Selective Extraction and Quantification of Hemoglobin Based on a Novel Molecularly Imprinted Nanopolymeric Structure of Poly(acrylamide-vinyl imidazole)

ACS Omega, Год журнала: 2024, Номер 9(16), С. 18458 - 18468

Опубликована: Апрель 15, 2024

Imbalances in hemoglobin (Hb) levels can lead to conditions such as anemia or polycythemia, emphasizing the importance of precise Hb extraction from blood. To address this, a novel synthetic imprinted polymer was meticulously developed for capturing and separating Hb. Poly(acrylamide-vinylimidazole) nanopolymer (poly(AAm-VIM)) synthesized using acrylamide vinyl imidazole functional monomers through surfactant-free emulsion polymerization. Characterization FTIR, particle size, zeta potential, SEM ensured polymer's structure. The Hb-imprinted (Hb-poly(AAm-VIM)) demonstrated notable specificity, with calculated Hb-specific adsorption value (Qmax) 3.7377 mg/g medium containing 2.5 mg/mL molecularly (MIP) exhibited approximately 5 times higher than nonimprinted (NIP). Under same conditions, displayed 2.39 2.17 greater selectivity over competing proteins bovine serum albumin (BSA) lysozyme (Lys), respectively. Also, SDS-PAGE analysis results confirmed purification by nanopolymer. These underscore heightened specificity efficacy selectively targeting atoms among other proteins. Incorporating polymers is justified their affinity, cost-effectiveness, facile production. This research contributes valuable insights into optimizing efficient extraction, potential medical diagnostics treatment applications.

Язык: Английский

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Hole-transporting alternating copolymers for perovskite solar cells: thia[5]helicene comonomer outperforms planar perylothiophene analog

Energy & Environmental Science, Год журнала: 2024, Номер 17(11), С. 3937 - 3946

Опубликована: Янв. 1, 2024

Compared to planar perylothiophene, thiahelicene has been demonstrated as a superior co-monomer for crafting high-performance semiconducting polymer in n–i–p perovskite solar cells.

Язык: Английский

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The marriage of dual-acceptor strategy and C-H activation polymerization: naphthalene diimide-based n-type polymers with adjustable molar mass and decent performance

Science China Chemistry, Год журнала: 2022, Номер 66(2), С. 548 - 561

Опубликована: Дек. 22, 2022

Язык: Английский

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High-mobility organic mixed conductors with a low synthetic complexity index via direct arylation polymerization

Chemical Science, Год журнала: 2024, Номер 15(20), С. 7679 - 7688

Опубликована: Янв. 1, 2024

The synthesis of conjugated copolymers with glycolated thieno[3,2- b ]thiophene units by direct arylation polymerization, their synthetic complexity in the context literature compounds, and performance organic electrochemical transistors is described.

Язык: Английский

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Base-Assisted Polymerizations of Elemental Sulfur and Alkynones for Temperature-Controlled Synthesis of Polythiophenes or Poly(1,4-dithiin)s

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(51), С. 28204 - 28215

Опубликована: Дек. 15, 2023

With the increasing demand for functional polythiophenes in extensive applications such as organic solar cells, electronic skins, thermoelectric materials, and field effect transistors, efficient economic synthetic approaches are urgently required. In this work, KOH-assisted polymerizations of elemental sulfur alkynones were developed to directly afford with various backbones, regioselective structures, high molecular weights (Mns up 20700 g/mol) yields (up 97%) at 80 °C 30 min. When same polymerization was conducted room temperature, stable unique poly(1,4-dithiin)s 21800 could be rapidly obtained 87%) 10 The temperature-controlled possessed efficiency, mild conditions, simple operation, which had provided an economic, efficient, convenient approach direct conversion from situ constructed aromatic or nonaromatic heterocycles embedded polymer demonstrating great simplicity, good selectivity, robustness. It is anticipated accelerate development semiconducting materials their applications.

Язык: Английский

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An Efficient Direct Arylation Polycondensation via C−S Bond Cleavage

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(41)

Опубликована: Июнь 21, 2023

The direct arylation polycondensation (DArP) has become one of the most important methods to construct conjugated polymers (CPs). However, homocoupling side-reactions aryl halides and low regioseletive reactivities unfunctionalized aryls hinder development DArP. Here, an efficient Pd Cu co-catalyzed DArP was developed via inert C-S bond cleavage thioethers, which robustness exemplified by over twenty (CPs), including copolymers, homopolymers, random polymers. capture oxidative addition intermediate together with experimental theoretic results suggested role palladium (Pd) copper (Cu) co-catalysis a bicyclic mechanism. studies NMR, molecular weights, trap densities, two-dimensional grazing-incidence wide-angle X-ray scattering (2D-GIWAXS), charge transport mobilities revealed that reactions were significantly suppressed high regioselectivity aryls, suggesting this method is excellent choice for synthesizing performance CPs.

Язык: Английский

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Photo‐Induced Ruthenium‐Catalyzed C−H Arylation Polymerization at Ambient Temperature

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(25)

Опубликована: Апрель 18, 2024

Transition metal-catalyzed C-H arylation polymerization (CHAP) is an attractive tool for constructing π-conjugated polymers in a sustainable manner. However, the existing methods primarily rely on palladium catalysis, which usually entails harsh reaction conditions and branching/cross-linking. Here we report first example of ambient-temperature ruthenium-catalyzed induced by visible light irradiation. The present can produce various meta- para-linked excellent yields with high molecular weights. remarkable feature our mild platform represented chemoselectivity, leading to that are otherwise inaccessible under conventional at temperatures.

Язык: Английский

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6H-[1,2,5]Thiadiazolo[3,4-e]thieno[3,2-b]indole-flanked para-azaquinodimethane based aromatic-quinoidal polymer semiconductors with high molecular weights synthesized via direct arylation polycondensation

Materials Advances, Год журнала: 2023, Номер 4(8), С. 1927 - 1934

Опубликована: Янв. 1, 2023

The 6 H -[1,2,5]thiadiazolo[3,4- e ]thieno[3,2- b ]indole-flanked para -azaquinodimethane ( p -AQM)-based polymer semiconductors PQ-1 and PQ-2 are rationally designed through a π-extended aromatic-quinoidal design strategy.

Язык: Английский

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Regioregular Alternating Polychalcogenophenes‐Block‐Poly(3‐hexylthiophene): Synthesis, Structural Characterizations, Molecular Properties, and Transistors

Chemistry - An Asian Journal, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Abstract Sequence‐controlled polychalcogenophenes have attracted considerable attention in polymer science, particularly terms of their synthesis, structure, and functionality. In this work, we designed a new series alternating block conjugated copolymers, denoted as poly( alt ‐AB) b (3HT), where one consists an copolymer the other is poly(3‐hexylthiophene) (P3HT). To construct three sequence‐controlled polychalcogenophenes, utilized 3‐hexylthiophene (S), 3‐hexylselenophene (Se), 3‐hexyltellurophene (Te) A B units, yielding P(SSe) P(STe) P(SeTe) respectively. These polymers were synthesized via nickel‐catalyzed Kumada polymerization by sequentially introducing two different Grignard monomers. Through catalyst‐transfer polycondensation (CTP), achieved precise control over molecular weight, dispersity, length, main chain sequence. The structures with high side regioregularity both blocks definitively confirmed using ¹H ¹ 3 C NMR analyses. Grazing‐incidence wide‐angle X‐ray scattering (GIWAXS) revealed that all predominantly adopt edge‐on orientation solid state. organic field‐effect transistor (OFET) measurements, (3HT) exhibited highest hole mobility 4.4 × 10⁻ 2 cm V⁻¹ s⁻¹, attributed to its highly ordered packing thin films. Notably, 2.9 among reported for tellurophene‐containing polychalcogenophenes.

Язык: Английский

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Open-flask, ambient temperature direct arylation synthesis of mixed ionic-electronic conductors

Science Advances, Год журнала: 2025, Номер 11(19)

Опубликована: Май 7, 2025

Conjugated polymers are widely studied for application areas ranging from energy technology to wearable electronics and bioelectronics. To develop a truly sustainable technology, environmentally benign synthesis is essential. Here, the open-flask of multitude conjugated at room temperature by ambient direct arylation polymerization (ADAP) demonstrated. The batch over 100 grams polymer in green solvent continuous droplet flow without any solid support described. Polymers prepared ADAP characterized improved structural order compared materials other methods. Hence, organic electrochemical transistors (OECTs) feature beyond state-of-the-art electrical properties, i.e., an OECT hole mobility μ as high 6 cm 2 V −1 s , volumetric capacitance C * 200 F −3 thus figure merit [μ ] exceeding 1100 . Thus, paves way large-scale production high-performance polymers.

Язык: Английский

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