Industrial & Engineering Chemistry Research,
Год журнала:
2023,
Номер
62(39), С. 15733 - 15751
Опубликована: Сен. 20, 2023
The
use
of
biocatalysts
in
pharmaceutical
production
is
an
important
approach
for
the
industry
to
achieve
green
manufacturing.
Compared
other
lipases,
Candida
antarctica
lipase
B
(CALB)
possesses
numerous
excellent
characteristics
due
its
unique
structure.
It
exhibits
relatively
strong
catalytic
activity
toward
both
water-insoluble
and
water-soluble
substances.
shows
high
selectivity
hydrolysis
organic
synthesis
reactions.
These
properties
are
crucial
drug
synthesis.
However,
current
research
that
CALB
as
a
catalyst
still
faces
challenges
such
cost,
poor
stability,
difficulty
large-scale
production.
Therefore,
this
paper
mainly
explores
advantages
need
be
overcome.
introduces
application
progress
finally
provides
prospect
future
directions,
hoping
provide
appropriate
references
related
research.
Abstract
Friedel‐Crafts
alkylation
and
acylation
reactions
are
important
methodologies
in
synthetic
industrial
chemistry
for
the
construction
of
aryl‐alkyl
aryl‐acyl
linkages
that
ubiquitous
bioactive
molecules.
Nature
also
exploits
these
many
biosynthetic
processes.
Much
work
has
been
done
to
expand
application
enzymes
unnatural
substrates
through
directed
evolution.
The
promise
such
biocatalysts
is
their
potential
supersede
inefficient
toxic
chemical
approaches
reactions,
with
mild
operating
conditions
‐
hallmark
enzymes.
Complementary
created
bio‐hybrid
catalysts
consisting
anchored
into
biomolecular
scaffolds,
which
display
same
desirable
characteristics.
In
this
Review,
we
summarise
efforts,
focussing
on
both
mechanistic
aspects
considerations,
concluding
an
overview
frontiers
field
routes
towards
more
efficient
benign
future
humankind.
Langmuir,
Год журнала:
2024,
Номер
40(35), С. 18377 - 18406
Опубликована: Авг. 22, 2024
Although
Nature's
evolution
and
intelligence
have
gifted
humankind
with
noteworthy
enzyme
candidates
to
simplify
complex
reactions
ultrafast,
overselective,
effortless,
mild
biological
for
millions
of
years,
their
availability
at
minute-scale,
short-range
time-temperature
stability,
purification
costs
hardly
justify
recycling/or
reuse.
Covalent
immobilization,
particularly
via
multipoint
bonds,
prevents
denaturing,
maintains
activities
long-range
time,
pH,
temperature,
makes
catalysts
available
repetitive
usages;
which
attracts
researchers
industries
bring
more
immobilized
contenders
in
science
commercial
progressions.
Inert-support
activation,
the
most
crucial
step,
needs
appropriate
activators;
under
conditions,
activator's
functional
group(s)
still
present
on
activated
support
rapidly
couples
enzyme,
preventing
unfolding
keeping
active
site
alive.
This
review
summarizes
exciting
experimental
advances,
from
1950s
until
today,
activation
strategies
various
inert
supports
five
different
surface
activators,
cyanogen
bromide,
isocyanate/isothiocyanate,
glutaraldehyde,
carbodiimide
(with
or
without
Pharmaceuticals,
Год журнала:
2021,
Номер
14(10), С. 1043 - 1043
Опубликована: Окт. 13, 2021
Apart
from
being
one
of
the
most
important
intermediates
in
chemical
synthesis,
broadly
used
formation
C–C
bonds
among
other
processes,
β-dicarbonyl
structure
is
present
a
huge
number
biologically
and
pharmaceutically
active
compounds.
In
fact,
mainly
derived
well-known
antioxidant
capability
associated
with
corresponding
enol
tautomer,
β-diketones
are
valuable
compounds
treatment
many
pathological
disorders,
such
as
cardiovascular
liver
diseases,
hypertension,
obesity,
diabetes,
neurological
inflammation,
skin
fibrosis,
or
arthritis;
therefore,
synthesis
these
structures
an
area
overwhelming
interest
for
organic
chemists.
This
paper
devoted
to
advances
achieved
last
ten
years
preparation
1,3-diketones,
using
different
(Claisen,
hydration
alkynones,
decarboxylative
coupling)
catalytic
(biocatalysis,
organocatalytic,
metal-based
catalysis)
methodologies:
Additionally,
branched
by
means
α-functionalization
non-substituted
1,3-diketones
also
discussed.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(7), С. 3605 - 3605
Опубликована: Март 25, 2022
Environmentally
friendly
and
sustainable
processes
for
the
production
of
active
pharmaceutical
ingredients
(APIs)
gain
increasing
attention.
Biocatalytic
synthesis
routes
with
enzyme
cascades
support
many
stated
green
principles,
example,
reduced
need
solvents
or
biodegradability
enzymes.
Multi-enzyme
reactions
have
even
more
advantages
such
as
shift
equilibrium
towards
product
side,
no
intermediate
isolation,
complex
molecules
in
one
reaction
pot.
Despite
intriguing
benefits,
only
a
few
been
applied
industry
so
far.
However,
several
new
are
currently
being
developed
research
that
could
be
great
importance
to
industry.
Here,
we
present
multi-enzymatic
API
close
an
industrial
application.
Their
performances
comparable
exceed
their
chemical
counterparts.
A
still
development
also
introduced
this
review.
Economic
ecological
considerations
made
some
example
assess
environmental
friendliness
applicability.
Industrial & Engineering Chemistry Research,
Год журнала:
2023,
Номер
62(39), С. 15733 - 15751
Опубликована: Сен. 20, 2023
The
use
of
biocatalysts
in
pharmaceutical
production
is
an
important
approach
for
the
industry
to
achieve
green
manufacturing.
Compared
other
lipases,
Candida
antarctica
lipase
B
(CALB)
possesses
numerous
excellent
characteristics
due
its
unique
structure.
It
exhibits
relatively
strong
catalytic
activity
toward
both
water-insoluble
and
water-soluble
substances.
shows
high
selectivity
hydrolysis
organic
synthesis
reactions.
These
properties
are
crucial
drug
synthesis.
However,
current
research
that
CALB
as
a
catalyst
still
faces
challenges
such
cost,
poor
stability,
difficulty
large-scale
production.
Therefore,
this
paper
mainly
explores
advantages
need
be
overcome.
introduces
application
progress
finally
provides
prospect
future
directions,
hoping
provide
appropriate
references
related
research.
