Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Chemical Reviews, Год журнала: 2021, Номер 121(21), С. 13454 - 13619

Опубликована: Сен. 28, 2021

This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is photochemical-based treatment approach that involves the use of light combined with light-activated chemical, referred as PS. Attractively, PDT one alternatives conventional cancer due its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although concept photosensitizer-based photodynamic has been widely adopted clinical trials bioimaging, until now, our surprise, there no relevant article on rational designs organic PDT. Furthermore, most published articles focused nanomaterials nanotechnology based traditional PSs. Therefore, this aimed at reporting recent strategies develop innovative enhanced therapy, each example described detail instead providing only general overview, typically done previous reviews PDT, provide intuitive, vivid, specific insights readers.

Язык: Английский

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Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

Chemical Society Reviews, Год журнала: 2021, Номер 50(6), С. 4185 - 4219

Опубликована: Янв. 1, 2021

Molecular design directions for overcoming the photodynamic therapy challenges.

Язык: Английский

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Emerging combination strategies with phototherapy in cancer nanomedicine

Chemical Society Reviews, Год журнала: 2020, Номер 49(22), С. 8065 - 8087

Опубликована: Янв. 1, 2020

Based on the challenges in single-mode phototherapy, this review summarizes significant research progress combinatorial strategies with phototherapy.

Язык: Английский

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Conquering the Hypoxia Limitation for Photodynamic Therapy

Advanced Materials, Год журнала: 2021, Номер 33(48)

Опубликована: Сен. 27, 2021

Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However, due the hypoxic nature characteristic of many solid tumors, PDT is frequently limited therapeutic effect. Moreover, consumption O2 during may further aggravate tumor condition, which promotes proliferation, metastasis, invasion resulting poor prognosis treatment. Therefore, numerous efforts have been made increase content with goal enhancing efficacy. Herein, these strategies developed past decade are comprehensively reviewed alleviate hypoxia, including 1) delivering exogenous directly, 2) generating situ, 3) reducing cellular by inhibiting respiration, 4) regulating TME, (e.g., normalizing vasculature or disrupting extracellular matrix), 5) hypoxia-inducible factor 1 (HIF-1) signaling pathway relieve hypoxia. Additionally, -independent Type-I also discussed as an alternative strategy. By reviewing progress, it hoped that this review will provide innovative perspectives new nanomaterials designed combat hypoxia avoid associated limitation PDT.

Язык: Английский

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Type I Photosensitizers Revitalizing Photodynamic Oncotherapy

Small, Год журнала: 2021, Номер 17(31)

Опубликована: Май 26, 2021

Photodynamic therapy (PDT) has shown great potential for tumor treatment with merits of non-invasiveness, high selectivity, and minimal side effects. However, conventional type II PDT relying on 1 O2 presents poor therapeutic efficacy hypoxic tumors due to the oxygen-dependent manner. Alternatively, emerging researches have demonstrated that I exhibits superiority over in owing its diminished oxygen-dependence. In this review, state-of-the-art studies concerning recent progress photosensitizers are scrutinized, emphasizing strategies construct highly effective photosensitizers. As foundation, basic principles presented, up-to-date summarized classified based their attributes. Then, a literature review representative (including nanomaterials small molecules) is presented impetus delineate novel designs, action mechanisms, as well anticancer applications. Finally, remaining challenges development directions outlined, highlighting key scientific issues toward clinical translations.

Язык: Английский

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BODIPY‐Based Photodynamic Agents for Exclusively Generating Superoxide Radical over Singlet Oxygen

Angewandte Chemie International Edition, Год журнала: 2021, Номер 60(36), С. 19912 - 19920

Опубликована: Июль 6, 2021

Abstract Developing Type‐I photosensitizers is considered as an efficient approach to overcome the deficiency of traditional photodynamic therapy (PDT) for hypoxic tumors. However, it remains a challenge design generating reactive oxygen species by process. Herein, we report series α,β‐linked BODIPY dimers and trimer that exclusively generate superoxide radical (O 2 −. ) process upon light irradiation. The triplet formation originates from effective excited‐state relaxation initially populated singlet (S 1 (T states via intermediate state. low reduction potential ultralong lifetime T state facilitate generation O inter‐molecular charge transfer molecular oxygen. energy gap ‐S 0 smaller than between 3 thereby precluding Type‐II exhibits superior PDT performance under environment.

Язык: Английский

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Photodynamic therapy for hypoxic tumors: Advances and perspectives

Coordination Chemistry Reviews, Год журнала: 2021, Номер 438, С. 213888 - 213888

Опубликована: Март 16, 2021

Язык: Английский

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Supramolecular Photosensitizer Enables Oxygen-Independent Generation of Hydroxyl Radicals for Photodynamic Therapy

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(7), С. 4081 - 4087

Опубликована: Фев. 13, 2023

The highly oxygen-dependent nature of photodynamic therapy (PDT) limits its therapeutic efficacy against hypoxic solid tumors in clinics, which is an urgent problem to be solved. Herein, we develop oxygen-independent supramolecular agent that produces hydroxyl radical (•OH) by oxidizing water the presence intracellularly abundant pyruvic acid under oxygen-free conditions. A fluorene-substituted BODIPY was designed as electron donor and coassembled with perylene diimide acceptor form quadruple hydrogen-bonded agent. Detailed mechanism studies reveal intermolecular transfer charge separation upon light irradiation result efficient generation ion pairs. Under conditions, cationic radicals directly oxidize generate cytotoxic •OH, anionic electrons acid, realizing catalytic cycle. Thus, this exhibited superb photocytotoxicity even severe environments excellent vivo antitumor on HeLa-bearing mouse models. This work provides a strategy for constructing agents, opens up avenue effective PDT tumors.

Язык: Английский

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Photocatalytic Superoxide Radical Generator that Induces Pyroptosis in Cancer Cells

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(25), С. 11326 - 11337

Опубликована: Июнь 16, 2022

Pyroptosis, a newly characterized form of immunogenic cell death, is attracting increasing attention as promising approach to cancer immunotherapy. However, biocompatible strategies activate pyroptosis remain rare. Here, we show that photocatalytic superoxide radical (O2-•) generator, NI-TA, triggers in cells. NI-TA was designed take advantage an intramolecular triplet-ground state splitting energy modulation approach. Detailed studies revealed the triggered by under conditions photoexcitation proceeds through caspase-3/gasdermin E (GSDME) pathway rather than via canonical processes involving caspase-1/gasdermin-D (GSDMD). found function partial-O2-recycling mode action and trigger provide for effective ablation even hypoxia (≤2% O2). In case T47D 3D multicellular spheroids, good antitumor efficiency stemness inhibition are achieved. This work highlights how chemistry may be leveraged develop pyroptosis-inducing agents.

Язык: Английский

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Nanostructured Phthalocyanine Assemblies with Efficient Synergistic Effect of Type I Photoreaction and Photothermal Action to Overcome Tumor Hypoxia in Photodynamic Therapy

Journal of the American Chemical Society, Год журнала: 2021, Номер 143(34), С. 13980 - 13989

Опубликована: Авг. 24, 2021

Most photodynamic therapy (PDT) paradigms work through the highly O2-dependent type II photoreaction to generate singlet oxygen (1O2). The hypoxic microenvironment of solid tumors severely hampers therapeutic outcomes. Here, we present a novel design that could transfer photophysical and photochemical properties traditional phthalocyanine-based photosensitizers from efficient I vibrational relaxation-induced photothermal conversion. These features enable obtained nanostructured phthalocyanine assemblies (e.g., NanoPcAF) display excellent phototherapies under both normoxic conditions. Moreover, NanoPcAF has high level accumulation in tumor tissues after intravenous injection, 94% growth is inhibited preclinical model at dose 0.8 nmol g–1 light 300 J cm–2.

Язык: Английский

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