Tetrahedron Chem,
Год журнала:
2023,
Номер
8, С. 100049 - 100049
Опубликована: Сен. 22, 2023
Transition-metal-catalyzed
allenes-involved
C–H
functionalizations
demonstrate
unique
selectivity
and
undergo
exceptional
pathways
due
to
the
existence
of
elusive
orthogonal
cumulative
C
bonds.
As
a
result,
it
allows
for
diverse
array
activation
reactions,
such
as
allylation,
alkenylation,
allenylation,
dienylation,
propargylation,
annulation.
In
this
review,
we
comprehensively
summarize
noteworthy
aspects
transition-metal-catalyzed
involving
variously
substituted
allenes.
Angewandte Chemie,
Год журнала:
2022,
Номер
134(36)
Опубликована: Июнь 28, 2022
Abstract
An
unprecedented
hydroalkylation
of
racemic
allylic
alcohols
and
ketimine
esters
enabled
by
Cu/Ru
relay
catalysis
has
been
developed
via
merging
the
ruthenium‐catalyzed
asymmetric
borrowing‐hydrogen
reaction
with
a
copper‐catalyzed
Michael
addition
in
one‐pot
procedure.
The
current
method
enables
efficient
preparation
highly
functionalized
δ‐hydroxyesters
bearing
1,4‐nonadjacent
stereocenters
good
yields
high
levels
diastereoselectivity
excellent
enantioselectivity
under
mild
conditions.
full
complement
four
stereoisomers
products
could
be
readily
accessed
orthogonal
permutations
two
chiral
metal
catalysts.
work
highlights
power
for
stereodivergent
construction
that
were
otherwise
inaccessible.
Chemical Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 6, 2024
Catalytic
enantioselective
hydrogen
autotransfer
reactions
for
the
direct
conversion
of
lower
alcohols
to
higher
are
catalogued
and
their
application
total
synthesis
polyketide
natural
products
is
described.
These
methods
exploit
a
redox
process
in
which
alcohol
oxidation
balanced
by
reductive
generation
organometallic
nucleophiles
from
unsaturated
hydrocarbon
pronucleophiles.
Unlike
classical
carbonyl
additions,
premetalated
reagents,
chiral
auxiliaries
discrete
alcohol-to-aldehyde
not
required.
Additionally,
chemoselective
dehydrogenation
primary
presence
secondary
enables
C-C
coupling
absence
protecting
groups.
Tetrahedron Chem,
Год журнала:
2023,
Номер
8, С. 100049 - 100049
Опубликована: Сен. 22, 2023
Transition-metal-catalyzed
allenes-involved
C–H
functionalizations
demonstrate
unique
selectivity
and
undergo
exceptional
pathways
due
to
the
existence
of
elusive
orthogonal
cumulative
C
bonds.
As
a
result,
it
allows
for
diverse
array
activation
reactions,
such
as
allylation,
alkenylation,
allenylation,
dienylation,
propargylation,
annulation.
In
this
review,
we
comprehensively
summarize
noteworthy
aspects
transition-metal-catalyzed
involving
variously
substituted
allenes.
