Sustainability Assessment of Mechanochemistry by Using the Twelve Principles of Green Chemistry

ChemSusChem, Год журнала: 2021, Номер 14(10), С. 2145 - 2162

Опубликована: Апрель 9, 2021

In recent years, mechanochemistry has been growing into a widely accepted alternative for chemical synthesis. addition to their efficiency and practicality, mechanochemical reactions are also recognized sustainability. The association between Green Chemistry often originates from the solvent-free nature of most protocols, which can reduce waste production. However, satisfies more than one Principles Chemistry. this Review we will present series examples that clearly illustrate how significantly contribute fulfillment in holistic manner.

Язык: Английский

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Liquid‐Assisted Grinding Mechanochemistry in the Synthesis of Pharmaceuticals

Advanced Synthesis & Catalysis, Год журнала: 2021, Номер 363(5), С. 1246 - 1271

Опубликована: Янв. 21, 2021

Abstract Mechanochemical reactions by milling, grinding or other types of mechanical action have emerged as a salient green approach because its wide applications towards academic and industrial chemical communities in sustainable solvent‐free/solvent‐less processes. Liquid‐assisted (LAG) an extension traditional solvent‐free mechanochemical techniques which small amount liquid is used additive to enhance and/or control reactivity, has been fruitfully applied the screening inclusion compounds, cocrystals, salts, solvates, polymorphs. However, utilization this important technique synthesis pharmaceutically biologically relevant targets was not adequately investigated. This review article summarizes overview latest development LAG approaches active pharmaceutical ingredients (API) drug‐like fragments, highlights superiority versus conventional syntheses. magnified image

Язык: Английский

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Mechanochemistry: New Tools to Navigate the Uncharted Territory of “Impossible” Reactions

ChemSusChem, Год журнала: 2022, Номер 15(17)

Опубликована: Июль 21, 2022

Mechanochemical transformations have made chemists enter unknown territories, forcing a different chemistry perspective. While questioning or revisiting familiar concepts belonging to solution chemistry, mechanochemistry has broken new ground, especially in the panorama of organic synthesis. Not only does it foster "thinking outside box", but also opened reaction paths, allowing overcome weaknesses traditional exactly where use well-established solution-based methodologies rules out progress. In this Review, reader is introduced an intriguing research subject not yet fully explored and waiting for improved understanding. Indeed, study mainly focused on that, although impossible solution, become possible under mechanochemical processing conditions, simultaneously entailing innovation expanding chemical space.

Язык: Английский

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Green metrics in mechanochemistry

Chemical Society Reviews, Год журнала: 2023, Номер 52(19), С. 6680 - 6714

Опубликована: Янв. 1, 2023

The quantitative assessment of the greenness mechanochemical processes for green metrics were calculated is herein reported. A general introduction to topic, variables influencing reaction outcome and, an outlook are also provided.

Язык: Английский

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Mechanochemistry Can Reduce Life Cycle Environmental Impacts of Manufacturing Active Pharmaceutical Ingredients

ACS Sustainable Chemistry & Engineering, Год журнала: 2022, Номер 10(4), С. 1430 - 1439

Опубликована: Янв. 20, 2022

The scale-up of mechanochemical methods could play a transformative role in making manufacturing processes the pharmaceutical industry greener by eliminating solvent use and recovery. Combined with energy-efficient continuous processing that consolidates reaction steps, mechanochemistry's environmental economic benefits may translate across product supply chains. Here, we evaluate numerous sustainability green chemistry metrics for producing nitrofurantoin, an active ingredient (API), via twin-screw extrusion (TSE) conventional solvent-batch synthesis methods. We find significant reduction all TSE including energy, climate change, human ecological health, as well cost due to reducing excess reactant consumption solvents while maintaining high selectivity. In addition, replacing direct energy source drive chemical from mostly thermal electrical sources does not increase net life cycle consumed produce functionally equivalent API. conclude holds multiple APIs potentially other products.

Язык: Английский

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Salient Achievements in Synthetic Organic Chemistry Enabled by Mechanochemical Activation

Synthesis, Год журнала: 2023, Номер 55(16), С. 2439 - 2459

Опубликована: Май 3, 2023

Abstract Although known for millennia, it is only recently that mechanochemistry has received serious attention by chemists. Indeed, during the past 15 years an extraordinary number of reports concerning solid-state chemical transformations through grinding and milling techniques have been recorded. This short review discusses circumstances led this renaissance, highlighting present intense interest in so-called green chemistry, enabling capacity to handle insoluble substrates, identification profound influence additives can on mechanochemically activated reactions. The core account focuses salient developments synthetic organic especially amino acid peptide­ mechanosynthesis, successful employment mechanochemical activation combination with asymmetric organocatalysis, promising enzymatic whole cell biocatalysis, remarkable achievement multicomponent selective reactions via complex, multistep reaction pathways, mechanosynthesis representative heterocycles. final section comments some pending tasks area, such as scaling-up processes be practical use industry, requirement easier more efficient control parameters monitoring devices, consequently careful analysis additional procedures a proper understanding phenomena. 1 Introduction 2 Brief History Mechanochemistry 3 Milling Equipment Reaction Parameters 4 Attributes That Propelled Its Present Renaissance 4.1 Enormous Attention Being Presently Paid Sustainable Chemistry 4.2 Reduced Energy Consumption 4.3 Additive-Based 4.4 Handling Insoluble Reactants 4.5 ‘Impossible’ Reactions Are Successful 4.6 Air- Water-Sensitive Reagents Ball 5 Salient Developments Mechanochemical Activation Synthetic Organic 5.1 Amino Acid Peptide Mechanosynthesis 5.2 Asymmetric Synthesis Organocatalysis under Ball-Milling Conditions 5.3 Mechanoenzymology 5.4 Multicomponent Activated 5.5 Heterocycles Modification 6 Future Directions 6.1 Scaling-Up Protocols 6.2 Temperature-Controlled 6.3 Understanding Transformations 6.4 Emerging Techniques 7 Conclusions

Язык: Английский

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Greening the synthesis of peptide therapeutics: an industrial perspective

RSC Advances, Год журнала: 2020, Номер 10(69), С. 42457 - 42492

Опубликована: Янв. 1, 2020

This review highlights the efforts made to date promote greener peptide synthesis, from an industrial perspective.

Язык: Английский

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Solvent-Free, Continuous Synthesis of Hydrazone-Based Active Pharmaceutical Ingredients by Twin-Screw Extrusion

ACS Sustainable Chemistry & Engineering, Год журнала: 2020, Номер 8(32), С. 12230 - 12238

Опубликована: Авг. 5, 2020

Twin-screw extrusion (TSE) was used to synthesize hydantoin-based active pharmaceutical ingredients (APIs) such as nitrofurantoin and dantrolene, employing minimal or no solvent. Postsynthetic workup not required. This work demonstrates that solvent-free synthesis can be conducted in a continuous manner for products.

Язык: Английский

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Highly Efficient Solid‐State Hydrolysis of Waste Polyethylene Terephthalate by Mechanochemical Milling and Vapor‐Assisted Aging

ChemSusChem, Год журнала: 2020, Номер 14(1), С. 330 - 338

Опубликована: Сен. 28, 2020

Abstract Despite significant methodological and technological advancements in chemical recycling of synthetic polymers, an efficient quantitative conversion post‐consumer polyethylene terephthalate (PET) into terephthalic acid (TPA) under ambient conditions temperature pressure still remains a challenge. In this respect, the application mechanochemistry multiple advantages offered by solid‐state ball milling vapor‐assisted aging have remained insufficiently explored. To further expand their potential, implementation organic solvent‐free as superior methodology for successful alkaline depolymerization waste PET (e. g., bottles textile) TPA monomer near‐quantitative yields was reported herein. The hydrolysis also shown to proceed excellent humid environment or presence alcohol vapors. Moreover, performance mechanochemical gram‐scale demonstrated.

Язык: Английский

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Role of Mixing and Milling in Mechanochemical Synthesis (Review)

Russian Journal of Inorganic Chemistry, Год журнала: 2021, Номер 66(3), С. 433 - 453

Опубликована: Март 1, 2021

Язык: Английский

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