Chemistry - An Asian Journal,
Год журнала:
2022,
Номер
17(23)
Опубликована: Сен. 26, 2022
Ru(II)-catalyzed
C-H
bond
activation
strategy
has
been
capitalized
through
a
(4+2)
annulative
difunctionalization
of
non-conjugated
alkenyl
amides.
Under
mild
conditions,
broad
range
(hetero)aromatic
amides
embedded
with
NH-OMe
unit
as
an
internal
oxidant
produced
high-value
dihydroisoquinolinone
scaffolds
in
good
to
excellent
yields.
This
heteroannulation
is
also
effective
acrylamides
dispense
dihydro-2-pyridones
and
accommodates
bioactive
such
tocopherol,
estrone,
amino
acids.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(10), С. 2505 - 2516
Опубликована: Янв. 1, 2023
A
new
nickel
catalysis
strategy
that
harnesses
readily
accessible
alkyl
xanthate
esters,
while
previously
well-studied
as
radical
precursors,
herein
ideal
sulfenylating
agents
via
an
unprecedented
C–S
bond
activation
pattern.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Ноя. 28, 2024
The
transition
metal-catalysed
dicarbofunctionalisation
of
unactivated
alkenes
normally
requires
exogenous
strong
coordinated
directing
groups,
thus
reducing
the
overall
reaction
efficiency.
Here,
we
report
a
ligand-enabled
Ni(II)-catalysed
with
aryl/alkenyl
boronic
acids
and
alkyl
halides
as
coupling
partners
diverse
range
native
functional
groups
group.
This
protocol
provides
an
efficient
direct
route
towards
vicinal
1,2-disubstituted
alkanes
using
primary,
secondary,
tertiary
amides,
sulfonamides,
well
secondary
amines
under
redox-neutral
conditions
that
are
challenging
to
access
through
conventional
methods.
key
success
this
is
use
bulky
β-diketone
ligand,
which
could
enable
insertion
alkene
aryl-Ni(II)
species,
stabilize
alkyl-Ni(II)
species
inhibit
homolytic
cleavage,
supporting
by
both
experimental
computational
studies.
features
group,
broad
substrate
scope,
excellent
scalability.
groups.
authors
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
21(38), С. 7724 - 7729
Опубликована: Янв. 1, 2023
A
visible-light-driven
organophotocatalyzed
multi-component
approach
for
carbothiolation
of
activated
alkenes
is
demonstrated
under
environmentally
benign
and
redox-neutral
conditions,
involving
direct
C(sp3)-H
functionalization
followed
by
electrophilic
alkyl/arylthiolation.
The
three-component
difunctionalization
reaction
a
complete
transition-metal
peroxide-free
process
conducted
milder
conditions.
In
this
composite
reaction,
employing
bench-stable
reagents,
the
formation
two
new
C(sp3)-C(sp3)
C(sp3)-S
bonds
achieved
wide
variety
substrates,
showcasing
excellent
functional
group
tolerance
chemoselectivity
methodology.
Furthermore,
scalability
utilization
natural
sunlight
instead
artificial
blue
LEDs,
along
with
use
an
inexpensive
easy-to-prepare
pyrylium
salt
as
organo-photocatalyst,
make
protocol
greener
more
energy
efficient.
Organic Letters,
Год журнала:
2023,
Номер
25(13), С. 2172 - 2177
Опубликована: Март 22, 2023
An
expeditious
and
novel
nickel-catalyzed
selective
arylhydroxylation
of
unactivated
alkenes
with
arylboronic
acids
was
developed.
This
protocol
is
compatible
β,γ-
γ,δ-alkene
amides,
including
traditionally
challenging
internal
alkenes,
to
provide
important
β-arylethylalcohol
scaffolds.
The
free
hydroxyl
group
in
the
final
product
could
be
smoothly
further
transformed
into
other
functional
groups.
Control
experiments
indicated
that
oxygen
atom
derived
from
air.
Chemistry - An Asian Journal,
Год журнала:
2022,
Номер
17(23)
Опубликована: Сен. 26, 2022
Ru(II)-catalyzed
C-H
bond
activation
strategy
has
been
capitalized
through
a
(4+2)
annulative
difunctionalization
of
non-conjugated
alkenyl
amides.
Under
mild
conditions,
broad
range
(hetero)aromatic
amides
embedded
with
NH-OMe
unit
as
an
internal
oxidant
produced
high-value
dihydroisoquinolinone
scaffolds
in
good
to
excellent
yields.
This
heteroannulation
is
also
effective
acrylamides
dispense
dihydro-2-pyridones
and
accommodates
bioactive
such
tocopherol,
estrone,
amino
acids.
