Biotechnology Journal,
Год журнала:
2024,
Номер
19(10)
Опубликована: Окт. 1, 2024
ABSTRACT
A
new
method
has
been
developed
to
improve
the
detection
of
norovirus
(NoV)
in
complex
fecal
samples
using
nanocatalyst‐based
immunoassays.
The
involves
multifunctional
trimetallic
nanoparticles,
known
as
Ag@Fe
3
O
4
@Au
NPs.
These
nanoparticles
consist
a
core
silver
(Ag)
and
shell
iron
oxide
(Fe
)
decorated
with
isolated
gold
(Au
NPs).
have
enhanced
catalytic
activity,
making
them
an
ideal
nanocatalyst
for
reducing
4‐nitrophenol
(4‐NP,
yellow)
4‐aminophenol
(4‐AP,
colorless).
NPs‐based
immunoassay
achieved
limit
(LOD)
1.9
pg/mL
norovirus‐like
particles
(NoV‐LP)
6.97
RNA
copy
number/mL
NoV.
In
sample
analysis
NoV,
heat
treatment
at
65°C
was
necessary
prevent
degradation
target
protein,
ensuring
sensitive
detection.
This
work
successfully
combined
nanocatalysts
advanced
immunoassays,
which
could
contribute
developing
nano‐biosensing
platforms.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 24, 2024
Abstract
Most
self‐powered
electrochemical
sensors
(SPESs)
are
limited
by
low
open
circuit
voltage
and
power
density,
leading
to
a
narrow
detection
range
sensitivity.
Herein,
photoinduced
Zn‐air
battery‐assisted
SPES
(ZAB‐SPES)
is
proposed
based
on
cobalt
sulfur
co‐doped
carbon
nitride
with
the
cyano
group
(Co,
S‐CN).
The
functionalization
remarkably
enhances
visible
light
utilization,
moiety
acts
as
an
electron‐withdrawing
promote
electron
enrichment.
Co
S
co‐doping
can
create
p–n
homojunction
within
nitride,
enabling
efficient
migration
separation
of
carriers,
thereby
significantly
improving
performance
oxygen
reduction
reaction.
synergistic
effects
endow
Co,
S‐CN
photocathode
1.85
V
maximum
density
43.5
µW
cm
−2
in
ZAB.
Employing
heavy
metal
copper
ions
target
model,
ZAB‐SPES
exhibited
dual‐mode
sensitive
detection.
Furthermore,
portable
device
designed
exhibits
high
linearity
5
~
600
n
M
limit
1.7
.
This
work
offers
method
aquatic
environment.
ACS Materials Letters,
Год журнала:
2024,
Номер
6(10), С. 4581 - 4589
Опубликована: Сен. 3, 2024
Reasonable
design
of
semiconductors
is
crucial
for
improving
the
sensitivity
self-powered
photoelectrochemical
(PEC)
sensors.
In
this
study,
metal
salt-based
deep
eutectic
solvents
(DES(CC-V))
were
self-assembled
on
molten
salt-assisted
carbon
nitride
via
hydrogen
bonding,
forming
a
DES(CC-V)/KCN
homojunction.
The
homojunction
exhibits
negative
conduction
band
position
and
facilitates
directional
electron
transfer
separation.
modification
with
DES(CC-V)
increases
oxygen
active
sites
hydroxyl
amount,
enhancing
hydrophilicity.
synergistic
effect
transport,
sites,
hydrophilicity
promotes
photocatalytic
reduction
reaction,
thus
amplifying
open
circuit
potential
power
density
system.
A
sensing
showcased
high
sensitivity,
stability,
applicability
lead
ions
in
water
environment
achieved
portable
monitoring
multimeter
device
limit
detection
(0.4
ng
L–1).
This
research
proposes
novel
green
synthesis
strategy
salt-DES
modified
to
form
enrich
surface
functionalization.
With
the
goal
of
impacting
patient
quality
life
and
outcomes,
sensor
science
offers
significant
potential
to
revolutionize
healthcare
by
providing
advances
in
detection
molecular
biomarkers
for
personalized
clinical
technologies.
The
community
has
achieved
technical
advancements
that
can
impact
diagnostics,
health
monitoring,
disease
treatment;
however,
many
innovations
remain
confined
laboratory,
failing
bridge
translational
gap
between
research
real-world
applications.
This
perspective
presents
a
new
direction
community,
where
development
centers
on
needs
experiences
primary
beneficiaries:
patients.
We
provide
guidelines
resources
researchers
engage
with
patients
early
continuously
throughout
process
inform
specifications
better
align
technologies
needs,
improving
their
adoption
impact.
also
present
examples
implementing
patient-centered
approach
planning
engagement
research.
In
design
impactful
sensors
patients,
must
expand
focus
beyond
embrace
approach,
which
will
likely
lead
opportunities
collaboration
evolution
community.
