Catalytic transformations of glycerol via hydroxyacetone into nitrogen heterocycles of industrial interest DOI Creative Commons

Jaime Mazarío Santa-Pau

Опубликована: Дек. 15, 2021

Based around the idea of searching for sustainable alternatives to fossil sources manufacturing fuels and chemical products, this doctoral thesis addresses development new catalytic processes centered on glycerol valorization, which is main by-product biodiesel synthesis.In sense, aim focused using it as a carbon source generate nitrogen heterocycles industrial interest, specifically, produce 2methylpiperazine 2-methylpyrazine.However, due low reactivity severe reaction conditions necessary carry out transformations towards these N-heterocycles, previous detailed research optimize understand selective dehydration process hydroxyacetone (or acetol) was undertaken.Through obtaining intermediate compound, has been possible develop efficient production under reasonably moderate conditions.In regard, Cu-Mg-Al hydrotalcite precursors give rise family materials based mixed oxides capable, if their composition adequately optimized, carrying acetol continuously with yields ≈40%.In addition, catalysts are stable more than 8 hours operational conditions, showing excellent regeneration capacity reusability.In same way, through combination characterization studies, interesting mix acid-base redox centers exhibited by allowed advancing significantly in state art regarding understanding reaction.Hence, verify fundamental role Cu species and, Cu(I) present catalysts, generation glyceraldehyde critical production.Similarly, acid catalyst facilitate first adsorption glycerol, thus accelerating reaction.However, need achieve higher productivities from stand chance succeed overall strategy motivated study second copper oxide supported different metal (SiO2, Al2O3 ZrO2) combining Lewis high exposure.The proper selection optimization lead reaching, several them, 60% much concentrations starting feed.

Язык: Английский

Green Solvents for Eco-Friendly Synthesis of Dimethindene: A Forward-Looking Approach DOI Creative Commons
Andrea Francesca Quivelli, Federico Vittorio Rossi,

Chiara Alario

и другие.

Molecules, Год журнала: 2022, Номер 27(21), С. 7594 - 7594

Опубликована: Ноя. 5, 2022

Dimethindene is a selective histamine H1 antagonist and commercially available as racemate. Upon analyzing the synthetic pathways currently for industrial preparation of dimethindene, we set up sustainable approach synthesis this drug, switching from petroleum-based volatile organic compounds (VOCs) to eco-friendly solvents, such 2-methyltetrahydrofuran (2-MeTHF) cyclopentyl methyl ether (CPME) belonging classes 3 2, respectively. Beyond decreasing environmental impact (E-factor: 24.1-54.9 with VOCs; 12.2-22.1 2-MeTHF or CPME), switch also improved overall yield process (from 10% VOCs 21-22% CPME) remarkably simplified manual operations, working under milder conditions. Typical metrics applied at first second pass, according CHEM21 toolkit, were calculated whole procedure results compared those classical procedure.

Язык: Английский

Процитировано

4
Synthesis of PEG-Functionalized Amines Using Ruthenium-Catalyzed Hydrogen Borrowing DOI
Federico Vittorio Rossi, Jeremy T. Starr,

Daniel P. Uccello

и другие.

Organic Letters, Год журнала: 2020, Номер 22(15), С. 5890 - 5894

Опубликована: Июль 24, 2020

The polyethylene glycol (PEG) moiety has become increasingly important in medicinal chemistry. Herein, we describe the PEG functionalization of amines via hydrogen borrowing reductive amination. This was accomplished using [Ru(p-cymene)Cl2]2 catalyst and phosphorus-containing ligand dppf or DPE to yield a variety PEGylated primary secondary amine products. Furthermore, illustrate utility this method with synthesis quetiapine (Seroquel) 62% isolated yield.

Язык: Английский

Процитировано

5
Development and Application of an Efficient Microplastics Extraction Method Based on Glycerol Flotation for Environmental Soil Samples DOI
Hailong Zhou,

Yingmiao Chen,

Muhammad Junaid

и другие.

Опубликована: Янв. 1, 2024

Microplastic risk assessment and removal from the environment require continuous improvements in extraction methods, especially for complex matrices. Here, we firstly established that glycerol possessed flotation capability, evaluated correlation between time recovery, then applied newly developed method to extract microplastics soil samples. Results showed recovery rates of polypropylene (PP), polystyrene (PS), polyethylene (PE) all experimental groups using ranged 93.33% ± 5.77% 100%. It was demonstrated has ability float multiple microplastic polymers with better than those sodium chloride/iodide. Additionally, cost is lower, it can be mixed iodide reduce overall costs, making more economical safer solute. The application this successfully extracted two polymers, PP PS, at 0.11±0.04 items/g tidal flat Baishamen three including PP, PE PVC, 21±0.13 farmland Hainan, China. Therefore, widely used as a fluid extracting environment, providing new reference evaluating pollution.

Язык: Английский

Процитировано

0
Catalytic transformations of glycerol via hydroxyacetone into nitrogen heterocycles of industrial interest DOI Creative Commons

Jaime Mazarío Santa-Pau

Опубликована: Дек. 15, 2021

Based around the idea of searching for sustainable alternatives to fossil sources manufacturing fuels and chemical products, this doctoral thesis addresses development new catalytic processes centered on glycerol valorization, which is main by-product biodiesel synthesis.In sense, aim focused using it as a carbon source generate nitrogen heterocycles industrial interest, specifically, produce 2methylpiperazine 2-methylpyrazine.However, due low reactivity severe reaction conditions necessary carry out transformations towards these N-heterocycles, previous detailed research optimize understand selective dehydration process hydroxyacetone (or acetol) was undertaken.Through obtaining intermediate compound, has been possible develop efficient production under reasonably moderate conditions.In regard, Cu-Mg-Al hydrotalcite precursors give rise family materials based mixed oxides capable, if their composition adequately optimized, carrying acetol continuously with yields ≈40%.In addition, catalysts are stable more than 8 hours operational conditions, showing excellent regeneration capacity reusability.In same way, through combination characterization studies, interesting mix acid-base redox centers exhibited by allowed advancing significantly in state art regarding understanding reaction.Hence, verify fundamental role Cu species and, Cu(I) present catalysts, generation glyceraldehyde critical production.Similarly, acid catalyst facilitate first adsorption glycerol, thus accelerating reaction.However, need achieve higher productivities from stand chance succeed overall strategy motivated study second copper oxide supported different metal (SiO2, Al2O3 ZrO2) combining Lewis high exposure.The proper selection optimization lead reaching, several them, 60% much concentrations starting feed.

Язык: Английский

Процитировано

0