Chemical Society Reviews,
Год журнала:
2014,
Номер
43(20), С. 6906 - 6919
Опубликована: Янв. 1, 2014
The
use
of
coordinating
moieties
as
directing
groups
for
the
functionalisation
aromatic
carbon-hydrogen
(C-H)
bonds
has
become
an
efficient
strategy
selective
construction
new
carbon-carbon
(C-C)
and
carbon-heteroatom
(C-X)
in
arenes.
However
many
cannot
be
easily
removed/modified
from
products
after
C-H
functionalisation,
thus
limiting
structural
diversity
products.
This
limitation
can
overcome
by
employing
removable/modifiable
or
traceless
which
attached
to
starting
materials
detached
In
this
tutorial
review,
we
give
overview
recent
advances
emerging
field
have
dramatically
increased
synthetic
applicability
processes.
ACS Central Science,
Год журнала:
2016,
Номер
2(5), С. 302 - 308
Опубликована: Май 5, 2016
While
preparative
electrolysis
of
organic
molecules
has
been
an
active
area
research
over
the
past
century,
modern
synthetic
chemists
have
generally
reluctant
to
adopt
this
technology.
In
fact,
electrochemical
methods
possess
many
benefits
traditional
reagent-based
transformations,
such
as
high
functional
group
tolerance,
mild
conditions,
and
innate
scalability
sustainability.
Outlook
we
highlight
illustrative
examples
reactions
in
context
synthesis
complex
molecules,
showcasing
intrinsic
versus
approaches.
Our
hope
is
that
field
will
soon
see
widespread
adoption
community.
Journal of the American Chemical Society,
Год журнала:
2016,
Номер
138(39), С. 12692 - 12714
Опубликована: Сен. 15, 2016
This
Perspective
illustrates
the
defining
characteristics
of
free
radical
chemistry,
beginning
with
its
rich
and
storied
history.
Studies
from
our
laboratory
are
discussed
along
recent
developments
emanating
others
in
this
burgeoning
area.
The
practicality
chemoselectivity
reactions
enable
rapid
access
to
molecules
relevance
drug
discovery,
agrochemistry,
material
science,
other
disciplines.
Thus,
these
reactive
intermediates
possess
inherent
translational
potential,
as
they
can
be
widely
used
expedite
scientific
endeavors
for
betterment
humankind.
Chemical Society Reviews,
Год журнала:
2012,
Номер
41(17), С. 5588 - 5588
Опубликована: Янв. 1, 2012
In
this
tutorial
review,
we
will
summarize
our
recent
efforts
in
transition
metal-catalyzed
oxidative
coupling
via
C-H
functionalization
of
aromatic,
benzylic
and
allylic
bonds.
Related
works
from
other
laboratories
be
cited
where
suitable,
aiming
to
give
the
readers
a
flavor
field.
Special
emphasis
is
placed
on
reaction
design
development.
Chemical Society Reviews,
Год журнала:
2013,
Номер
43(3), С. 901 - 910
Опубликована: Ноя. 11, 2013
Towards
"Oxidative-Ullmann-Goldberg"
and
"Oxidative-Buchwald-Hartwig"
type
amination
reactions.
This
review
focuses
on
the
newly
developed
oxidative
C-N
bond
formation
techniques,
applicable
in
field
of
organic
synthesis.
Particular
emphasis
is
given
to
those
which
are
classified
as
cross-dehydrogenative-couplings,
through
dual
C-H
N-H
activation,
thus
formally
extruding
"H2"
a
by-product.
Advanced Synthesis & Catalysis,
Год журнала:
2014,
Номер
356(7), С. 1461 - 1479
Опубликована: Апрель 30, 2014
Abstract
Synthetically
useful
functional
groups,
including
ketones,
amides,
carbamates,
carboxylic
acids,
aldehydes
or
ethers,
have
been
identified
as
weakly
coordinating
directing
groups
in
efficient
ruthenium(II)‐catalyzed
CH
functionalizations.
This
strategy
set
the
stage
for
versatile
bond
olefinations,
oxygenations,
nitrogenations
and
oxidative
alkyne
annulations
among
others.
Thereby,
step‐economical
access
to
diversely
decorated
arenes
heteroarenes
was
provided
a
sustainable
fashion.
magnified
image
ACS Central Science,
Год журнала:
2016,
Номер
2(5), С. 281 - 292
Опубликована: Май 2, 2016
The
functionalization
of
C–H
bonds
has
created
new
approaches
to
preparing
organic
molecules
by
enabling
strategic
"disconnections"
during
the
planning
a
synthetic
route.
Such
functionalizations
also
have
ability
derivatize
complex
modifying
one
or
more
many
bonds.
For
these
reasons,
researchers
are
developing
types
reactions
and
applications
processes.
These
bond
can
be
divided
into
two
general
classes:
those
directed
coordination
an
existing
functional
group
prior
cleavage
(directed)
occurring
without
(undirected).
undirected
much
less
common
challenging
develop
than
reactions.
This
outlook
will
focus
on
functionalization,
as
well
related
that
occur
noncovalent
association
catalyst
cleavage.
inherent
challenges
conducting
methods
for
being
developed
presented,
along
with
factors
govern
selectivity
in
Finally,
this
discusses
future
directions
research
emphasis
limitations
must
overcome
if
type
methodology
is
become
widely
used
academia
industry.
Left-
or
right-handed
C–H
bond
activation
Although
organic
compounds
consist
mostly
of
carbon
and
hydrogen
atoms,
strategies
for
chemical
synthesis
have
traditionally
targeted
the
handful
more
reactive
interspersed
oxygens,
nitrogens,
halogens.
Modifying
bonds
directly
is
a
appealing
approach,
but
selectivity
remains
challenge.
Saint-Denis
et
al.
review
recent
progress
in
using
transition
metal
catalysis
to
break
just
one
two
mirror-image
then
append
complex
substituent
its
place.
Ligand
design
has
proven
crucial
differentiate
these
otherwise
similar
variety
molecular
settings.
Science
,
this
issue
p.
eaao4798
