Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide DOI Creative Commons
Matthieu Lavayssiere, Frédéric Lamaty

Chemical Communications, Год журнала: 2023, Номер 59(23), С. 3439 - 3442

Опубликована: Янв. 1, 2023

The solventless synthesis of an amide was performed in a twin-screw extruder the presence coupling agent, providing high yielding and productive method. reaction conditions were optimized to prepare APIs, teriflunomide moclobemide.

Язык: Английский

Mechanochemical methods for the transfer of electrons and exchange of ions: inorganic reactivity from nanoparticles to organometallics DOI
Blaine G. Fiss, Austin J. Richard, Georgia Douglas

и другие.

Chemical Society Reviews, Год журнала: 2021, Номер 50(14), С. 8279 - 8318

Опубликована: Янв. 1, 2021

For inorganic metathesis and reduction reactivity, mechanochemistry is demonstrating great promise towards both nanoparticles organometallics syntheses.

Язык: Английский

Процитировано

43

Re-thinking organic synthesis: Mechanochemistry as a greener approach DOI
Claudia Espro, Daily Rodríguez‐Padrón

Current Opinion in Green and Sustainable Chemistry, Год журнала: 2021, Номер 30, С. 100478 - 100478

Опубликована: Март 19, 2021

Язык: Английский

Процитировано

42

Assessing the Greenness of Mechanochemical Processes with the DOZN 2.0 Tool DOI

Pankaj Sharma,

Caleb Vetter,

Ettigounder Ponnusamy

и другие.

ACS Sustainable Chemistry & Engineering, Год журнала: 2022, Номер 10(16), С. 5110 - 5116

Опубликована: Март 10, 2022

As the demand increases for more sustainable chemical production, mechanochemical processes have been proposed as greener alternatives to traditional manufacturing methods. To support transition processes, quantitative assessment methods must be developed measure and compare greenness of processes. MilliporeSigma's DOZN 2.0 Green Chemistry Evaluator was utilized quantify adherence 12 Principles synthesis Active Pharmaceutical Ingredient (API) nitrofurantoin in batch continuous Through this analysis, SPEX mill twin-screw extrusion (TSE) were shown compared a commercial solution-based process. This conclusion result scores which demonstrated TSE having increased energy efficiency, improved resources use, reduced human environmental hazards other

Язык: Английский

Процитировано

36

Catalyst-free mechanochemistry as a versatile tool in synthetic chemistry: a review DOI
Bandameeda Ramesh Naidu,

Thondooru Sruthi,

Raghavender Mitty

и другие.

Green Chemistry, Год журнала: 2023, Номер 25(16), С. 6120 - 6148

Опубликована: Янв. 1, 2023

This article presents a review of the reports on catalyst-free mechanochemical organic transformations and ability to initiate reactions that are extremely difficult/impossible occur is notable advancement process.

Язык: Английский

Процитировано

23

Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide DOI Creative Commons
Matthieu Lavayssiere, Frédéric Lamaty

Chemical Communications, Год журнала: 2023, Номер 59(23), С. 3439 - 3442

Опубликована: Янв. 1, 2023

The solventless synthesis of an amide was performed in a twin-screw extruder the presence coupling agent, providing high yielding and productive method. reaction conditions were optimized to prepare APIs, teriflunomide moclobemide.

Язык: Английский

Процитировано

20