Nanozyme Catalytic Turnover and Self-Limited Reactions

ACS Nano, Год журнала: 2021, Номер 15(10), С. 15645 - 15655

Опубликована: Окт. 8, 2021

Enzymes have catalytic turnovers. The field of nanozyme endeavors to engineer nanomaterials as enzyme mimics. However, a discrepancy in the definition "nanozyme concentration" has led an unrealistic calculation To date, most reported works considered either atomic concentration or nanoparticle (NP) concentration. These assumptions can lead significant under- overestimation activity nanozymes. In this article, we review some classic nanozymes including Fe3O4, CeO2, and gold nanoparticles (AuNPs) with focus on activities. We argue that only surface atoms should be active sites, then turnover numbers rates were recalculated based atoms. According calculations, peroxidase Fe3O4 NPs is validated. AuNPs are self-limited when performing glucose-oxidase like activity, but they also true catalysts. For CeO2 NPs, behavior observed for both oxidase- phosphatase-like activities due adsorption reaction products. Moreover, single-atom discussed. Finally, few suggestions future research proposed.

Язык: Английский

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Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy

Theranostics, Год журнала: 2022, Номер 13(1), С. 295 - 323

Опубликована: Дек. 19, 2022

Cancer remains a severe threat to human health. To date, although various therapeutic methods, including radiotherapy (RT), chemotherapy, chemodynamic therapy (CDT), phototherapy, starvation therapy, and immunotherapy, have entered new stage of rapid progress in cancer theranostics, their limited effect significant side effects need be considered carefully. With the development nanotechnology, marriage nanomaterials methods provides practical possibility improve deficiencies therapy. Notably, metal-organic frameworks (MOFs) composed ions/clusters bridging ligands through coordination bonds been widely applied deal with drawbacks different such as effects, low stability, poor efficacy, owing controllable morphologies, tailorable diameters, diverse compositions, tunable porosities, high specific surface areas, facile functionalization, good biocompatibility. This review summarizes recent advanced developments achievements multifunctional MOF-based nanoplatforms for single RT, CDT, phototherapy (photodynamic photothermal therapy), combination methods. Moreover, prospects challenges used tumor are also discussed.

Язык: Английский

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Recent advances of redox-responsive nanoplatforms for tumor theranostics

Journal of Controlled Release, Год журнала: 2021, Номер 332, С. 269 - 284

Опубликована: Март 1, 2021

Язык: Английский

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Recent advances in porphyrin-based MOFs for cancer therapy and diagnosis therapy

Coordination Chemistry Reviews, Год журнала: 2021, Номер 439, С. 213945 - 213945

Опубликована: Апрель 24, 2021

Язык: Английский

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Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Advanced Functional Materials, Год журнала: 2021, Номер 31(50)

Опубликована: Сен. 8, 2021

Abstract Multiple enzyme‐driven biological catalytic cascades occur in living organisms, guiding highly efficient and selective transformations of substrates. Inspired by the merits these cascade systems, enormous efforts have been devoted to developing novel systems mimic reactions over past few years. Nanozymes, a class enzyme mimics, are nanomaterials with enzyme‐like activity. The emergence development nanozymes has significantly advanced biomimetic nanoreactors. Currently, nanoreactors driven widely used exhibit many advantages such as superior efficiency high stability, resulting significant advancements biosensing biomedical applications. latest advances understanding mechanism nanozyme‐engineered their progressive applications for comprehensively covered here. First, nanozyme enzyme/nanozyme‐engineered categorized according properties. Then, applications, including cancer therapy, antibacterial activity, antioxidation, hyperuricemia therapy covered. conclusion describes most important challenges opportunities remaining this exciting area research.

Язык: Английский

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Recent development of metal-organic framework nanocomposites for biomedical applications

Biomaterials, Год журнала: 2021, Номер 281, С. 121322 - 121322

Опубликована: Дек. 15, 2021

Язык: Английский

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Heterostructured hybrids of metal–organic frameworks (MOFs) and covalent–organic frameworks (COFs)

Journal of Materials Chemistry A, Год журнала: 2021, Номер 10(2), С. 475 - 507

Опубликована: Дек. 15, 2021

MOF/COF-based hybrids show the properties of precisely tunable compositions and structures, provide a broad range potential applications in gas sorption separation, catalysis, energy transfer, biomedicine, etc.

Язык: Английский

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Toward the Design and Construction of Supramolecular Functional Molecular Materials Based on Metal–Metal Interactions

Journal of the American Chemical Society, Год журнала: 2022, Номер 144(50), С. 22805 - 22825

Опубликована: Дек. 9, 2022

Supramolecular functional materials represent an emerging class of that have been governed by the supramolecular chemistry self-assembled molecules. Such high-order molecular hierarchies stabilized various kinds noncovalent intermolecular forces including hydrogen bonding, electrostatic, donor–acceptor, π–π stacking interactions, and dispersion forces. Recently, metal–metal interactions also emerged as unconventional type interaction is unique in metal complex system for construction metal-based materials. These further imparted with rich spectroscopic functionalities. However, systematic control these hierarchical architectures through remains challenging. In this Perspective, we aim to stimulate research direction field utilization such intriguing directional one driving forces, highlighting roles significance ultimately facilitating a controlled rational design synthesis metallosupramolecular properties huge potential applications.

Язык: Английский

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Upconverted/downshifted NaLnF4 and metal-organic framework heterostructures boosting NIR-II imaging-guided photodynamic immunotherapy toward tumors

Nano Today, Год журнала: 2022, Номер 43, С. 101439 - 101439

Опубликована: Март 3, 2022

Язык: Английский

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Bifunctional Cascading Nanozymes Based on Carbon Dots Promotes Photodynamic Therapy by Regulating Hypoxia and Glycolysis

ACS Nano, Год журнала: 2023, Номер 17(17), С. 16715 - 16730

Опубликована: Авг. 18, 2023

Photodynamic therapy (PDT) still faces great challenges with suitable photosensitizers, oxygen supply, and reactive species (ROS) accumulation, especially in the tumor microenvironment, feathering hypoxia, high glucose metabolism. Herein, a carbon dots (CDs)-based bifunctional nanosystem (MnZ@Au), acting as photosensitizer nanozyme cascading oxidase (GOx)- catalase (CAT)-like reactivity, was developed for improving hypoxia regulating metabolism to enhance PDT. The MnZ@Au constructed using Mn-doped CDs (Mn-CDs) core zeolitic imidazolate framework-8 (ZIF-8) shell form hybrid (MnZ), followed by anchoring ultrasmall Au nanoparticles (AuNPs) onto surface of MnZ through ion exchange situ reduction methods. catalyzed consumption generation GOx- CAT-like reactions, which further enhanced its own photothermal properties. In vitro vivo studies also confirmed that greatly improved penetration, promoted ROS PDT efficacy, leading efficient growth inhibition breast model. Besides, enabled photoacoustic (PA) imaging provide mapping Mn-CDs distribution saturation, showing real-time catalytic process vivo. 18F-Fluorodeoxyglucose positron emission tomography (18F-FDG PET) validated decreased uptake tumors treated MnZ@Au. Therefore, integrated design provided promising strategy utilize regulate promote PDT, finally prevent deterioration.

Язык: Английский

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