
to
receptor
binding
domain
SARS-CoV-2
spike
protein
S1
subunit.
Single-step,
reagentless
detection
is
achieved
through
binding-induced,
concentration-dependent
folding
reduces
efficiency
electron
transfer
process
between
redox
tag
electrode
surface
causes
suppression
resulting
amperometric
signal.
This
aptasensor
specific
for
target
dissociation
constant
(KD)
value
43
±
4
nM
limit
7
nM.
We
demonstrate
be
detected
both
buffer
solution
artificial
viral
transport
medium
widely
used
collection
nasopharyngeal
swabs,
no
cross-reactivity
observed
presence
different,
non-target
proteins.
expect
this
SWCNT-SPE-based
format
will
prove
useful
other
targets
which
nucleic
acid
ligands
made
available.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(50)
Опубликована: Сен. 30, 2022
Nucleic
acids
are
remarkable
molecules.
In
addition
to
Watson-Crick
base
pairing,
the
different
structural
motifs
of
these
molecules
can
bind
non-nucleic
acid
targets
or
catalyze
chemical
reactions.
Additionally,
nucleic
easily
modified
with
functional
groups.
These
properties
make
acids,
particularly
DNA,
ideally
suited
for
use
in
electrochemical
biosensors,
both
as
biorecognition
elements
and
redox
reporter
probes.
this
Minireview,
we
will
review
historical
evolution
probes
biosensors.
We
then
specific
examples
nucleic-acid-based
biosensors
that
have
been
evaluated
clinical
areas
infectious
disease,
cancer,
cardiovascular
health.
ACS Omega,
Год журнала:
2022,
Номер
7(15), С. 12467 - 12473
Опубликована: Апрель 5, 2022
Rapid
diagnosis
is
a
critical
aspect
associated
with
controlling
the
spread
of
COVID-19.
Electrochemical
sensor
platforms
are
ideally
suited
for
rapid
and
highly
sensitive
detection
biomolecules.
This
review
focuses
on
state-of-the-art
COVID-19
biomarker
by
utilizing
electrochemical
biosensing
platforms.
Point-of-care
(POC)
sensing
one
most
promising
emerging
fields
in
detecting
quantifying
health
biomarkers.
biosensors
play
major
role
development
point-of-care
devices
because
their
high
sensitivity,
specificity,
ability
analysis.
Integration
electrochemistry
technologies
context
screening
has
facilitated
convenient
operation,
miniaturization,
portability.
Identification
potential
biomarkers
disease
crucial
patient
monitoring
concerning
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2).
In
this
review,
we
will
discuss
choice
addition
to
various
types
sensors
that
have
been
developed
meet
needs
severity
The
SARS-CoV-2
virus
and
COVID-19
pandemic
continue
to
demand
effective
diagnostic
therapeutic
solutions.
Finding
these
solutions
requires
highly
functional
molecular
recognition
elements.
Nucleic
acid
aptamers
represent
a
possible
solution.
Characterized
by
their
high
affinity
specificity,
can
be
rapidly
identified
from
random-sequence
nucleic
libraries.
Over
the
past
two
years,
many
labs
around
world
have
rushed
create
diverse
that
target
important
structural
proteins
of
SARS-CoV-2:
spike
(S)
protein
nucleocapsid
(N)
protein.
These
led
identification
show
real
promise
for
development
tests
agents
SARS-CoV-2.
Herein
we
review
all
developments,
with
special
focus
on
aptasensors
detecting
include
electrochemical
optical
sensors,
lateral
flow
devices,
aptamer-linked
immobilized
sorbent
assays.
Chemosensors,
Год журнала:
2022,
Номер
10(7), С. 269 - 269
Опубликована: Июль 11, 2022
Fast
and
accurate
point-of-care
testing
(POCT)
of
infectious
diseases
is
crucial
for
diminishing
the
pandemic
miseries.
To
fight
coronavirus
disease
2019
(COVID-19),
numerous
interesting
electrochemical
(POC)
tests
have
been
evolved
to
rapidly
identify
causal
organism
SARS-CoV-2
virus,
its
nucleic
acid
antigens,
antibodies
patients.
Many
those
biosensors
are
impressive
in
terms
miniaturization,
mass
production,
ease
use,
speed
test,
they
could
be
recommended
future
applications
pandemic-like
circumstances.
On
other
hand,
self-diagnosis,
sensitivity,
specificity,
surface
chemistry,
components,
device
configuration,
portability,
small
analyzers,
features
can
yet
improved.
Therefore,
this
report
reviews
developmental
trend
POC
(i.e.,
test
platforms
features)
reported
rapid
diagnosis
COVID-19
correlates
any
significant
advancements
with
relevant
references.
POCTs
incorporating
microfluidic/plastic
chips,
paper
devices,
nanomaterial-aided
platforms,
smartphone
integration,
epidemiological
reporting
attributes
also
surfed
help
preparedness.
This
review
especially
screens
low-cost
easily
affordable
setups
so
that
management
becomes
faster
easier.
Overall,
a
wide-ranging
package
finding
appropriate
strategies
POCT
targeting
detection.
Bioengineering & Translational Medicine,
Год журнала:
2023,
Номер
8(3)
Опубликована: Янв. 3, 2023
Abstract
Microbial
pathogens
have
threatened
the
world
due
to
their
pathogenicity
and
ability
spread
in
communities.
The
conventional
laboratory‐based
diagnostics
of
microbes
such
as
bacteria
viruses
need
bulky
expensive
experimental
instruments
skilled
personnel
which
limits
usage
resource‐limited
settings.
biosensors‐based
point‐of‐care
(POC)
shown
huge
potential
detect
microbial
a
faster,
cost‐effective,
user‐friendly
manner.
use
various
transducers
electrochemical
optical
along
with
microfluidic
integrated
biosensors
further
enhances
sensitivity
selectivity
detection.
Additionally,
microfluidic‐based
offer
advantages
multiplexed
detection
analyte
deal
nanoliters
volume
fluid
an
portable
platform.
In
present
review,
we
discussed
design
fabrication
POCT
devices
for
include
bacteria,
viruses,
fungi,
parasites.
techniques
current
advances
this
field
terms
platforms
that
mainly
microfluidic‐
based
approaches
smartphone
Internet‐of‐things
(IoT)
Internet‐of‐Medical‐Things
(IoMT)
systems
been
highlighted.
Further,
availability
commercial
will
be
briefed.
end,
challenges
while
POC
expected
future
biosensing
discussed.
biosensor‐based
IoT/IoMT
usually
collect
data
track
community
infectious
diseases
would
beneficial
better
preparedness
futuristic
pandemics
is
prevent
social
economic
losses.
