A Patient-Centered Approach in Sensor Science: Embracing Patient Engagement for Translational Clinical Technologies
ACS Sensors,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
With
the
goal
of
impacting
patient
quality
life
and
outcomes,
sensor
science
offers
significant
potential
to
revolutionize
healthcare
by
providing
advances
in
detection
molecular
biomarkers
for
personalized
clinical
technologies.
The
community
has
achieved
technical
advancements
that
can
impact
diagnostics,
health
monitoring,
disease
treatment;
however,
many
innovations
remain
confined
laboratory,
failing
bridge
translational
gap
between
research
real-world
applications.
This
perspective
presents
a
new
direction
community,
where
development
centers
on
needs
experiences
primary
beneficiaries:
patients.
We
provide
guidelines
resources
researchers
engage
with
patients
early
continuously
throughout
process
inform
specifications
better
align
technologies
needs,
improving
their
adoption
impact.
also
present
examples
implementing
patient-centered
approach
planning
engagement
research.
In
design
impactful
sensors
patients,
must
expand
focus
beyond
embrace
approach,
which
will
likely
lead
opportunities
collaboration
evolution
community.
Язык: Английский
Adding a Twist to Lateral Flow Immunoassays: A Direct Replacement of Antibodies with Helical Affibodies, from Selection to Application
Journal of the American Chemical Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Immunoreagents,
most
commonly
antibodies,
are
integral
components
of
lateral
flow
immunoassays.
However,
the
use
antibodies
comes
with
limitations,
particularly
relating
to
their
reproducible
production,
and
poor
thermal
chemical
stability.
Here,
we
employ
phage
display
develop
affibodies,
a
class
nonimmunoglobulin
affinity
proteins
based
on
small
three-helix
bundle
scaffold,
against
SARS-CoV-2
Spike
protein.
Subsequently,
demonstrate
utility
viability
affibodies
directly
replace
in
In
addition,
highlight
several
physiochemical
advantages
including
ability
withstand
exposure
high
temperature
humidity
while
maintaining
superior
performance
compared
antibody
counterparts.
Furthermore,
investigate
adsorption
mechanism
surface
gold
nanoparticle
probes
via
His6-tag,
introduced
also
facilitate
recombinant
purification.
Through
molecular
dynamics
simulations,
elucidate
structural
physical
characteristics
affibody
dimers
which
result
high-performing
detection
when
immobilized
surfaces.
This
work
demonstrates
that
can
be
used
as
direct
replacements
immunoassays
should
further
considered
alternatives
owing
improved
properties
modular
design.
Язык: Английский