Opportunities for Persistent Luminescent Nanoparticles in Luminescence Imaging of Biological Systems and Photodynamic Therapy

Nanomaterials, Год журнала: 2020, Номер 10(10), С. 2015 - 2015

Опубликована: Окт. 13, 2020

The use of luminescence in biological systems allows us to diagnose diseases and understand cellular processes. Persistent luminescent materials have emerged as an attractive system for application imaging systems; the afterglow emission grants background-free imaging, there is no need continuous excitation avoid tissue cell damage due light exposure, they also circumvent depth penetration issue caused by UV-Vis. This review aims provide a background systems, persistent luminescence, synthetic methods obtaining materials, discuss selected examples recent literature on applications photodynamic therapy. Finally, challenges future directions, pointing development compounds capable executing multiple functions regions where tissues cells low absorption, will be discussed.

Язык: Английский

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Recent progress in metal-based molecular probes for optical bioimaging and biosensing

Current Opinion in Chemical Biology, Год журнала: 2021, Номер 66, С. 102097 - 102097

Опубликована: Ноя. 11, 2021

Язык: Английский

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Current Development of Lanthanide Complexes for Biomedical Applications

Chemistry - An Asian Journal, Год журнала: 2024, Номер 19(7)

Опубликована: Фев. 13, 2024

Luminescent molecule-based bioimaging system is widely used for precise localization and distinction of cancer/tumor cells. lanthanide (Ln(III)) complexes offer long-lived (sub-millisecond time scale) sharp (FWHM <10 nm) emission, arising from the forbidden 4f-4f electronic transitions. Ln(III) complex-based has emerged as a promising option both in vitro vivo visualizations. In this mini-review, historical development recent significant progress luminescent probes bioapplications are introduced. The studies mainly focused on three points: (i) structural modifications macrocyclic small ligands, (ii) acquirement high resolution luminescence images cells (iii) constructions ratiometric biosensors. Furthermore, our study explained new Cancer GPS (cancer grade probing determining tumor through photophysical property analyses intracellular Eu(III) complex.

Язык: Английский

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Multiplex and In Vivo Optical Imaging of Discrete Luminescent Lanthanide Complexes Enabled by In Situ Cherenkov Radiation Mediated Energy Transfer

Journal of the American Chemical Society, Год журнала: 2021, Номер 143(24), С. 9206 - 9214

Опубликована: Июнь 11, 2021

Recently, we pioneered the application of Cherenkov radiation (CR) radionuclides for in situ excitation discrete Eu(III) and Tb(III) complexes. CR is produced by isotopes decaying under emission charged particles dielectric media exhibits a maximum intensity below 400 nm. We have demonstrated that luminescent lanthanide antenna complexes are ideal acceptors radiation-mediated energy transfer (CRET). Here, develop assess peptide-functionalized conjunction with CRET positron emissive radioisotope 18F simultaneous, multiplexed imaging vivo optical imaging. This work demonstrates, first time, detection luminescence complex feasible. Our results open possibilities to be used as diagnostic, tools intrasurgical guidance tumor resection.

Язык: Английский

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Bioorthogonal Lanthanide Molecular Probes for Near‐Infrared Fluorescence and Mass Spectrometry Imaging

Angewandte Chemie International Edition, Год журнала: 2022, Номер 61(43)

Опубликована: Авг. 22, 2022

Abstract We report here the development of clickable and highly near‐infrared (NIR) fluorescent lanthanide (Ln) complexes for bioorthogonal labeling biomolecules. These azide‐ or alkyne‐functionalized Ln are hydrophilic fluorogenic, exhibiting a strong increase NIR fluorescence upon conjugation with Metabolic biomolecules azide alkyne, followed by click complexes, enables (NIRF) imaging DNA, RNA, proteins, glycans in cells. Furthermore, multicolor is performed combining click‐labeling immunostaining. In addition, compatible click‐expansion microscopy (click‐ExM), which high‐resolution NIRF cellular glycoproteins. Finally, can be used time‐of‐flight secondary‐ion mass spectrometry (ToF‐SIMS) imaging, thus achieving first example dual‐modal SIMS microscopies.

Язык: Английский

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Circularly polarized activity from two photon excitable europium and samarium chiral bioprobes

Journal of Materials Chemistry C, Год журнала: 2023, Номер 11(12), С. 4188 - 4202

Опубликована: Янв. 1, 2023

Circularly polarized luminescence activity from new cationic water soluble Sm( iii ) and Eu( complexes is triggered by one- two-photon absorption processes. The complex shown to be an efficient NIR-to-RED probe in cellulo .

Язык: Английский

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Chiral Pyclen-Based Heptadentate Chelates as Highly Stable MRI Contrast Agents

Inorganic Chemistry, Год журнала: 2024, Номер 63(18), С. 8462 - 8475

Опубликована: Апрель 20, 2024

In recent years, pyclen-based complexes have attracted a great deal of interest as magnetic resonance imaging (MRI) contrast agents (CAs) and luminescent materials, well radiopharmaceuticals. Remarkably, gadopiclenol, Gd(III) bishydrated complex featuring heptadentate ligand, received approval novel agent for clinical MRI application in 2022. To maximize stability efficiency, two chiral chelators their were developed this study. Gd-X-PCTA-2 showed significant enhancements both thermodynamic kinetic stabilities compared to those the achiral parent derivative Gd-PCTA. 1H NMRD profiles reveal that gadolinium (Gd-X-PCTA-1 Gd-X-PCTA-2) higher relaxivity than Gd-PCTA, while variable-temperature 17O NMR studies show inner-sphere water molecules distinct residence times τMa τMb. Furthermore, vivo demonstrates enhances signal heart kidneys mice, Gd exhibit ability distinguish between tumors normal tissues 4T1 mouse model more efficiently gadobutrol. Biodistribution Gd-PCTA are primarily cleared by renal pathway, with 24 h residues liver kidney being lower

Язык: Английский

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Mn²⁺ Complexes with Pyclen-Based Derivatives as Contrast Agents for Magnetic Resonance Imaging: Synthesis and Relaxometry Characterization

Inorganic Chemistry, Год журнала: 2021, Номер 60(6), С. 3604 - 3619

Опубликована: Фев. 24, 2021

Magnetic resonance imaging (MRI) has a leading place in medicine as an tool of high resolution for anatomical studies and diagnosis diseases, particular soft tissues that cannot be accessible by other modalities. Many research works are thus focused on improving the images obtained with MRI. This technique indeed poor sensitivity, which can compensated using contrast agent (CA). Today, clinically approved CAs market solely based gadolinium complexes may induce nephrogenic systemic fibrosis patients kidney failure, whereas more recent healthy rats also showed Gd retention brain. Consequently, researchers try to elaborate types safer MRI like manganese-based complexes. In this context, synthesis Mn2+ four 12-membered pyridine-containing macrocyclic ligands pyclen core was accomplished described herein. Then, properties these Mn(II) were studied two relaxometric methods, 17O NMR spectroscopy 1H dispersion profiles. The time residence (τM) number water molecules (q) present inner sphere coordination determined experiments. efficacy pyclen-based evaluated proton relaxometry at magnetic field intensity 1.41 T near those most medical scanners (1.5 T). Both nuclear relaxation profiles indicated hexadentate prepared herein left one vacant site accommodate molecule, rapidly exchanging, around 6 ns. Furthermore, it been shown presence additional amide bond formed when paramagnetic complex is conjugated molecule interest does not alter Mn, remains monohydrated. These exhibit r1 relaxivities, large enough used clinical (1.7–3.4 mM–1·s–1, 37 °C).

Язык: Английский

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Eu(iii), Tb(iii) activated/co-activated K₂NaAlF₆ host array: simultaneous approach for improving photovoltaic efficiency and tricolour emission

New Journal of Chemistry, Год журнала: 2021, Номер 46(1), С. 334 - 344

Опубликована: Ноя. 22, 2021

Rare earth-activated fluoride phosphors have generated attention in recent years the field of solid-state lighting and solar cell efficiency enhancement.

Язык: Английский

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Excited-Multimer Mediated Supramolecular Upconversion on Multicomponent Lanthanide-Organic Assemblies

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(42), С. 23121 - 23130

Опубликована: Окт. 16, 2023

Upconversion (UC) is a fascinating anti-Stokes-like optical process with promising applications in diverse fields. However, known UC mechanisms are mainly based on direct energy transfer between metal ions, which constrains the designability and tunability of structures properties. Here, we synthesize two types Ln8L12-type (Ln for lanthanide ion; L organic ligand L1 or L2R/S) lanthanide-organic complexes assembly induced excited-multimer states. The Yb8(L2R/S)12 exhibits upconverted multimer green fluorescence under 980 nm excitation through cooperative sensitization process. Furthermore, red emission from Eu3+ heterometallic (Yb/Eu)8L12 assemblies also realized via mediated relay. Our findings demonstrate new strategy designing materials, crucial exploiting photofunctions multicomponent complexes.

Язык: Английский

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