Recent Progress in Semi‐Implantable Bioelectronics for Precision Health Monitoring
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
Abstract
Driven
by
the
growing
burden
of
chronic
diseases
and
limited
public
healthcare
resources,
portable
health
monitoring
platforms
are
widely
developed
to
enable
continuous
timely
dissemination
provide
users
with
management
disease
prevention.
However,
it
is
still
a
challenge
for
precision
fully
bio‐integrated
electronic
devices
achieve
stable
physiological
signal
recording
over
long
periods
time.
Recently,
semi‐implantable
bioelectronics
(SI‐bioelectronics)
have
excelled
in
real‐time,
long‐term,
high‐sensitivity
pathological
signals
minimal
invasiveness,
enabled
precise
microneedle
sensing
probes.
In
this
review,
comprehensive
overview
recent
advancements
SI‐bioelectronics
provided,
focus
on
their
structures,
design
considerations,
performances
biochemical
indicators,
bioelectrical
signals,
biomechanical
signals.
Opportunities
research
such
as
smart
medicine
Internet
Things
also
discussed,
which
will
drive
toward
intelligence
efficiency.
Язык: Английский
A Patient-Centered Approach in Sensor Science: Embracing Patient Engagement for Translational Clinical Technologies
ACS Sensors,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
With
the
goal
of
impacting
patient
quality
life
and
outcomes,
sensor
science
offers
significant
potential
to
revolutionize
healthcare
by
providing
advances
in
detection
molecular
biomarkers
for
personalized
clinical
technologies.
The
community
has
achieved
technical
advancements
that
can
impact
diagnostics,
health
monitoring,
disease
treatment;
however,
many
innovations
remain
confined
laboratory,
failing
bridge
translational
gap
between
research
real-world
applications.
This
perspective
presents
a
new
direction
community,
where
development
centers
on
needs
experiences
primary
beneficiaries:
patients.
We
provide
guidelines
resources
researchers
engage
with
patients
early
continuously
throughout
process
inform
specifications
better
align
technologies
needs,
improving
their
adoption
impact.
also
present
examples
implementing
patient-centered
approach
planning
engagement
research.
In
design
impactful
sensors
patients,
must
expand
focus
beyond
embrace
approach,
which
will
likely
lead
opportunities
collaboration
evolution
community.
Язык: Английский
Reproducible Transpalpebral Intraocular Pressure Sensing Enabled by Low-Energy-Barrier Ion Pumping
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 6, 2025
Elevated
intraocular
pressure
(IOP)
is
a
major
risk
factor
for
blindness
in
glaucoma
patients,
highlighting
the
critical
need
continuous
IOP
monitoring.
While
traditional
transpalpebral
tonometers
(TTs)
circumvent
corneal
contact
by
adopting
Goldmann
applanation
principles
through
impulsive
flattening
forces,
their
measurement
accuracy
inherently
compromised
eyelid-induced
cushion
effects.
In
contrast,
parallel-plate
capacitive
sensors
employ
constant
compressive
loading
upon
eyelid,
achieving
palpebral
compaction
to
mitigate
More
recently,
ion-pump-based
have
emerged
as
promising
alternatives,
particularly
due
enhanced
sensitivity.
Nevertheless,
these
exhibit
sharp
sensitivity
deterioration
at
extended
ranges
(0-10
kPa).
This
operational
constraint
originates
from
strong
hydrogen
bond
energies
(between
confining
matrices
and
ions)
rigid
block
copolymer
matrices'
steric
hindrance.
To
address
limitations,
we
developed
tonometer
featuring
low-energy-barrier
ion
pumps,
incorporating
(3-aminopropyl)triethoxysilane
(APTES)-silanized
liquid
metal
nanoparticles
(LM
NPs)
an
ionic
donor.
The
low-energy
barrier
arises
(1)
weaker
bonds
between
N-H
of
APTES
F
(2)
reduced
crystallinity
elastomeric
induced
LM
NPs.
Our
sensor
achieves
24.88
kPa-1
with
maintained
linearity
over
0-85
kPa.
vivo
animal
trials
120
min
validated
its
monitoring
capability,
reliably
detecting
elevated
states
demonstrating
clinical
potential
management.
Язык: Английский