Facile and eco-friendly fabrication of biocompatible hydrogel containing CuS@Ser NPs with mechanical flexibility and photothermal antibacterial activity to promote infected wound healing

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Авг. 10, 2023

Abstract Bacterial infections can significantly impede wound healing and pose a serious threat to the patient’s life. The excessive use of antibiotics combat bacterial has led emergence multi-drug-resistant bacteria. Therefore, there is pressing need for alternative approaches, such as photothermal therapy (PTT), address this issue. In study, first time, CuS NPs with properties were synthesized using sericin biological template, named CuS@Ser NPs. This method simple, green, does not produce toxic harmful by-products. These nanoparticles incorporated into mixture (XK) xanthan gum konjac glucomannan (KGM) obtain XK/CuS composite hydrogel, which could overcome limitations current dressings. hydrogel exhibited excellent mechanical flexibility, response, biocompatibility. It also demonstrated potent antibacterial against both Gram-positive negative bacteria via experiments accelerated in animal models. Additionally, it proved that promoted tissue regeneration by stimulating collagen deposition, angiogenesis, reducing inflammation. summary, presents promising clinical management infected wounds, offering new approach promote healing.

Язык: Английский

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Dual-Modal Apoptosis Assay Enabling Dynamic Visualization of ATP and Reactive Oxygen Species in Living Cells

Analytical Chemistry, Год журнала: 2023, Номер 95(6), С. 3507 - 3515

Опубликована: Фев. 1, 2023

ATP and reactive oxygen species (ROS) are considered significant indicators of cell apoptosis. However, visualizing the interplay between apoptosis-related ROS is challenging. Herein, we developed a metal–organic framework (MOF)-based nanoprobe for an apoptosis assay using duplex imaging cellular ROS. The was fabricated through controlled encapsulation gold nanorods with thin zirconium-based MOF layer, followed by modification ROS-responsive molecules 2-mercaptohydroquinone 6-carboxyfluorescein-labeled aptamer. enables visualization via fluorescence surface-enhanced Raman spectroscopy, respectively, avoiding mutual interference that often occurs in single-mode methods. Moreover, dual-modal effectively showed dynamic cancer cells treated various drugs, revealing their pathways interactions differ from those under normal conditions. This study provides method studying relationship energy metabolism redox homeostasis processes.

Язык: Английский

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Harnessing Hafnium‐Based Nanomaterials for Cancer Diagnosis and Therapy

Small, Год журнала: 2023, Номер 19(32)

Опубликована: Апрель 8, 2023

Abstract With the rapid development of nanotechnology and nanomedicine, there are great interests in employing nanomaterials to improve efficiency disease diagnosis treatment. The clinical translation hafnium oxide (HfO 2 ), commercially namedas NBTXR3, as a new kind nanoradiosensitizer for radiotherapy (RT) cancers has aroused extensive interest researches on Hf‐based biomedical application. In past 20 years, have emerged potential important nanomedicine computed tomography (CT)‐involved bioimaging RT‐associated cancer treatment due their excellent electronic structures intrinsic physiochemical properties. this review, bibliometric analysis method is employed summarize progress synthesis technology various nanomaterials, including HfO , ‐based compounds, Hf‐organic ligand coordination hybrids, such metal‐organic frameworks or nanoscaled polymers. Moreover, current states application CT‐involved contrasts tissue imaging reviewed detail. Importantly, recent advances nanomaterials‐mediated radiosensitization synergistic RT with other mainstream treatments also generalized. Finally, challenges future perspectives view maximize research translational medicine discussed.

Язык: Английский

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Self-generated Schottky barriers in niobium carbide MXene nanocatalysts for theory-oriented sonocatalytic and NIR-II photonic hyperthermia tumor therapy

Nano Today, Год журнала: 2023, Номер 48, С. 101750 - 101750

Опубликована: Янв. 5, 2023

Язык: Английский

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Plasmonic Supramolecular Nanozyme‐Based Bio‐Cockleburs for Synergistic Therapy of Infected Diabetic Wounds

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 23, 2024

Abstract Diabetic wounds are a major devastating complication of diabetes due to hyperglycemia, bacterial invasion, and persistent inflammation, the current antibiotic treatments can lead emergence multidrug‐resistant bacteria. Herein, bimetallic nanozyme‐based biomimetic bio‐cocklebur (GNR@CeO 2 @GNPs) is designed synthesized for diabetic wound management by depositing spiky ceria (CeO ) shells gold nanoparticles (GNPs) on nanorod (GNR) nanoantenna. The plasmonic‐enhanced nanozyme catalysis self‐cascade reaction properties simultaneously boost two‐step enzyme‐mimicking catalytic activity GNR@CeO @GNPs, leading significant improvement in overall therapeutic efficacy rather than mere additive effects. Under glucose activation 808 nm laser irradiation, @GNPs material captures photons promotes transfer hot electrons from GNR GNPs into CeO , realizing “butterfly effect” consuming local glucose, overcoming limited antibacterial efficiency an individual PTT modality, providing substantial reactive oxygen species. In vitro vivo experiments demonstrate material's exceptional antibiofilm against Gram‐negative Gram‐positive bacteria, which reduce promote collagen deposition, facilitate angiogenesis, thereby accelerating healing. This study provides promising new strategy develop nanozymes with cascade mode antibiotic‐free synergistic treatment infected wounds.

Язык: Английский

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