Analytical Chemistry,
Год журнала:
2021,
Номер
93(48), С. 16105 - 16112
Опубликована: Ноя. 19, 2021
Cancer
is
a
serious
threat
to
human
health,
and
there
an
urgent
need
develop
new
treatment
methods
overcome
it.
Organelle
targeting
therapy,
as
highly
effective
less
toxic
side
effect
strategy,
has
great
research
significance
development
prospects.
Being
essential
organelle,
the
Golgi
apparatus
plays
particularly
major
role
in
growth
of
cancer
cells.
Acting
indispensable
expressed
antioxidant
cells,
glutathione
(GSH)
also
contributes
greatly
during
oxidative
stress.
Therefore,
it
counts
for
much
track
changes
GSH
concentration
monitoring
occurrence
tumor
exploring
Golgi-targeted
therapy
extremely
important
cancer.
In
this
work,
we
designed
synthesized
simple
Golgi-targeting
fluorescent
probe
GT-GSH
accurately
detecting
GSH.
The
reacting
with
decomposes
substances
Golgi,
thereby
killing
At
same
time,
ratiometric
can
detect
stress
high
sensitivity
selectivity
living
such
GSH-responsive
gives
method
accurate
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(19)
Опубликована: Март 3, 2023
NAD(P)H
is
crucial
for
biosynthetic
reactions
and
antioxidant
functions.
However,
the
current
probes
developed
detecting
in
vivo
require
intratumoral
injection,
which
limited
their
application
animal
imaging.
To
address
this
issue,
we
have
a
liposoluble
cationic
probe,
KC8,
exhibits
excellent
tumor-targeting
ability
near-infrared
(NIR)
fluorescence
after
reaction
with
NAD(P)H.
By
using
it
was
demonstrated
first
time
that
level
of
mitochondria
living
colorectal
cancer
(CRC)
cells
highly
related
to
abnormality
p53.
Furthermore,
KC8
successfully
used
differentiate
not
only
between
tumor
normal
tissue
but
also
tumors
p53
when
administered
intravenously.
Finally,
evaluated
heterogeneity
through
two
fluorescent
channels
treating
5-Fu.
This
study
provides
new
tool
real-time
monitoring
CRC
cells.
Analytical Chemistry,
Год журнала:
2021,
Номер
93(48), С. 16105 - 16112
Опубликована: Ноя. 19, 2021
Cancer
is
a
serious
threat
to
human
health,
and
there
an
urgent
need
develop
new
treatment
methods
overcome
it.
Organelle
targeting
therapy,
as
highly
effective
less
toxic
side
effect
strategy,
has
great
research
significance
development
prospects.
Being
essential
organelle,
the
Golgi
apparatus
plays
particularly
major
role
in
growth
of
cancer
cells.
Acting
indispensable
expressed
antioxidant
cells,
glutathione
(GSH)
also
contributes
greatly
during
oxidative
stress.
Therefore,
it
counts
for
much
track
changes
GSH
concentration
monitoring
occurrence
tumor
exploring
Golgi-targeted
therapy
extremely
important
cancer.
In
this
work,
we
designed
synthesized
simple
Golgi-targeting
fluorescent
probe
GT-GSH
accurately
detecting
GSH.
The
reacting
with
decomposes
substances
Golgi,
thereby
killing
At
same
time,
ratiometric
can
detect
stress
high
sensitivity
selectivity
living
such
GSH-responsive
gives
method
accurate
