Power and Sensitivity Management of Carbon Nanotube Transistor Glucose Biosensors DOI

Jianping He,

Xianmao Cao,

Haiyang Liu

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 16(1), С. 1351 - 1360

Опубликована: Дек. 27, 2023

Continuous glucose monitoring (CGM), which is significant for the daily management of diabetes, requires a low-power-consumption sensor system that can track low nanomolar levels in physiological fluids, such as sweat and tears. However, traditional electrochemical methods are limited to analytes micromolar millimolar ranges entail high power consumption. Carbon nanotube (CNT) film field-effect transistors (FETs) promising constructing extremely sensitive biosensors, but their wide applications CGM by strong screening effect fluids zero charge molecules. In this study, we demonstrate aptamer-modified CNT FET biosensor realize highly with sub-nW consumption applying suitable gate voltage. A positive voltage enlarge effective Debye length at double layer reduce local ion population nearby then improve sensitivity FET-based biosensors 5 times. We construct sensors limit detection 0.5 fM, record dynamic range up 10

Язык: Английский

Aptamer‐functionalized field‐effect transistor biosensors for disease diagnosis and environmental monitoring DOI Creative Commons
Jingfeng Wang, Duo Chen,

Wanting Huang

и другие.

Exploration, Год журнала: 2023, Номер 3(3)

Опубликована: Май 11, 2023

Nano-biosensors that are composed of recognition molecules and nanomaterials have been extensively utilized in disease diagnosis, health management, environmental monitoring. As a type nano-biosensors, molecular specificity field-effect transistor (FET) biosensors with signal amplification capability exhibit prominent advantages including fast response speed, ease miniaturization, integration, promising their high sensitivity for detection identification. With intrinsic characteristics stability structural tunability, aptamer has become one the most commonly applied biological units FET sensing fields. This review summarizes recent progress based on functionalized medical diagnosis The structure, principles, preparation methods, functionalization strategies modified were comprehensively summarized. relationship between structure performance was reviewed. Furthermore, challenges future perspectives also discussed, so as to provide support development efficient healthcare management monitoring devices.

Язык: Английский

Процитировано

37
Amplification‐Free Detection of SARS‐CoV‐2 Down to Single Virus Level by Portable Carbon Nanotube Biosensors DOI
Yuqi Liang, Mengmeng Xiao, Jing Xie

и другие.

Small, Год журнала: 2023, Номер 19(34)

Опубликована: Апрель 12, 2023

The rapid and sensitive detection of trace-level viruses in a simple reliable way is great importance for epidemic prevention control. Here, multi-functionalized floating gate carbon nanotube field effect transistor (FG-CNT FET) based biosensor reported the single virus level SARS-CoV-2 antigen RNA rapidly with portable sensing platform. aptamers functionalized sensors can detect antigens from unprocessed nasopharyngeal swab samples within 1 min. Meanwhile, enhanced by multi-probe strategy, FG-CNT FET-based long chain directly without amplification down to device, constructed packaged sensor chips terminal, distinguish 10 COVID-19 patients healthy individuals clinical tests both RNAs combination strategy an combined overall percent agreement (OPA) close 100%. results provide general method enhance sensitivity biochemical nucleic acid molecules demonstrate that CNT FG FET versatile integrated platform ultrasensitive multibiomarker has potential point-of-care (POC) tests.

Язык: Английский

Процитировано

32
Interface‐Engineered Field‐Effect Transistor Electronic Devices for Biosensing DOI
Yun Zhang, Duo Chen, He Wang

и другие.

Advanced Materials, Год журнала: 2023, Номер unknown

Опубликована: Дек. 4, 2023

Promising advances in molecular medicine have promoted the urgent requirement for reliable and sensitive diagnostic tools. Electronic biosensing devices based on field-effect transistors (FETs) exhibit a wide range of benefits, including rapid label-free detection, high sensitivity, easy operation, capability integration, possessing significant potential application disease screening health monitoring. In this perspective, tremendous efforts achievements development high-performance FET biosensors past decade are summarized, with emphasis interface engineering FET-based electrical platforms biomolecule identification. First, an overview strategies modulation recognition element design is discussed detail. For further step, applications vitro detection real-time monitoring biological systems comprehensively reviewed. Finally, key opportunities challenges electronic discussed. It anticipated that comprehensive understanding will inspire additional techniques developing highly sensitive, specific, stable as well emerging designs next-generation electronics.

Язык: Английский

Процитировано

25
Low-dimensionality carbon-based biosensors: the new era of emerging technologies in bioanalytical chemistry DOI Open Access
Karla R. Castro, Rafael N. P. Colombo, Rodrigo M. Iost

и другие.

Analytical and Bioanalytical Chemistry, Год журнала: 2023, Номер 415(18), С. 3879 - 3895

Опубликована: Фев. 9, 2023

Язык: Английский

Процитировано

24
Ultra-sensitive and rapid detection of Salmonella enterica and Staphylococcus aureus to single-cell level by aptamer-functionalized carbon nanotube field-effect transistor biosensors DOI

Xiaoxuan Feng,

Pengzhen Li,

Tingxian Li

и другие.

Biosensors and Bioelectronics, Год журнала: 2024, Номер 257, С. 116333 - 116333

Опубликована: Апрель 24, 2024

Язык: Английский

Процитировано

14
Recent Progress in Flexible Microelectrode Arrays for Combined Electrophysiological and Electrochemical Sensing DOI Creative Commons

Umisha Siwakoti,

Steven A. Jones, Deepak Kumbhare

и другие.

Biosensors, Год журнала: 2025, Номер 15(2), С. 100 - 100

Опубликована: Фев. 10, 2025

Understanding brain function requires advanced neural probes to monitor electrical and chemical signaling across multiple timescales regions. Microelectrode arrays (MEAs) are widely used record neurophysiological activity various depths regions, providing single-unit resolution for extended periods. Recent advancements in flexible MEAs, built on micrometer-thick polymer substrates, have improved integration with tissue by mimicking the brain's soft nature, reducing mechanical trauma inflammation. These flexible, subcellular-scale MEAs can stable signals months, making them ideal long-term studies. In addition recording, been functionalized electrochemical neurotransmitter detection. Electroactive neurotransmitters, such as dopamine, serotonin, adenosine, be directly measured via methods, particularly carbon-based surfaces. For non-electroactive neurotransmitters like acetylcholine, glutamate, γ-aminobutyric acid, alternative strategies, enzyme immobilization aptamer-based recognition, employed generate signals. This review highlights recent developments MEA fabrication functionalization achieve both electrophysiological recordings, minimizing sensor fowling damage when implanted long-term. It covers multi-time scale detection, development of conducting nanomaterial composite coatings enhance sensitivity, incorporation recognition carbon electrodes MEAs. Finally, it summarizes strategies acquire measurements from same device.

Язык: Английский

Процитировано

1
Robust Carbon Nanotube Transistor Ion Sensors with Near-Nernstian Sensitivity for Multi-Ion Detection in Neurological Diseases DOI Creative Commons

Lidan Yan,

Yang Zhang,

Zhibiao Zhu

и другие.

Nanomaterials, Год журнала: 2025, Номер 15(6), С. 447 - 447

Опубликована: Март 15, 2025

Accurate monitoring of sodium and potassium ions in biological fluids is crucial for diseases related to electrolyte imbalance. Low-dimensional materials such as carbon nanotubes can be used construct biochemical sensors based on high-performance field effect transistor (FET), but they face the problems poor device consistency difficulty stable reliable operation. In this work, we mass-produced nanotube (CNT) floating-gate field-effect devices with high uniformity through micro-/nanofabrication technology improve accuracy reliability detection without need statistical analysis machine learning. By introducing waterproof hafnium oxide gate dielectrics CNT FET channel, not only effectively protect channel area also significantly stability sensor. We have prepared array sensing that detect potassium, sodium, calcium, hydrogen artificial cerebrospinal fluid. The concentration range 10 μM–100 mM pH 3–pH 9, a sensitivity close Nernst limit, exhibits selective long-term responses. This could help achieve early diagnosis real-time central nervous system diseases, highlighting potential ion-sensing platform highly sensitive various neurobiological markers.

Язык: Английский

Процитировано

1
Carbon nanotube field-effect transistor based pH sensors DOI
Kemin Wang, Xiaofeng Liu,

Zijun Zhao

и другие.

Carbon, Год журнала: 2023, Номер 205, С. 540 - 545

Опубликована: Янв. 28, 2023

Язык: Английский

Процитировано

22
Emerging nanotechnology for Alzheimer's disease: From detection to treatment DOI
Nan Song, Si Sun, Ke Chen

и другие.

Journal of Controlled Release, Год журнала: 2023, Номер 360, С. 392 - 417

Опубликована: Июль 10, 2023

Язык: Английский

Процитировано

21
Nanosensor-Driven Detection of Neuron-Derived Exosomal Aβ42 with Graphene Electrolyte-Gated Transistor for Alzheimer’s Disease Diagnosis DOI
Jiahao Li, Wei Ni,

Dan Jin

и другие.

Analytical Chemistry, Год журнала: 2023, Номер 95(13), С. 5719 - 5728

Опубликована: Март 21, 2023

Blood-based tests have sparked tremendous attention in non-invasive early diagnosis of Alzheimer's disease (AD), a most prevalent neurodegenerative malady worldwide. Despite significant progress the methodologies for detecting AD core biomarkers such as Aβ42 from serum/plasma, there remains cautious optimism going forward due to its controversial diagnostic value and relevance. Here, graphene electrolyte-gated transistor biosensor is reported detection serum neuron-derived exosomal (NDE-Aβ42), which an emerging, compelling trove blood biomarker AD. Assisted by antifouling strategy with dual-blocking process, noise against complex biological background was considerably reduced, forging impressive sensitivity gain limit 447 ag/mL. An accurate SH-SY5Y-derived also achieved highly conformable enzyme-linked immunosorbent assay results. Importantly, clinical analysis 27 subjects revealed immense NDE-Aβ42, can outclass that Aβ42. The developed electronic demonstrates, first time, nanosensor-driven NDE-Aβ42 detection, enables reliable discrimination patients non-AD individuals even differential between vascular dementia patients, accuracy 100% Youden index 1. This defines robust approach blood-based confident ascertain.

Язык: Английский

Процитировано

20