Recent Advances in the Enantioselective Radical Reactions DOI Creative Commons
Tomasz Bauer, Yusuf Zaim Hakim, Paulina Morawska

и другие.

Molecules, Год журнала: 2023, Номер 28(17), С. 6252 - 6252

Опубликована: Авг. 25, 2023

The review covers research published since 2017 and is focused on enantioselective synthesis using radical reactions. It describes recent approaches to the asymmetric of chiral molecules based application metal catalysis, dual organocatalysis finally, pure including enzyme catalysis. This focuses synthetic aspects methodology tries show which compounds can be obtained in enantiomerically enriched forms.

Язык: Английский

Chiral oxalamide phosphine (COAP)-Pd-catalyzed enantioselective cascade formal [4 + 1] annulation for enantioenriched 2,3-disubstituted indolines and further DFT study on regio- and stereocontrol DOI

Sheng‐Suo Zhou,

Junhao Shen, Wenkai Liu

и другие.

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(9), С. 2138 - 2146

Опубликована: Янв. 1, 2023

COAP-Pd-catalyzed asymmetric cascade formal [4 + 1] annulation was developed between racemic vinyl benzoxazinones and N -tosylhydrazone sodium salts, affording trans -2,3-disubstituted indolines in good yields with high stereoselectivity.

Язык: Английский

Процитировано

14
Stereoselective gem-Difunctionalization of Diazo Compounds with Vinyl Sulfoxonium Ylides and Thiols via Metalloradical Catalysis DOI

Srashti Bhardwaj,

Dinesh Kumar Gopalakrishnan,

Shalu Deshwal

и другие.

ACS Catalysis, Год журнала: 2024, Номер 14(4), С. 2805 - 2815

Опубликована: Фев. 8, 2024

Multicomponent reactions that involve carbenes with nucleophiles and electrophiles have demonstrated broad applications in synthetic chemistry. However, because of the high reactivity transient carbenes, involving two carbene precursors nucleophile presence a metal catalyst remain unexplored. Herein, three-component stereoselective gem-difunctionalization diazo compounds thiols vinyl sulfoxonium ylide is disclosed via Co(II)-based metalloradical catalysis. The key aspect present strategy to exploit intrinsic difference ylides thiol catalysts. Doyle–Kirmse rearrangement sulfonium involves convergent assembly situ-generated intermediates, such as allyl sulfide α- metalloalkyl radical complex, provide expeditious access tertiary scaffolds. Combined experimental quantum chemical calculations unveil intricate mechanism this reaction. Furthermore, theoretical studies on noncovalent interactions selectivity-determining transition states explain origin experimentally obtained diastereoselectivity.

Язык: Английский

Процитировано

6
Radical differentiation of two ester groups in unsymmetrical diazomalonates for highly asymmetric olefin cyclopropanation DOI Creative Commons
Jingyi Wang, Jingjing Xie, Wan‐Chen Cindy Lee

и другие.

Chem Catalysis, Год журнала: 2021, Номер 2(2), С. 330 - 344

Опубликована: Дек. 29, 2021

Язык: Английский

Процитировано

31
Asymmetric radical cyclopropanation of alkenes DOI
Wan‐Chen Cindy Lee, X. Peter Zhang

Trends in Chemistry, Год журнала: 2022, Номер 4(9), С. 850 - 851

Опубликована: Июль 5, 2022

Язык: Английский

Процитировано

21
Recent Advances in the Enantioselective Radical Reactions DOI Creative Commons
Tomasz Bauer, Yusuf Zaim Hakim, Paulina Morawska

и другие.

Molecules, Год журнала: 2023, Номер 28(17), С. 6252 - 6252

Опубликована: Авг. 25, 2023

The review covers research published since 2017 and is focused on enantioselective synthesis using radical reactions. It describes recent approaches to the asymmetric of chiral molecules based application metal catalysis, dual organocatalysis finally, pure including enzyme catalysis. This focuses synthetic aspects methodology tries show which compounds can be obtained in enantiomerically enriched forms.

Язык: Английский

Процитировано

12