Effect of Lipid Nanoparticle Physico-Chemical Properties and Composition on Their Interaction with the Immune System

Pharmaceutics, Год журнала: 2024, Номер 16(12), С. 1521 - 1521

Опубликована: Ноя. 26, 2024

Lipid nanoparticles (LNPs) have shown promise as a delivery system for nucleic acid-based therapeutics, including DNA, siRNA, and mRNA vaccines. The immune plays critical role in the response to these nanocarriers, with innate cells initiating an early adaptive mediating more specific reaction, sometimes leading potential adverse effects. Recent studies that LNPs is mediated by Toll-like receptors (TLRs) other pattern recognition (PRRs), which recognize lipid components of nanoparticles. This can trigger activation inflammatory pathways production cytokines chemokines, effects such fever, inflammation, pain at injection site. On hand, appears be primarily directed against protein encoded cargo, little evidence ongoing LNP itself. Understanding relationship between development safe effective systems. In fact, targeting essential develop vaccines, well therapies cancer or infections. There lack research literature has systematically studied factors influence interaction further needed better elucidate mechanisms underlying LNPs. this review, we discuss LNPs’ composition, physico-chemical properties, size, shape, surface charge, corona formation affect reactivity system, thus providing guide on new formulations could gain favorable efficacy/safety profile.

Язык: Английский

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Active targeting of type 1 diabetes therapies to pancreatic beta cells using nanocarriers

Diabetologia, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Язык: Английский

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The Protein Corona Paradox: Challenges in Achieving True Biomimetics in Nanomedicines

Biomimetics, Год журнала: 2025, Номер 10(5), С. 276 - 276

Опубликована: Апрель 29, 2025

Nanoparticles introduced into biological environments rapidly acquire a coating of biomolecules, forming biocorona that dictates their fate. Among these proteins play key role, but interaction with nanoparticles during the adsorption process often leads to unfolding and functional loss. Evidence suggests protein denaturation within alters cellular recognition, signaling pathways, immune responses, significant implications for nanomedicine nanotoxicology. This review explores dynamic nature corona, emphasizing influence local milieu on its stability. We synthesize findings from studies examining physicochemical properties nanoparticles—such as surface charge, hydrophobicity, curvature—that contribute structural perturbations. Understanding factors governing stability nanoparticle surfaces is essential designing nanomaterials improved targeting, biocompatibility, controlled interactions. underscores importance preserving conformational integrity in development biomedical applications.

Язык: Английский

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Rational development of gemcitabine-based nanoplatform for targeting SERPINB9/Granzyme B axis to overcome chemo-immune-resistance

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Май 5, 2025

Язык: Английский

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