Condensation of carboxylic acids with amines using the Boc₂O/DMAP system under solvent-free conditions

Organic & Biomolecular Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

We have developed an efficient solvent-free protocol for amide bond formation using Boc 2 O/DMAP, involving the in situ generation of a mixed anhydride and proceeding via sequential mechanism.

Язык: Английский

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Mechanochemical aerobic oxidative Heck coupling by polymer-assisted grinding: cyclodextrin additive facilitating regioselectivity control

Green Chemistry, Год журнала: 2024, Номер 26(10), С. 5890 - 5899

Опубликована: Янв. 1, 2024

A novel approach utilizing the polymer-assisted grinding (POLAG) technique to facilitate regioselective oxidative Heck coupling of aryl boronic acids with electronically unbiased olefins under solvent-free conditions was presented.

Язык: Английский

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Nitrogen-Based Organofluorine Functional Molecules: Synthesis and Applications

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

Fluorine and nitrogen form a successful partnership in organic synthesis, medicinal chemistry, material sciences. Although fluorine-nitrogen chemistry has long rich history, this field received increasing interest made remarkable progress over the past two decades, driven by recent advancements transition metal organocatalysis photochemistry. This review, emphasizing contributions from 2015 to 2023, aims update state of art synthesis applications nitrogen-based organofluorine functional molecules chemistry. In dedicated sections, we first focus on fluorine-containing reagents organized according type groups attached nitrogen, including N-F, N-RF, N-SRF, N-ORF. review also covers nitrogen-linked building blocks, catalysts, pharmaceuticals, agrochemicals, underlining these components' broad applicability growing importance modern

Язык: Английский

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Recent Advances in Fluorination Reactions via De‐Carboxylative and De‐Oxygenative Strategies: A Perspective

The Chemical Record, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Abstract Organic fluorine compounds encompass a vast and diverse variety of species that possess unique biological activity due to the presence atoms. Fluorine is highly electronegative, increases lipophilicity (fat‐solubility) hydrophobicity (water‐repellent nature) molecules, often exhibit remarkable chemical thermal stability. This especially useful in drug design, as it can improve bioavailability pharmaceutical help them interact more effectively with membranes. The growing demand for fluorinated materials science, agrochemicals, medicine has made selective incorporation into organic molecules challenging but necessary component modern synthesis. Development C−F building blocks are invaluable synthesis their ability impart stability, selectivity, reactivity molecules. article provides detailed analysis two popular fluorination processes: deoxyfluorination decarboxyfluorination. Deoxyfluorination process enhancing physicochemical properties by replacing hydroxyl groups Decarboxyfluorination type reaction where transformation carboxylic acid derivatives compounds. various fluorinating reagents, mechanistic processes, synthetic uses substrate scope covered this section. When combined, these novel strategies provide effective focused approaches production bonds, offering resources obtaining review mainly focuses on construction via deoxygenative decarboxylative since 2011. We hope offers conceptual overview inspires further advancements efficient bond.

Язык: Английский

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Chemoselective Cleavage and Transamidation of Tertiary p-Methoxybenzyl Amides under Metal-Free Photoredox Catalysis

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Окт. 21, 2024

A metal-free and mild cleavage of tertiary

Язык: Английский

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1.1 Sulfonyl Fluorides and Acyl Fluorides

Опубликована: Янв. 1, 2024

Abstract Sulfonyl fluorides have numerous applications in both synthetic organic chemistry as fluorinating agents and precursors to sulfur(VI) moieties, chemical biology covalent inhibitors probes. The utility of sulfonyl arises from the properties S—F bond, high bond strength polarization imparts stability chemoselectivity that differentiates this group other halides. Likewise, acyl found widespread use synthesis reactive intermediates. increased toward hydrolysis aminolysis comparison chlorides bromides are a result relative electrostatic C—F bond. In review, we provide an overview approaches these valuable motifs, with focus on versatile easy-to-handle protocols.

Язык: Английский

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N-Acylation Reactions of Amines

Elsevier eBooks, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

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