Based
around
the
idea
of
searching
for
sustainable
alternatives
to
fossil
sources
manufacturing
fuels
and
chemical
products,
this
doctoral
thesis
addresses
development
new
catalytic
processes
centered
on
glycerol
valorization,
which
is
main
by-product
biodiesel
synthesis.In
sense,
aim
focused
using
it
as
a
carbon
source
generate
nitrogen
heterocycles
industrial
interest,
specifically,
produce
2methylpiperazine
2-methylpyrazine.However,
due
low
reactivity
severe
reaction
conditions
necessary
carry
out
transformations
towards
these
N-heterocycles,
previous
detailed
research
optimize
understand
selective
dehydration
process
hydroxyacetone
(or
acetol)
was
undertaken.Through
obtaining
intermediate
compound,
has
been
possible
develop
efficient
production
under
reasonably
moderate
conditions.In
regard,
Cu-Mg-Al
hydrotalcite
precursors
give
rise
family
materials
based
mixed
oxides
capable,
if
their
composition
adequately
optimized,
carrying
acetol
continuously
with
yields
≈40%.In
addition,
catalysts
are
stable
more
than
8
hours
operational
conditions,
showing
excellent
regeneration
capacity
reusability.In
same
way,
through
combination
characterization
studies,
interesting
mix
acid-base
redox
centers
exhibited
by
allowed
advancing
significantly
in
state
art
regarding
understanding
reaction.Hence,
verify
fundamental
role
Cu
species
and,
Cu(I)
present
catalysts,
generation
glyceraldehyde
critical
production.Similarly,
acid
catalyst
facilitate
first
adsorption
glycerol,
thus
accelerating
reaction.However,
need
achieve
higher
productivities
from
stand
chance
succeed
overall
strategy
motivated
study
second
copper
oxide
supported
different
metal
(SiO2,
Al2O3
ZrO2)
combining
Lewis
high
exposure.The
proper
selection
optimization
lead
reaching,
several
them,
60%
much
concentrations
starting
feed.
Molecules,
Год журнала:
2022,
Номер
27(21), С. 7594 - 7594
Опубликована: Ноя. 5, 2022
Dimethindene
is
a
selective
histamine
H1
antagonist
and
commercially
available
as
racemate.
Upon
analyzing
the
synthetic
pathways
currently
for
industrial
preparation
of
dimethindene,
we
set
up
sustainable
approach
synthesis
this
drug,
switching
from
petroleum-based
volatile
organic
compounds
(VOCs)
to
eco-friendly
solvents,
such
2-methyltetrahydrofuran
(2-MeTHF)
cyclopentyl
methyl
ether
(CPME)
belonging
classes
3
2,
respectively.
Beyond
decreasing
environmental
impact
(E-factor:
24.1-54.9
with
VOCs;
12.2-22.1
2-MeTHF
or
CPME),
switch
also
improved
overall
yield
process
(from
10%
VOCs
21-22%
CPME)
remarkably
simplified
manual
operations,
working
under
milder
conditions.
Typical
metrics
applied
at
first
second
pass,
according
CHEM21
toolkit,
were
calculated
whole
procedure
results
compared
those
classical
procedure.
Organic Letters,
Год журнала:
2020,
Номер
22(15), С. 5890 - 5894
Опубликована: Июль 24, 2020
The
polyethylene
glycol
(PEG)
moiety
has
become
increasingly
important
in
medicinal
chemistry.
Herein,
we
describe
the
PEG
functionalization
of
amines
via
hydrogen
borrowing
reductive
amination.
This
was
accomplished
using
[Ru(p-cymene)Cl2]2
catalyst
and
phosphorus-containing
ligand
dppf
or
DPE
to
yield
a
variety
PEGylated
primary
secondary
amine
products.
Furthermore,
illustrate
utility
this
method
with
synthesis
quetiapine
(Seroquel)
62%
isolated
yield.
Microplastic
risk
assessment
and
removal
from
the
environment
require
continuous
improvements
in
extraction
methods,
especially
for
complex
matrices.
Here,
we
firstly
established
that
glycerol
possessed
flotation
capability,
evaluated
correlation
between
time
recovery,
then
applied
newly
developed
method
to
extract
microplastics
soil
samples.
Results
showed
recovery
rates
of
polypropylene
(PP),
polystyrene
(PS),
polyethylene
(PE)
all
experimental
groups
using
ranged
93.33%
±
5.77%
100%.
It
was
demonstrated
has
ability
float
multiple
microplastic
polymers
with
better
than
those
sodium
chloride/iodide.
Additionally,
cost
is
lower,
it
can
be
mixed
iodide
reduce
overall
costs,
making
more
economical
safer
solute.
The
application
this
successfully
extracted
two
polymers,
PP
PS,
at
0.11±0.04
items/g
tidal
flat
Baishamen
three
including
PP,
PE
PVC,
21±0.13
farmland
Hainan,
China.
Therefore,
widely
used
as
a
fluid
extracting
environment,
providing
new
reference
evaluating
pollution.
Based
around
the
idea
of
searching
for
sustainable
alternatives
to
fossil
sources
manufacturing
fuels
and
chemical
products,
this
doctoral
thesis
addresses
development
new
catalytic
processes
centered
on
glycerol
valorization,
which
is
main
by-product
biodiesel
synthesis.In
sense,
aim
focused
using
it
as
a
carbon
source
generate
nitrogen
heterocycles
industrial
interest,
specifically,
produce
2methylpiperazine
2-methylpyrazine.However,
due
low
reactivity
severe
reaction
conditions
necessary
carry
out
transformations
towards
these
N-heterocycles,
previous
detailed
research
optimize
understand
selective
dehydration
process
hydroxyacetone
(or
acetol)
was
undertaken.Through
obtaining
intermediate
compound,
has
been
possible
develop
efficient
production
under
reasonably
moderate
conditions.In
regard,
Cu-Mg-Al
hydrotalcite
precursors
give
rise
family
materials
based
mixed
oxides
capable,
if
their
composition
adequately
optimized,
carrying
acetol
continuously
with
yields
≈40%.In
addition,
catalysts
are
stable
more
than
8
hours
operational
conditions,
showing
excellent
regeneration
capacity
reusability.In
same
way,
through
combination
characterization
studies,
interesting
mix
acid-base
redox
centers
exhibited
by
allowed
advancing
significantly
in
state
art
regarding
understanding
reaction.Hence,
verify
fundamental
role
Cu
species
and,
Cu(I)
present
catalysts,
generation
glyceraldehyde
critical
production.Similarly,
acid
catalyst
facilitate
first
adsorption
glycerol,
thus
accelerating
reaction.However,
need
achieve
higher
productivities
from
stand
chance
succeed
overall
strategy
motivated
study
second
copper
oxide
supported
different
metal
(SiO2,
Al2O3
ZrO2)
combining
Lewis
high
exposure.The
proper
selection
optimization
lead
reaching,
several
them,
60%
much
concentrations
starting
feed.