Pharmaceutics,
Год журнала:
2023,
Номер
15(10), С. 2406 - 2406
Опубликована: Сен. 30, 2023
The
main
concept
of
radiosensitization
is
making
the
tumor
tissue
more
responsive
to
ionizing
radiation,
which
leads
an
increase
in
potency
radiation
therapy
and
allows
for
decreasing
dose
concomitant
side
effects.
Radiosensitization
by
metal
oxide
nanoparticles
widely
discussed,
but
range
mechanisms
studied
not
sufficiently
codified
often
does
reflect
ability
nanocarriers
have
a
specific
impact
on
cells.
This
review
focused
magnetic
iron
while
they
occupied
special
niche
among
prospective
radiosensitizers
due
unique
physicochemical
characteristics
reactivity.
We
collected
data
about
possible
molecular
underlying
radiosensitizing
effects
(IONPs)
approaches
their
therapeutic
efficacy
variable
modifications.
Abstract
Mild
magnetic
hyperthermia
therapy
(MMHT)
holds
great
potential
in
treating
deep‐seated
tumors,
but
its
efficacy
is
impaired
by
the
upregulation
of
heat
shock
proteins
(HSPs)
during
treatment
process.
Herein,
Lac‐FcMOF,
a
lactose
derivative
(Lac‐NH
2
)
modified
paramagnetic
metal‐organic
framework
(FcMOF)
with
property
and
thermal
stability,
has
been
developed
to
enhance
MMHT
therapeutic
efficacy.
In
vitro
studies
showed
that
Lac‐FcMOF
aggravates
two‐way
regulated
redox
dyshomeostasis
(RDH)
via
magnetothermal‐accelerated
ferricenium
ions‐mediated
consumption
glutathione
ferrocene‐catalyzed
generation
∙OH
induce
oxidative
damage
inhibit
protein
70
(HSP70)
synthesis,
thus
significantly
enhancing
anti‐cancer
MMHT.
Aggravated
RDH
promotes
peroxidase
4
inactivation
lipid
peroxidation
promote
ferroptosis,
which
further
synergizes
H22‐tumor‐bearing
mice
treated
under
alternating
field
(AMF)
demonstrated
90.4%
inhibition
tumor
growth.
This
work
therefore
provides
new
strategy
for
simple
construction
agent
enables
efficient
downregulating
HSPs
promoting
ferroptosis
through
aggravation
RDH.
Advanced Materials,
Год журнала:
2023,
Номер
35(20)
Опубликована: Март 3, 2023
Abstract
Apoptosis
and
autophagy
determine
the
fate
of
cancer
cells.
However,
simply
promoting
apoptosis
tumor
cells
is
limited
in
treatment
unresectable
solid
liver
tumors.
Generally,
considered
anti‐apoptotic
“guardian”.
But
pro‐apoptotic
effects
can
be
activated
by
excessive
endoplasmic
reticulum
(ER)
stress.
Here,
amphiphilic
peptide‐modified
glutathione
(GSH)‐gold
nanocluster
aggregates
(AP
1
P
2
‐PEG
NCs)
were
designed
with
enrichment
tumors
prolonged
stress
ER,
which
achieve
mutual
promotion
In
this
study,
orthotopic
subcutaneous
models
show
anti‐tumor
effectiveness
AP
NCs,
a
better
antitumor
effect
than
sorafenib,
biosafety
(Lethal
Dose,
50%
(LD
50
)
827.3
mg
kg
−1
),
wide
therapeutic
window
(non‐toxic
20
times
concentration)
high
stability
(blood
half‐life
4
h).
These
findings
identify
an
effective
strategy
to
develop
gold
low
toxicity,
potency,
selectivity
for
treatment.
Bioactive Materials,
Год журнала:
2023,
Номер
25, С. 73 - 85
Опубликована: Янв. 23, 2023
Osteosarcoma
(OS)
patients
have
a
poor
prognosis
due
to
its
high
degree
of
heterogeneity
and
rate
metastasis.
Magnetic
hyperthermia
therapy
(MHT)
combined
with
immunotherapy
is
an
effective
strategy
treat
solid
metastatic
tumors.
Here,
we
biodegradable
magnesium
(Mg)
macroscale
rods,
which
acted
as
eddy
thermo-magnetic
agent
under
low
external
alternating
magnetic
field,
achieve
radical
cure
for
OS.
The
thermal
effect
(ETE)
the
Mg
rods
(MgR)
showed
outstanding
cytotoxic
effects
enhanced
maturation
dendritic
cells
(DCs),
mild
MHT
induced
immunogenic
cell
death
(ICD)
in
OS
cells.
Combined
immune
checkpoint
blockade
(ICB)
therapy,
obtained
excellent
curative
against
OS,
further
evaluation
demonstrated
that
local
by
MgR
increased
T
infiltration
polarization
M1
macrophages.
Interestingly,
also
promoted
bone
osteogenesis.
Our
work
highlighted
uneven
ETE
mediated
comprehensive
immunologic
activation
tumor
microenvironment
(TME),
would
inspire
application
treatment
Pharmaceutics,
Год журнала:
2023,
Номер
15(10), С. 2406 - 2406
Опубликована: Сен. 30, 2023
The
main
concept
of
radiosensitization
is
making
the
tumor
tissue
more
responsive
to
ionizing
radiation,
which
leads
an
increase
in
potency
radiation
therapy
and
allows
for
decreasing
dose
concomitant
side
effects.
Radiosensitization
by
metal
oxide
nanoparticles
widely
discussed,
but
range
mechanisms
studied
not
sufficiently
codified
often
does
reflect
ability
nanocarriers
have
a
specific
impact
on
cells.
This
review
focused
magnetic
iron
while
they
occupied
special
niche
among
prospective
radiosensitizers
due
unique
physicochemical
characteristics
reactivity.
We
collected
data
about
possible
molecular
underlying
radiosensitizing
effects
(IONPs)
approaches
their
therapeutic
efficacy
variable
modifications.
