Authorea (Authorea),
Год журнала:
2023,
Номер
unknown
Опубликована: Апрель 21, 2023
The
process
and
mechanism
of
biomineralization
relevant
physicochemical
properties
mineral
crystals
are
remarkably
sophisticated
multidisciplinary
fields
that
include
biology,
chemistry,
physics,
materials
science.
components
the
organic
matter,
structural
construction
minerals,
related
mechanical
interaction,
etc.,
could
help
to
reveal
unique
nature
special
mineralization
process.
Herein,
paper
provides
an
overview
from
perspective
molecular
vibrational
spectroscopy,
including
biomineralized
tissues,
physiological
applied
mineralization.
These
characteristics
closely
hierarchical
biological
crystal
defects,
chemical
bonding,
atomic
doping,
changes,
content
changes
in
along
with
interface
between
biocrystals
matter
as
well
specific
effects
for
hardness
toughness.
Based
on
those
observations,
enamel
bone,
possible
pathological
calcification
such
atherosclerosis,
tumor
micro
mineralization,
urolithiasis
also
reviewed
discussed.
Indeed,
clearly
defined
pave
way
studies
mechanisms
applications.
Abstract
The
process
and
mechanism
of
biomineralization
relevant
physicochemical
properties
mineral
crystals
are
remarkably
sophisticated
multidisciplinary
fields
that
include
biology,
chemistry,
physics,
materials
science.
components
the
organic
matter,
structural
construction
minerals,
related
mechanical
interaction,
etc.,
could
help
to
reveal
unique
nature
special
mineralization
process.
Herein,
paper
provides
an
overview
from
perspective
molecular
vibrational
spectroscopy,
including
biomineralized
tissues,
physiological
applied
mineralization.
These
characteristics
closely
hierarchical
biological
crystal
defects,
chemical
bonding,
atomic
doping,
changes,
content
changes
in
along
with
interface
between
biocrystals
matter
as
well
specific
effects
for
hardness
toughness.
Based
on
those
observations,
enamel
bone,
possible
pathological
calcification
such
atherosclerosis,
tumor
micro
mineralization,
urolithiasis
also
reviewed
discussed.
Indeed,
clearly
defined
pave
way
studies
mechanisms
applications.
Achieving
antitumor
immunotherapy
based
on
hybridization
of
multiple
types
inactivated
cells
has
attracted
a
lot
attention.
However,
the
hybridized
disordered
structure
could
result
in
shedding
antigens
and
their
transfer
to
immune
cells,
which
suppresses
tumor
immunity
through
trogocytosis.
Here,
we
report
strategy
for
situ
solidification
whole
cell
by
biomineralization
sustained
stimulation
immunity.
The
near-infrared
light
was
used
accelerate
breaking
Au=P
bonds
auranofin,
exposed
Au
atoms
biomineralize
at
secondary
(β-corner)
protein
form
nanocrystals
with
coronas
cells.
are
anchored
coronas,
fixes
morphology
rendering
them
physiologically
inactive.
Interestingly,
this
solidified
prevents
from
undergoing
trogocytosis,
inhibits
proximal
distal
growth.
Thus,
study
presents
its
potential
application
immunotherapy.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(14)
Опубликована: Янв. 26, 2024
Biomineral
crystals
form
complex
nonequilibrium
structures
based
on
the
multistep
nucleation
theory,
via
transient
amorphous
precursors.
However,
intricate
nature
of
biological
system
results
in
inconsistent
frequency
and
crystallization,
which
making
it
problematic
to
obtain
homogeneous
nanocrystals,
limits
their
application
biomedicine.
Here,
is
reported
that
nanocrystals
photoinduced
oriented
crystallization
with
protein
coronas
are
intracellular
liquid-liquid
phase
separation
for
situ
analysis
mapping
surface-enhanced
Raman
spectroscopy
(SERS).
Near-infrared
light
promotes
formation
dense
phases,
accelerates
gold
atoms
at
secondary
structure
sites
proteins,
growth
crystals.
Homogeneous
stable
SERS
signals
can
be
used
different
cell
cycles
acquire
molecular
information
metastatic
tumor
cells.
Of
note
tag
molecule
embedded
enable
patient
tissue
samples
portable
recognition
Thus,
this
study
proposes
a
new
strategy
biomineralization
its
potential
application.
Biosensors,
Год журнала:
2024,
Номер
14(2), С. 59 - 59
Опубликована: Янв. 23, 2024
Bacterial
infections
continue
to
pose
a
significant
global
health
challenge,
with
the
emergence
of
multidrug-resistant
(MDR)
bacteria
and
biofilms
further
complicating
treatment
options.
The
rise
pan-resistant
bacteria,
coupled
slow
development
new
antibiotics,
highlights
urgent
need
for
therapeutic
strategies.
Nanotechnology-based
biosensors
offer
fast,
specific,
sensitive,
selective
methods
detecting
treating
bacteria;
hence,
it
is
promising
approach
diagnosis
MDR
bacteria.
Through
mechanisms,
such
as
destructive
bacterial
cell
membranes,
suppression
efflux
pumps,
generation
reactive
oxygen
species,
nanotechnology
effectively
combats
resistance
biofilms.
Nano-biosensors
related
technology
have
demonstrated
their
importance
in
treatment,
providing
innovative
ideas
inhibition.
This
review
focuses
on
multiple
approaches
targeting
eliminating
antimicrobial
biofilms,
highlighting
nano-biosensors
via
photodynamics-based
biosensors,
eletrochemistry
acoustic-dynamics
sensors,
so
on.
Furthermore,
major
challenges,
opportunities
multi-physical-field
biometrics-based
relevant
theranostics
are
also
discussed.
Overall,
this
provides
insights
scientific
references
harness
comprehensive
diverse
capabilities
precise
ABSTRACT
Inorganic
protein
hybrid
materials
(IPHMs)
due
to
editable
structure
present
unrivalled
potential
at
the
intersection
of
synthetic
biology
and
science.
The
synthesis
IPHMs
with
a
high
degree
biosafety
from
bioactive
units
represents
shift
in
material
design
synthesis.
This
paper
focuses
on
review
structural
basis
principles
proteins
for
specific
physical
chemical
functions.
It
also
provides
valuable
reference
emerging
through
conformational
relationship
IPHMs,
which
extends
applications
IPHMs.
In
addition,
construction
strategy
reaction
system
is
analyzed
perspective
biology.
possibility
engineering
batch
discussed.
Based
physicochemical
properties
different
applied‐oriented
research
biomedical
optical
imaging
multimodal
therapy,
idea
situ
proposed.
Ultimately,
trends
challenges
are
speculated
detail.
Chinese Journal of Chemistry,
Год журнала:
2023,
Номер
41(18), С. 2382 - 2399
Опубликована: Май 3, 2023
Comprehensive
Summary
Stimuli‐controlled
disassembly
process
has
shown
promise
to
direct
delivery
of
probes
and/or
spatial‐temporally
control
imaging
signals
for
molecular
in
vivo
.
Via
the
process,
well
defined
nanoprobes
with
a
stimulus‐responsive
moiety
can
be
controllably
converted
into
small‐molecular
agents
response
stimulus,
leading
switch
signals.
Moreover,
on‐site
released
small‐molecule
could
enhance
penetration
deep
tissue
improved
deep‐seated
targets.
Therefore,
such
stimuli‐controllable
approach
been
widely
utilized
build
activatable
noninvasive
detection
various
targets
living
subjects.
In
this
review
article,
we
first
briefly
introduce
general
principle
stimuli‐controlled
disassembly.
We
then
summarize
based
on
different
internal
or
external
stimulus
that
process.
Activatable
by
using
multiple
stimuli
cascaded
situ
self‐assembly
and
processes
are
also
discussed.
Finally,
close
conclusion
current
challenges
perspective
field.
wish
paper
will
give
readers
useful
information
via
intelligent
