Abstract
Wound
healing
is
a
dynamic
and
overlapping
bio‐process
with
varied
cellular
molecular
characteristics
involved.
Traditional
wound
dressings
have
made
significant
achievements
in
accelerating
healing;
however,
they
lack
the
ability
to
monitor
changes
of
wounds,
which
limits
effectiveness
management.
Currently,
development
flexible
electronics‐based
intelligent
that
can
real‐time
manner
make
positive
impact
on
clinical
practice.
MXenes,
also
known
as
type
2D
inorganic
compound,
are
generally
considered
ideal
precursors
for
fabricating
electronics.
MXenes‐based
electronics
not
only
biomarkers
wounds
(e.g.,
temperature,
pH,
lactic
acid)
but
promote
by
combining
other
bio‐activities.
This
review
begins
brief
introduction
challenges
associated
early
diagnosis
wounds.
It
then
provides
comprehensive
summary
discussion
fabrication
applications
monitoring
treatment.
Finally,
it
explores
current
future
directions
this
cutting‐edge
field.
Nano-Micro Letters,
Год журнала:
2024,
Номер
17(1)
Опубликована: Ноя. 26, 2024
Abstract
Wearable
sensing
systems
have
been
designed
to
monitor
health
conditions
in
real-time
by
detecting
analytes
human
biofluids.
Wound
diagnosis
remains
challenging,
necessitating
suitable
materials
for
high-performance
wearable
sensors
offer
prompt
feedback.
Existing
devices
limitations
measuring
pH
and
the
concentration
of
pH-dependent
electroactive
species
simultaneously,
which
is
crucial
obtaining
a
comprehensive
understanding
wound
status
optimizing
biosensors.
Therefore,
improving
analysis
system
accuracy
essential.
This
article
introduces
first
example
flexible
array
capable
pyocyanin,
bacterial
virulence
factor,
while
correcting
dynamic
fluctuations.
We
demonstrate
that
this
combined
sensor
enhances
mitigating
impact
variability
on
pyocyanin
response.
Customized
screen-printable
inks
were
developed
enhance
analytical
performance.
The
performances
two
sensitive
(i.e.,
fully-printed
porous
graphene/multiwalled
carbon
nanotube
(CNT)
polyaniline/CNT
composites
sensors)
are
evaluated.
Partial
least
square
regression
employed
analyze
nonzero-order
data
arrays
from
wave
voltammetric
potentiometric
measurements
establish
predictive
model
complex
fluids.
effective
strategy
shows
potential
personalized
applications
due
its
affordability,
ease
use,
ability
adjust
changes.
Engineered Regeneration,
Год журнала:
2024,
Номер
5(2), С. 186 - 198
Опубликована: Март 18, 2024
Persistent
inflammatory
responses
often
occur
when
bacteria
and
other
microorganisms
frequently
invade
colonize
open
wounds
eventually
result
in
the
formation
of
chronic
wounds.
Therefore,
achieving
real-time
detection
invasive
accurately
promptly
is
essential
for
efficient
wound
management
accelerating
healing
process.
Recently,
flexible
wearable
sensors
have
garnered
significant
attention,
especially
those
designed
monitoring
biophysical
or
biochemical
signals
sites
a
minimally
manner.
They
provide
more
precise
continuous
data,
making
them
as
emerging
tools
clinical
diagnostics.
In
this
review,
we
first
discuss
species
community
distribution
different
types
Next,
introduce
currently
developed
techniques
detecting
at
sites.
Following
that,
recent
progress
unresolved
issues
various
We
believe
that
review
can
meaningful
guidance
development
detection.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(11), С. 7101 - 7132
Опубликована: Окт. 28, 2024
Chronic
wounds
are
a
major
healthcare
burden
and
may
severely
affect
the
social,
mental,
economic
status
of
patients.
Any
impairment
in
wound
healing
stages
due
to
underlying
factors
leads
prolonged
time
subsequently
chronic
wounds.
Traditional
approaches
for
treatment
include
dressing
free
local
therapy,
tissue
engineering
based
scaffold
therapies.
However,
traditional
therapies
need
improvisation
have
been
advanced
through
breakthrough
technologies.
The
present
review
spans
further
gives
an
extensive
account
advancements
Cutting
edge
technologies,
such
as
3D
printing,
which
includes
inkjet
fused
deposition
modeling,
digital
light
processing,
extrusion-based
microneedle
array-based
therapies,
gene
microRNAs
(miRNAs)
smart
dressings
real
monitoring
conditions
assessment
pH,
temperature,
oxygen,
moisture,
metabolites,
their
use
planning
better
strategies
discussed
detail.
future
direction
treatments
that
will
aid
lowering
caused
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(4)
Опубликована: Ноя. 22, 2023
Abstract
Chronic
wounds
are
regarded
as
a
silent
epidemic,
affecting
1–2%
of
the
population
and
representing
2–4%
healthcare
expenses.
The
current
methods
used
to
assess
wound
healing
process
based
on
visual
evaluation
physical
parameters.
This
work
aims
design
wearable
non‐invasive
device
capable
evaluating
three
parameters
simultaneously:
pH
levels
glucose
matrix
metalloproteinase
(MMP)
present
in
exudate.
is
composed
independent
polymer
optical
fibers
functionalized
with
fluorescent‐based
sensing
chemistries
specific
targeted
analytes.
Each
fiber
characterized
terms
detection
sensitivity
selectivity
confirming
their
suitability
for
monitoring
ranges
relevant
environment.
robustness
multi‐sensing
confirmed
analyses
using
complex
solutions
different
(5,
6,
7),
concentrations
(1.25,
2.5,
5
m
),
MMP
µg
mL
−1
).
Given
simple
set‐up,
affordability
materials
possibility
detecting
additional
healing,
such
fiber‐based
devices
could
pave
way
novel
tools
enabling
assessment
from
molecular
perspective.
Biosensors,
Год журнала:
2024,
Номер
14(7), С. 330 - 330
Опубликована: Июль 4, 2024
The
continued
advancement
of
organic
electronic
technology
will
establish
electrochemical
transistors
as
pivotal
instruments
in
the
field
biological
detection.
Here,
we
present
a
comprehensive
review
state-of-the-art
and
advancements
use
biosensors.
This
provides
an
in-depth
analysis
diverse
modification
materials,
methods,
mechanisms
utilized
transistor-structured
biosensors
(OETBs)
for
selective
detection
wide
range
target
analyte
encompassing
electroactive
species,
electro-inactive
cancer
cells.
Recent
advances
OETBs
sensing
systems
wearable
implantable
applications
are
also
briefly
introduced.
Finally,
challenges
opportunities
discussed.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
In
this
work,
we
proposed
a
mechanism
for
hydrogel-based
dressings
to
respond
endogenous
electric
fields
through
exudate
absorption
and
conducted
verification
study
using
polyacrylamide
sodium
alginate
(PAM–SA)
hydrogels.
Advanced Materials Technologies,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 2, 2025
Abstract
Wireless
and
battery‐free
sensor
operation
is
essential
for
sustainable
networks
environmental
health
monitoring.
Achieving
such
a
fully
passive
design
in
electrochemical
sensors
challenging
due
to
the
need
amplification
control
electronics
as
realized
potentiostats.
To
address
this
issue,
organic
transistors
(OECTs)
are
introduced
amplified
demonstrate
an
OECT‐based
oxygen
that
exploits
reduction
of
oxygen,
akin
Clark
electrode.
build
sensor,
transistor
thin
film
fabrication
protocol
integrated
with
deposition
gas
permeable
silicone
membrane
hydrogel
electrolyte.
assess
sensor's
power
consumption,
model
links
consumption
OECT
geometry
material
properties
semiconducting
channel
established.
This
identifies
optimized
compatible
commercial
near‐field
communication
(NFC)
microcontrollers.
In
design,
interrogating
NFC
radio
signal
sufficient
microcontroller,
achieve
readout,
transmit
digitized
current,
enabling
monitoring
air
or
water
without
wired
connections
batteries.
These
findings
provide
first
example
quantitative
argumentation
on
exploiting
OECTs
low‐power
architectures.
Slowly
healing
wounds
significantly
affect
the
life
quality
of
patients
in
different
ways,
due
to
constant
pain,
unpleasant
odor,
reduced
mobility
up
social
isolation,
and
personal
frustration.
While
remote
wound
management
has
become
more
widely
accepted
since
COVID-19
pandemic,
delayed
treatment
remains
frequent
results
several
related
complications.
As
inappropriate
notably
diabetic
foot
ulcers
is
linked
a
high
risk
amputation,
effective
patient-centered
manner
important
be
implemented.
The
integration
diagnostic
devices
into
bandages
under
way,
owing
advancements
materials
science
nanofabrication
strategies
as
well
innovation
communication
technologies
together
with
machine
learning
data-driven
assessment
tools.
Leveraging
advanced
analytical
approaches
around
local
pH,
temperature,
pressure,
biomarker
sensing
expected
facilitate
adequate
treatment.
state-of-the-art
time-resolved
monitoring
status
by
quantifying
key
physiological
parameters
biomarkers'
concentration
presented
herewith.
A
special
focus
will
given
smart
on-demand
delivery
capabilities
for
improved
management.