Nanosecond‐pulsed microbubble plasma reactor for plasma‐activated water generation and bacterial inactivation

Plasma Processes and Polymers, Год журнала: 2022, Номер 19(6)

Опубликована: Март 26, 2022

Abstract In this study, a microbubble‐enabled plasma reactor driven by nanosecond‐pulsed generator was developed to provide an effective means for transferring highly reactive species into liquids plasma‐activated water (PAW) production. The physicochemical characteristics of PAW at different temperatures were evaluated, and the corresponding antimicrobial effects against Escherichia coli cells investigated. Results show that lower temperature (10°C) had highest activity, resulting in 2.43 ± 1.02‐log 10 reduction E. PAW. excellent energy efficiency total oxygen nitrogen production is 10.37 g kW −1 h . Overall, study provides much‐needed insights chemistries optimizing biochemical activity

Язык: Английский

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Effective Photocatalytic Initiation of Reactive Oxygen Species by a Photoactive Covalent Organic Framework for Oxidation Reactions

ACS Materials Letters, Год журнала: 2022, Номер 4(6), С. 1160 - 1167

Опубликована: Май 17, 2022

Reactive oxygen species (ROS) play a vital role in both chemistry and physiology. Developing effective photocatalysts becomes feasible approach to trigger the generation of ROS. Herein, photosensitive covalent organic framework (COF) was rationally designed constructed by incorporating photoactive triphenylamine moieties into its skeleton, characterizations which not only showed success formation highly crystalline stable framework, but also revealed property derived from triphenylamine-based building block. Electron paramagnetic resonance measurements displayed that COF an photocatalyst for generating ROS with one unpaired electron, is, superoxide radical anion (O2• –). Subsequently, high efficiency, selectivity, reusability photocatalytic aerobic oxidation sulfides confirmed is promising applications ROS-involved reactions, demonstrating precisely embedding photochromic groups COFs could be powerful strategy fabricate metal-free heterogeneous targeted reactions.

Язык: Английский

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Achmatowicz Rearrangement-Inspired Development of Green Chemistry, Organic Methodology, and Total Synthesis of Natural Products

Accounts of Chemical Research, Год журнала: 2022, Номер 55(16), С. 2326 - 2340

Опубликована: Авг. 2, 2022

ConspectusThe six-membered heterocycles containing oxygen and nitrogen (tetrahydropyrans, pyrans, piperidines) are among the most common heterocyclic structures ubiquitously present in bioactive molecules such as carbohydrates, small-molecule drugs, natural products. Chemical synthesis of fully functionalized pyrans piperidines is a research theme practical importance scientific significance and, thus, has attracted continuous interest from synthetic chemists. Among numerous approaches, Achmatowicz rearrangement (AchR) represents general unique strategy that uses biomass-derived furfuryl alcohols renewable starting material to obtain oxygen/nitrogen heterocycles, which provides golden opportunities for organic chemists address various challenges.This Account summarizes our 10 years work on exploiting AchR some challenges ranging green chemistry methodology total We enabled sustainable safe use small (academia) or large (industrial) scale by developing two generations approaches (oxone-halide Fenton-halide), largely eliminate popular, but more toxic expansive, NBS m-CPBA. This triggered intensive new important reactions, particular, halogenation/oxidation reactions involving reactive halogenating species with aim eliminating commonly used halogen agents elemental bromine, chlorine gas, N-haloamide reagents (NBS, NCS, NIS). successfully employed oxone-halide Fenton-halide alternatives several mechanistically related including arene/alkene halogenation, oxidation oxidative indoles, alcohols/thioacetals, halogenation aldoximes situ generation nitrile oxide. These expected have solid impact future academia industries.We expanded utility exploring transformations products developed cascade reductive ring expansion, deoxygenation/Heck–Matsuda arylation, palladium-catalyzed C-arylation, regiodivergent [3 + 2] cycloaddition 1,3-dicarbonyls. methodologies offer avenue heterocycles.The was demonstrated 28 pyran/piperidine moiety. The AchR-based endows scalability, sustainability, flexibility. scalable lab allow us easily decagrams synthetically valuable and/or low risk cost alcohol/aldehyde.

Язык: Английский

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Intermolecular 1,2,4-Thiadiazole Synthesis Enabled by Enzymatic Halide Recycling with Vanadium-Dependent Haloperoxidases

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

The enzymatic synthesis of heterocycles is an emerging biotechnology for the sustainable construction societally important molecules. Herein, we describe enzyme-mediated strategy oxidative dimerization thioamides enabled by halide recycling vanadium-dependent haloperoxidase enzymes. This approach allows intermolecular biocatalytic bond formation using a catalytic quantity salt and hydrogen peroxide as terminal oxidant. established method applied to diverse range generate corresponding 1,2,4-thiadiazoles in moderate high yields with excellent chemoselectivity. Mechanistic experiments suggest that reaction proceeds through two distinct sulfur halogenation events are critical heterocycle formation. Molecular docking provide insight into reactivity differences between biocatalysts used this study. Finally, developed preparative scale chemoenzymatic anticancer agent penicilliumthiamine B. These studies demonstrate promising platform

Язык: Английский

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Mechanochemical Vicinal Dibromination of Unactivated Alkenes and Alkynes Using Piezoelectric Material as a Redox Catalyst

Organic Letters, Год журнала: 2024, Номер 26(20), С. 4240 - 4245

Опубликована: Май 14, 2024

Mechanoredox chemistry is a rapidly evolving field at the intersection of mechanical forces and chemical reactions. Herein, we have reported vicinal dibromination unsaturated hydrocarbons using piezoelectric material (Li2TiO3) as redox catalyst. Furthermore, reaction can be efficiently scaled up to 10 mmol performed under an air atmosphere room temperature without solvents or external reductants, Li2TiO3 reused multiple times structural change.

Язык: Английский

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Bromide Oxidation: A Safe Strategy for Electrophilic Brominations

European Journal of Organic Chemistry, Год журнала: 2022, Номер 2022(35)

Опубликована: Май 12, 2022

Abstract Bromination of organic substances is still an important reaction in modern synthetic chemistry. In view the increasing demand for sustainable chemistry, oxidative bromination can play role to avoid use hazardous molecular bromine (Br 2 ). this review, a complete overview chemical oxidants will be provided which have been used electrophilic as well radical brominations, starting from less bromide Br(−I); e. g., HBr or salt, with focus on differences caused by choice oxidant.

Язык: Английский

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Recent progress in the oxidative bromination of arenes and heteroarenes

Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 21(8), С. 1571 - 1590

Опубликована: Янв. 1, 2023

This review summarizes recent developments in the field of oxidative preparation bromoarenes and bromoheteroarenes covering from 2012 to 2022.

Язык: Английский

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In-water oxidative Suzuki coupling of arenes and arylboronic acids using H₂O₂ as a terminal oxidant

Green Chemistry, Год журнала: 2023, Номер 25(4), С. 1345 - 1350

Опубликована: Янв. 1, 2023

The development of a new green oxidative coupling arenes with aryl boronic acid, alkenes, and alkynes using water as solvent hydrogen peroxide the terminal oxidant for first time is reported.

Язык: Английский

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Fenton-like chemistry enables catalytic oxidative desulfurization of thioacetals and thioketals with hydrogen peroxide

Green Chemistry, Год журнала: 2022, Номер 24(10), С. 4041 - 4049

Опубликована: Янв. 1, 2022

The catalytic deprotection of thioacetals/thioketals with Fenton-halide [H 2 O /CeBr 3 (cat)]: reactive brominating species (RBS) generated in situ from Fenton-like chemistry are highly effective for the oxidative desulfurization thioacetals and thioketals.

Язык: Английский

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Heterogeneous organophotocatalytic HBr oxidation coupled with oxygen reduction for boosting bromination of arenes

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 4, 2024

Abstract Developing mild photocatalytic bromination strategies using sustainable bromo source has been attracting intense interests, but there is still much room for improvement. Full utilization of redox centers photocatalysts efficient generation Br + species the key. Herein we report heterogenous organophotocatalytic HBr oxidation coupled with oxygen reduction to furnish 2 and H O effective arenes over Al 3 supported perylene-3,4,9,10-tetracarboxylic dianhydride (PTCDA). Mechanism studies suggest that O-vacancy in can provide Lewis-acid-type anchoring sites , enabling unexpected dual-electron transfer from anchored photoexcited PTCDA chemically bound produce . The in-situ generated work together generate HBrO arenes. This provides new insights heterogenization organophotocatalysts not only help improve their stability recyclability, also endow them ability trigger unusual reaction mode via cooperative catalysis supports.

Язык: Английский

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