Applications of Aggregation-Induced Emission Materials in Immunology: From Diagnostics to Immunotherapy
Chemical & Biomedical Imaging,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Aggregation-induced
emission
(AIE)
materials,
due
to
their
unique
ability
significantly
enhance
optical
in
aggregated
states,
have
demonstrated
vast
potential
immunology,
particularly
early
disease
diagnosis
and
immunotherapy.
AIE
materials
can
serve
as
highly
efficient
fluorescent
probes
for
biomarker
detection,
providing
critical
insights
diagnosis.
Additionally,
they
act
cancer
vaccines,
enhancing
the
effectiveness
of
immunotherapy
through
photodynamic
therapy,
photothermal
or
activation
immune
cells.
This
review
highlights
applications
focusing
on
recent
advancements
diagnostics
while
also
discussing
challenges
face
directions
future
development.
Язык: Английский
808 nm Light-Triggered Cyanine-Decorated Iridium(III) Complexes for Antibacterial Photodynamic Therapy in Deep-Tissue
Inorganic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 11, 2025
Acute
bacterial
skin
and
structure
infections
(ABSSSIs)
pose
significant
global
health
challenges,
exacerbated
by
rising
antibiotic
resistance.
Antibacterial
photodynamic
therapy
(APDT)
has
emerged
as
a
promising
strategy
to
combat
these
utilizing
photosensitizer
(PS)
that
generates
reactive
oxygen
species
(ROS)
upon
light
activation.
However,
the
limited
tissue
penetration
of
conventional
organic
PSs,
which
primarily
absorb
in
UV-vis
spectra,
hindered
their
therapeutic
potential
for
deeper
infections.
Herein,
we
introduce
novel
iridium(III)-cyanine
complex
(Ir-cy)
with
strong
near-infrared
(NIR)
absorption
at
814
nm
(up
101
red-shifted
from
previous
reports),
specifically
designed
enhance
APDT.
Under
808
laser
irradiation,
Ir-cy
demonstrated
substantial
ROS
generation
capacity,
achieving
approximately
70%
reduction
Staphylococcus
aureus
(S.
aureus)
colonies
depth
7.2
mm
within
simulated
model.
Comprehensive
vitro
vivo
evaluations
further
confirmed
its
potent
antibacterial
efficacy
against
S.
while
maintaining
excellent
biocompatibility.
These
findings
highlight
highly
effective
NIR-active
PS,
paving
way
advanced
strategies
targeting
deep-tissue
ABSSSIs
through
optimized
Язык: Английский
A Biocompatible Phosphorescence Probe Based on Iridium(III) Solvent Complex for Monitoring Integrin Expression in Living Cells
Talanta,
Год журнала:
2025,
Номер
293, С. 128158 - 128158
Опубликована: Апрель 15, 2025
Язык: Английский
Screening Anti-Parkinson’s Disease Drugs in Living Mouse Brains via a Peroxynitrite-Activated Fluorescent Probe
Chemical & Biomedical Imaging,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Screening
anti-Parkinson's
disease
(PD)
drugs
at
in
vivo
brain
level
is
imperative
for
managing
PD
yet
currently
remains
unaccomplished.
Peroxynitrite
(ONOO–)
has
been
implicated
progression.
Thus,
developing
ONOO–-based
imaging
tools
anti-PD
drug
screening
holds
promise
early
prognosis
and
treatment
of
PD.
Consequently,
a
near-infrared
(NIR)
fluorescence
probe,
BOB-Cl-PN,
with
high
specificity,
good
sensitivity
(LOD
=
24
nM),
rapid
response
(<60
s),
was
devised
to
investigate
ONOO–
relationships.
Utilizing
NIR
imaging,
BOB-Cl-PN
effectively
monitored
fluctuations
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP)-induced
cell
models,
establishing
cellular
throughput
(cHTS)
system
drugs.
In
live
animal
BOB-Cl-PN's
ability
penetrate
the
blood–brain
barrier
enabled
flux
mouse
brains.
Moreover,
served
as
an
contrast
potential
traditional
Chinese
medicines
therapy,
identifying
fisetin
having
best
therapeutic
index
among
10
medicines.
This
study
constructs
sensitive,
efficient
monitoring
dynamics
brains
provides
valuable
platform
Язык: Английский
A DMSO-assisted iridium(iii) complex as a luminescent “turn-on” sensor for selective detection of l-histidine and bacterial imaging
Analytical Methods,
Год журнала:
2024,
Номер
16(40), С. 6839 - 6844
Опубликована: Янв. 1, 2024
Histidine
(His)
is
a
semi-essential
amino
acid
and
unique
key
neurotransmitter
involved
in
numerous
physiological
processes.
An
excessive
or
deficient
amount
of
His
the
body
can
lead
to
various
related
diseases.
However,
since
chemical
structures
L-His
its
metabolites
(such
as
histamine
(Ha),
imidazole-4-acetate
(ImA),
etc.)
are
very
similar,
simple
efficient
selective
detection
great
importance
but
remains
challenge.
Herein,
we
successfully
designed
synthesized
DMSO-assisted
iridium(III)
complex
(Ir1-DMSO),
which
be
applied
"turn-on"
photoluminescence
(PL)
probe
for
quantification
L-His/Ha.
More
importantly,
Ir1-DMSO
exhibited
good
sensitivity,
high
selectivity,
anti-interference
capability
L-His/Ha/His-containing
proteins,
advantageous
due
fabrication
low
technical
demands.
This
was
attributed
reaction
with
imidazole
groups
Furthermore,
show
utility
PL
imaging
agent
cultures
E.
coli
S.
aureus.
Considering
diversity
composition
structural
flexibility,
it
extended
other
solvents
Ir-ligand
complexes
analyses
based
on
specific
molecular
recognition
sensing
platforms.
Язык: Английский