The Chemical Record,
Год журнала:
2023,
Номер
23(9)
Опубликована: Апрель 26, 2023
Abstract
Carbamoyl
fluorides,
fluoroformates,
and
their
analogues
are
a
class
of
important
compounds
have
been
evidenced
as
versatile
building
blocks
for
the
preparation
useful
molecules
in
organic
chemistry.
While
major
achievements
were
made
synthesis
carbamoyl
last
half
20
th
century,
an
increasing
number
reports
focused
on
using
O/S/Se=CF
2
species
or
equivalents
fluorocarbonylation
reagents
direct
construction
these
from
parent
heteroatom‐nucleophiles
recent
years.
This
review
mainly
summarizes
advances
typical
application
by
halide
exchanges
reactions
since
1980.
Chinese Journal of Chemistry,
Год журнала:
2022,
Номер
41(3), С. 294 - 300
Опубликована: Окт. 17, 2022
Comprehensive
Summary
NiH‐catalyzed
multicomponent
reductive
hydrofunctionalization
of
alkenes
is
an
attractive
but
poorly
explored
approach
to
rapidly
increasing
molecular
complexity.
In
this
process,
the
selective
generation
desired
product
can
be
challenging.
Herein,
we
report
that
a
highly
chemo‐,
regio‐
and
enantioselective
hydrocarbonylation
has
been
achieved
using
chloroformate
ester
as
source
CO.
A
wide
range
structurally
diverse
α‐hydroxy
ketones,
privileged
structural
elements
in
bioactive
molecules
useful
building
blocks,
were
obtained
from
such
reactions
with
high
enantiomeric
purity.
Organic Letters,
Год журнала:
2021,
Номер
23(16), С. 6407 - 6411
Опубликована: Авг. 4, 2021
Herein
we
report
a
nickel-catalyzed
asymmetric
reductive
dicarbamoylation
of
alkenes,
in
which
tethered
carbamoyl
chlorides
and
isocyanates
serve
as
distinct
electrophilic
carbamoylating
agents,
providing
new
access
to
chiral
oxindoles
bearing
an
amide-substituted
quaternary
stereogenic
center.
The Journal of Organic Chemistry,
Год журнала:
2022,
Номер
87(17), С. 11457 - 11468
Опубликована: Авг. 16, 2022
We
report
a
method
for
the
synthesis
of
carbamoyl
fluorides
from
secondary
amines
using
bench-stable,
inexpensive,
and
readily
accessible
starting
materials
that,
when
combined,
yield
surrogate
toxic
difluorophosgene
(COF2)
gas.
In
contrast
to
state-of-the-art
methods
fluorides,
our
protocol
does
not
require
use
pre-functionalized
substrates,
preparation
light-,
temperature-,
and/or
moisture-sensitive
chemicals,
or
application
explosive
fluorinating
reagents.
The Chemical Record,
Год журнала:
2023,
Номер
23(9)
Опубликована: Апрель 26, 2023
Abstract
Carbamoyl
fluorides,
fluoroformates,
and
their
analogues
are
a
class
of
important
compounds
have
been
evidenced
as
versatile
building
blocks
for
the
preparation
useful
molecules
in
organic
chemistry.
While
major
achievements
were
made
synthesis
carbamoyl
last
half
20
th
century,
an
increasing
number
reports
focused
on
using
O/S/Se=CF
2
species
or
equivalents
fluorocarbonylation
reagents
direct
construction
these
from
parent
heteroatom‐nucleophiles
recent
years.
This
review
mainly
summarizes
advances
typical
application
by
halide
exchanges
reactions
since
1980.
