CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

Angewandte Chemie International Edition, Год журнала: 2012, Номер 51(36), С. 8960 - 9009

Опубликована: Авг. 6, 2012

Abstract The direct functionalization of CH bonds in organic compounds has recently emerged as a powerful and ideal method for the formation carbon–carbon carbon–heteroatom bonds. This Review provides an overview bond strategies rapid synthesis biologically active such natural products pharmaceutical targets.

Язык: Английский

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Cu and Cu-Based Nanoparticles: Synthesis and Applications in Catalysis

Chemical Reviews, Год журнала: 2016, Номер 116(6), С. 3722 - 3811

Опубликована: Март 3, 2016

The applications of copper (Cu) and Cu-based nanoparticles, which are based on the earth-abundant inexpensive metal, have generated a great deal interest in recent years, especially field catalysis. possible modification chemical physical properties these nanoparticles using different synthetic strategies conditions and/or via postsynthetic treatments has been largely responsible for rapid growth nanomaterials their In addition, design development novel support multimetallic systems (e.g., alloys, etc.) also made significant contributions to field. this comprehensive review, we report approaches Cu (metallic copper, oxides, hybrid nanostructures) immobilized into or supported various materials (SiO2, magnetic materials, etc.), along with synthesis part discusses numerous preparative protocols whereas application sections describe utility as catalysts, including electrocatalysis, photocatalysis, gas-phase We believe critical appraisal will provide necessary background information further advance nanostructured

Язык: Английский

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Recent advances in the transition metal-catalyzed twofold oxidative C–H bond activation strategy for C–C and C–N bond formation

Chemical Society Reviews, Год журнала: 2011, Номер 40(10), С. 5068 - 5068

Опубликована: Янв. 1, 2011

The direct functionalization of heterocyclic compounds has emerged as one the most important topics in field metal-catalyzed C–H bond activation due to fact that products are an synthetic motif organic synthesis, pharmaceutical industry, and materials science. This critical review covers recent progresses on regioselective dehydrogenative coupling reaction heteroarenes, including arylation, olefination, alkynylation, amination/amidation mainly utilizing transition metal catalysts (113 references).

Язык: Английский

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C–H bond activation enables the rapid construction and late-stage diversification of functional molecules

Nature Chemistry, Год журнала: 2013, Номер 5(5), С. 369 - 375

Опубликована: Апрель 23, 2013

Язык: Английский

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C–C, C–O and C–N bond formation via rhodium(iii)-catalyzed oxidative C–H activation

Chemical Society Reviews, Год журнала: 2012, Номер 41(9), С. 3651 - 3651

Опубликована: Янв. 1, 2012

Rhodium(III)-catalyzed direct functionalization of C-H bonds under oxidative conditions leading to C-C, C-N, and C-O bond formation is reviewed. Various arene substrates bearing nitrogen oxygen directing groups are covered in their coupling with unsaturated partners such as alkenes alkynes. The facile construction C-E (E = C, N, S, or O) makes Rh(III) catalysis an attractive step-economic approach value-added molecules from readily available starting materials. Comparisons contrasts between rhodium(III) palladium(II)-catalyzed made. remarkable diversity structures accessible demonstrated various recent examples, a proposed mechanism for each transformation being briefly summarized (critical review, 138 references).

Язык: Английский

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3d Transition Metals for C–H Activation

Chemical Reviews, Год журнала: 2018, Номер 119(4), С. 2192 - 2452

Опубликована: Ноя. 27, 2018

C–H activation has surfaced as an increasingly powerful tool for molecular sciences, with notable applications to material crop protection, drug discovery, and pharmaceutical industries, among others. Despite major advances, the vast majority of these functionalizations required precious 4d or 5d transition metal catalysts. Given cost-effective sustainable nature earth-abundant first row metals, development less toxic, inexpensive 3d catalysts gained considerable recent momentum a significantly more environmentally-benign economically-attractive alternative. Herein, we provide comprehensive overview on until summer 2018.

Язык: Английский

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Palladium-Catalyzed Transformations of Alkyl C–H Bonds

Chemical Reviews, Год журнала: 2016, Номер 117(13), С. 8754 - 8786

Опубликована: Дек. 2, 2016

This Review summarizes the advancements in Pd-catalyzed C(sp3)-H activation via various redox manifolds, including Pd(0)/Pd(II), Pd(II)/Pd(IV), and Pd(II)/Pd(0). While few examples have been reported of alkane C-H bonds, many activation/C-C C-heteroatom bond forming reactions developed by use directing group strategies to control regioselectivity build structural patterns for synthetic chemistry. A number mono- bidentate ligands also proven be effective accelerating directed weakly coordinating auxiliaries, which provides great opportunities reactivity selectivity (including enantioselectivity) functionalization reactions.

Язык: Английский

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The Cross‐Dehydrogenative Coupling of CH Bonds: A Versatile Strategy for CC Bond Formations

Angewandte Chemie International Edition, Год журнала: 2013, Номер 53(1), С. 74 - 100

Опубликована: Ноя. 8, 2013

Abstract Over the last decade, substantial research has led to introduction of an impressive number efficient procedures which allow selective construction CC bonds by directly connecting two different CH under oxidative conditions. Common these methodologies is generation reactive intermediates in situ activation both bonds. This strategy was introduced group Li as cross‐dehydrogenative coupling (CDC) and discloses waste‐minimized synthetic alternatives classic rely on use prefunctionalized starting materials. Review highlights recent progress field C C formations provides a comprehensive overview existing employed methodologies.

Язык: Английский

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Mild metal-catalyzed C–H activation: examples and concepts

Chemical Society Reviews, Год журнала: 2016, Номер 45(10), С. 2900 - 2936

Опубликована: Янв. 1, 2016

C–H Activation reactions that proceed under mild conditions are more attractive for applications in complex molecule synthesis. Mild transformations reported since 2011 reviewed and the different concepts strategies have enabled their mildness discussed.

Язык: Английский

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Beyond Directing Groups: Transition‐Metal‐Catalyzed CH Activation of Simple Arenes

Angewandte Chemie International Edition, Год журнала: 2012, Номер 51(41), С. 10236 - 10254

Опубликована: Сен. 20, 2012

The use of coordinating moieties as directing groups for the functionalization aromatic C-H bonds has become an established tool to enhance reactivity and induce regioselectivity. Nevertheless, with regard synthetic applicability activation, there is a growing interest in transformations which group can be fully abandoned, thus allowing direct simple benzene derivatives. However, this approach requires disclosure new strategies achieve control selectivity. In review, recent advances emerging field non-chelate-assisted activation are discussed, highlighting some most intriguing inspiring examples induction

Язык: Английский

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