Applications of Graphene in Five Senses, Nervous System, and Artificial Muscles

ACS Sensors, Год журнала: 2023, Номер 8(2), С. 482 - 514

Опубликована: Янв. 19, 2023

Graphene remains of great interest in biomedical applications because biocompatibility. Diseases relating to human senses interfere with life satisfaction and happiness. Therefore, the restoration by artificial organs or sensory devices may bring a bright future recovery patients. In this review, we update most recent progress graphene based sensors for mimicking such as retina image sensors, eardrums, gas chemical tactile sensors. The brain-like processors are discussed on conventional transistors well memristor related neuromorphic computing. brain–machine interface is introduced providing single pathway. Besides, muscles summarized means actuators order react physical world. Future opportunities remain elevating performances human-like their clinical applications.

Язык: Английский

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Recent advancements in nucleic acid detection with microfluidic chip for molecular diagnostics

TrAC Trends in Analytical Chemistry, Год журнала: 2022, Номер 158, С. 116871 - 116871

Опубликована: Дек. 5, 2022

Язык: Английский

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Ultrathin Conductive Bithiazole‐Based Covalent Organic Framework Nanosheets for Highly Efficient Electrochemical Biosensing

Advanced Functional Materials, Год журнала: 2023, Номер 33(36)

Опубликована: Май 26, 2023

Abstract Covalent organic frameworks (COFs) with unique structural merits show substantial potential in the construction of biosensors. However, high‐performance COF‐based biosensors have rarely been reported due to special requirements for electrochemical biosensing. Here, ultrathin nitrogen and sulfur‐rich bithiazole‐based COF nanosheets (COF‐Bta‐NSs) thickness ≈1.95 nm are developed by using an interfacial perturbation growth strategy, further integrated acetylcholinesterase (AChE) through strong supramolecular interactions construct a biosensor organophosphorus pesticides (OPs) detection. By virtue excellent electrical conductivity abundant edge unsaturated sites COF‐Bta‐NSs, such can be used detection various OPs, showing wide range, ultralow limit, high stability. Significantly, portable biosensing device is set up based on commercialized screen‐printed electrode (SPE), which sensitive reliable actual samples collected from river water leafy vegetables, confirming practical applicability. This research provides novel insight into development advanced performance biological environmental analysis.

Язык: Английский

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High-Efficiency 3D DNA Walker Immobilized by a DNA Tetrahedral Nanostructure for Fast and Ultrasensitive Electrochemical Detection of MiRNA

Analytical Chemistry, Год журнала: 2023, Номер 95(8), С. 4077 - 4085

Опубликована: Фев. 14, 2023

Herein, by directly limiting the reaction space, an ingenious three-dimensional (3D) DNA walker (IDW) with high walking efficiency is developed for rapid and sensitive detection of miRNA. Compared traditional walker, IDW immobilized tetrahedral nanostructure (DTN) brings stronger kinetic thermodynamic favorability resulting from its improved local concentration space confinement effect, accompanied a quite faster speed much better efficiency. Once traces target miRNA-21 react prelocked IDW, could be largely activated walk on interface electrode to trigger cleavage H2 assistance Mg2+, in release amounts methylene blue (MB) labeled surface obvious decrease signal. Impressively, reveals conversion as 9.33 × 108 30 min fast speed, which at least five times beyond that typical walkers. Therefore, address inherent challenges easily: slow low Notably, nanomachine was utilized construct sensing platform limit (LOD) 19.8 aM realize highly assay biomarker total RNA lysates cancer cell. The strategy thus helps design versatile nucleic acid signal amplification approach practical applications areas biosensing assay, nanotechnology, clinical diagnosis.

Язык: Английский

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Interface‐Engineered Field‐Effect Transistor Electronic Devices for Biosensing

Advanced Materials, Год журнала: 2023, Номер unknown

Опубликована: Дек. 4, 2023

Promising advances in molecular medicine have promoted the urgent requirement for reliable and sensitive diagnostic tools. Electronic biosensing devices based on field-effect transistors (FETs) exhibit a wide range of benefits, including rapid label-free detection, high sensitivity, easy operation, capability integration, possessing significant potential application disease screening health monitoring. In this perspective, tremendous efforts achievements development high-performance FET biosensors past decade are summarized, with emphasis interface engineering FET-based electrical platforms biomolecule identification. First, an overview strategies modulation recognition element design is discussed detail. For further step, applications vitro detection real-time monitoring biological systems comprehensively reviewed. Finally, key opportunities challenges electronic discussed. It anticipated that comprehensive understanding will inspire additional techniques developing highly sensitive, specific, stable as well emerging designs next-generation electronics.

Язык: Английский

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Graphene Transistors for In Vitro Detection of Health Biomarkers

Advanced Functional Materials, Год журнала: 2023, Номер 33(31)

Опубликована: Май 10, 2023

Abstract Biomarkers are primary indicators for precise diagnosis and treatment. The early identification of health biomarkers has been sustained by the evolutionary success in sensor technologies. Among them, graphene field‐effect transistor (GFET) biosensors have exhibited major advantages such as an ultrashort response time, high sensitivity, easy operation, capability integration, label‐free detection. Owing to atomic thickness, restricts charge carrier flow merely at material surface responds foreign stimuli directly, leading effective signal acquisition transmission. Here, this review summarizes latest advances GFET a comprehensive manner that contains device design, working principle, functionalization, proof‐of‐concept applications. It provides survey with regard biomarker analysis single‐device level integrated prototypes include wearable sensors, biomimetic systems, healthcare electronics, diagnostic platforms. Moreover, there is discussion on long‐standing research efforts outlook future development systems from lab fab.

Язык: Английский

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Nanotechnology-Assisted Biosensors for the Detection of Viral Nucleic Acids: An Overview

Biosensors, Год журнала: 2023, Номер 13(2), С. 208 - 208

Опубликована: Янв. 30, 2023

The accurate and rapid diagnosis of viral diseases has garnered increasing attention in the field biosensors. development highly sensitive, selective, accessible biosensors is crucial for early disease detection preventing mortality. However, developing optimized several limitations, including mutations. For decades, nanotechnology been applied numerous biological fields such as biosensors, bioelectronics, regenerative medicine. Nanotechnology offers a promising strategy to address current limitations conventional nucleic acid-based implementation nanotechnologies, functional nanomaterials, nanoplatform-fabrication techniques, surface nanoengineering, not only improved performance but also expanded range sensing targets. Therefore, deep understanding combination nanotechnologies required prepare sanitary emergencies recent COVID-19 pandemic. In this review, we provide interdisciplinary information on nanotechnology-assisted First, representative are discussed, after which review summarizes various acid expect that will valuable basis novel

Язык: Английский

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RNA extraction-free workflow integrated with a single-tube CRISPR-Cas-based colorimetric assay for rapid SARS-CoV-2 detection in different environmental matrices

Journal of Hazardous Materials, Год журнала: 2023, Номер 454, С. 131487 - 131487

Опубликована: Апрель 25, 2023

Язык: Английский

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DNA Tile and Invading Stacking Primer-Assisted CRISPR–Cas12a Multiple Amplification System for Entropy-Driven Electrochemical Detection of MicroRNA with Tunable Sensitivity

Analytical Chemistry, Год журнала: 2023, Номер 95(36), С. 13659 - 13667

Опубликована: Авг. 25, 2023

Conventional electrochemical detection of microRNA (miRNA) encounters issues poor sensitivity and fixed dynamic range. Here, we report a DNA tile invading stacking primer-assisted CRISPR-Cas12a multiple amplification strategy to construct an entropy-controlled biosensor for the miRNA with tunable To amplify signal, cascade system along primer signal (ISPSA) was designed detect trace amounts miRNA-31 (miR-31). The target miR-31 could activate ISPSA produce numerous DNAs, triggering cleavage single-stranded linker probe (LP) that connects methylene blue-labeled tetrahedron form Y-shaped scaffold on electrode. Based decrease current, can be accurately efficiently detected. Impressively, by changing loop length LP, it is possible finely tune entropic contribution while keeping enthalpic constant. This has shown limit from 0.31 fM 0.56 pM, as well range ∼2200-fold ∼270,000-fold. Moreover, demonstrated satisfactory results in identifying cancer cells high expression miR-31. Our broadens application conventional biosensing provides detecting miRNAs at varying concentrations.

Язык: Английский

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Graphene-Based Electrochemical Nano-Biosensors for Detection of SARS-CoV-2

Inorganics, Год журнала: 2023, Номер 11(5), С. 197 - 197

Опубликована: Май 1, 2023

COVID-19, a viral respiratory illness, is caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2), which was first identified in Wuhan, China, 2019 and rapidly spread worldwide. Testing isolation were essential to control the virus’s transmission due severity of disease. In this context, there global interest feasibility employing nano-biosensors, especially those using graphene as key material, for real-time detection virus. The exceptional properties outstanding performance nano-biosensors identifying various viruses prompted check on technology. This paper focuses recent advances graphene-based electrochemical biosensors sensing SARS-CoV-2 Specifically, it reviews types biosensors, including amperometric, potentiometric, impedimetric discusses current challenges associated with detection. conclusion review future directions field detection, underscoring importance continued research development domain.

Язык: Английский

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