Korean Journal of Chemical Engineering, Год журнала: 2024, Номер unknown
Опубликована: Окт. 5, 2024
Язык: Английский
Chemosensors, Год журнала: 2025, Номер 13(2), С. 68 - 68
Опубликована: Фев. 15, 2025
Microneedles (MNs) are miniature medical devices, presented as an array of micro-scale needles, each under 1 mm in height with sharp tips. MN technology is becoming a diagnostic platform associated several qualities: no pain and risk infection, offering accuracy, comfort, usability. Monitoring biomarkers interstitial fluid (ISF) real time crucial for tracking changes metabolism assisting the early diagnosis chronic illnesses. Some examples sensors summarized here: real-time sensing two metabolites (lactate glucose or alcohol glucose), transdermal tracing pH, Na+, K+, Ca2+, Li+, Cl−, methotrexate (MTX) monitoring, tyrosinase enzyme melanoma biomarker, integration CRISPR nucleic acid analysis, monitoring plant sap pH leaves plants. The challenges to be addressed realize transition widespread One Health solutions analyzed.
Язык: Английский
Процитировано
1
ACS Sensors, Год журнала: 2024, Номер 9(5), С. 2294 - 2309
Опубликована: Апрель 24, 2024
Bioanalyte collection by blood draw is a painful process, prone to needle phobia and injuries. Microneedles can be engineered penetrate the epidermal skin barrier collect analytes from interstitial fluid, arising as safe, painless, effective alternative hypodermic needles. Although there are plenty of reviews on various types microneedles their use drug delivery systems, lack systematization application polymeric for diagnosis. In this review, we focus current state art field, while providing information safety, preclinical clinical trials, market distribution, outline what believe will future health monitoring.
Язык: Английский
Процитировано
5
Polymers for Advanced Technologies, Год журнала: 2024, Номер 35(12)
Опубликована: Дек. 1, 2024
ABSTRACT This review aims to provide a comprehensive analysis of recent advancements in smart microneedles (MNs) within the biomedical field, focusing on integration stimuli‐responsive polymers for enhanced therapeutic and diagnostic applications. Conventional drug delivery methods are known face limitations precision, safety, patient compliance, which can be addressed by innovative features MNs. Through use various polymers, these MNs have been designed react environmental or physiological cues, allowing on‐demand release, biomarker sensing, localized interventions. Fundamental materials used fabrication MNs, including metals, composite hydrogels, reviewed, different categories stimuli‐responsiveness, such as photo, electro, thermal, mechanical, biochemical, explored. Application‐specific designs areas delivery, cancer therapy, diabetes management, skin disease treatments also examined. this discussion, it is highlighted that poised play significant role advancing personalized noninvasive medical treatments.
Язык: Английский
Процитировано
4
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 10, 2025
Abstract The skin microenvironment is a highly intricate and dynamic system, characterized by an acidic pH, diverse microbiota, various metabolites, numerous enzymes, creating both challenges opportunities for the development of innovative drug delivery systems. Dissolving Microneedles (MNs) have emerged as promising, pain‐free alternative to conventional invasive injections, offering ability deliver therapeutics through gradual degradation within skin's interstitial fluids. Building upon unique properties dissolving MNs, novel concept introduced wherein MNs serve in situ chemical reaction chambers. In this framework, can reactants or catalysts skin, enabling initiation specific reactions, such prodrug activation targeted therapy, harmful enhanced synthesis beneficial molecules. Moreover, review systematically explores potential chambers, discussing key aspects their sustained release mechanisms, design strategies, range therapeutic applications. Finally, forward‐looking perspective provided on future addressing broader clinical translation application personalized medicine.
Язык: Английский
Процитировано
0
ACS Sensors, Год журнала: 2025, Номер unknown
Опубликована: Март 19, 2025
With the goal of impacting patient quality life and outcomes, sensor science offers significant potential to revolutionize healthcare by providing advances in detection molecular biomarkers for personalized clinical technologies. The community has achieved technical advancements that can impact diagnostics, health monitoring, disease treatment; however, many innovations remain confined laboratory, failing bridge translational gap between research real-world applications. This perspective presents a new direction community, where development centers on needs experiences primary beneficiaries: patients. We provide guidelines resources researchers engage with patients early continuously throughout process inform specifications better align technologies needs, improving their adoption impact. also present examples implementing patient-centered approach planning engagement research. In design impactful sensors patients, must expand focus beyond embrace approach, which will likely lead opportunities collaboration evolution community.
Язык: Английский
Процитировано
0
Biosensors and Bioelectronics X, Год журнала: 2024, Номер 19, С. 100500 - 100500
Опубликована: Май 23, 2024
Over the last decade, a significant paradigm shift has been observed towards leveraging less invasive biological fluids—such as skin interstitial fluid (ISF), sweat, tears, and saliva—for health monitoring. This evolution seeks to transcend traditional, blood-based methods, offering more accessible approach monitoring for non-specialized personnel. Skin ISF, with its profound resemblance blood, emerges pivotal medium real-time, minimally tracking of broad spectrum biomarkers, thus becoming an invaluable asset correlating data. Our exploration delves deeply into development wearable molecular biosensors, spotlighting dermal sensors their roles across both clinical everyday scenarios underscoring contributions holistic One Health initiative. In bringing forward myriad challenges that permeate this field, we also project future directions, notably potential ISF promising candidate continuous tracking. Moreover, paper aims catalyse further innovation by presenting curated selection seminal technological advancements. Amidst saturated landscape analytical literature on translational challenges, our distinctly highlight recent developments. attracting wider research groups versatile domain, endeavour broaden collective understanding trajectory potential, mapping biosensor technology. strategy not only illuminates transformative impact biosensors in reshaping diagnostics personalized medicine but fosters increased participation progress within field. Distinct from manuscripts review serves distillation key concepts, elucidating papers mark latest advancements sensors. Through collection landmark studies perspectives paths, guide new entrants area. We delineate division between epidermal subdermal sensors—focusing latter frontier—thereby establishing unique discourse ongoing narrative sensing technologies.
Язык: Английский
Процитировано
3
Med-X, Год журнала: 2024, Номер 2(1)
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
2
Korean Journal of Chemical Engineering, Год журнала: 2024, Номер unknown
Опубликована: Окт. 5, 2024
Язык: Английский
Процитировано
1