ABSTRACT
Cancer
research
predominantly
centers
on
diagnosis,
treatment,
and
elucidation
of
underlying
mechanisms.
Nevertheless,
the
intricate
nature
tumor
genesis
development
has
rendered
early
diagnostic
therapeutic
outcomes
less
than
optimal,
making
conquest
a
formidable
challenge.
The
interdisciplinary
fusion
medicine
engineering,
termed
“intersection
engineering”,
emerged
as
groundbreaking
paradigm,
offering
novel
avenues
for
advancing
cancer
studies.
As
this
approach
evolves,
it
yielded
numerous
breakthroughs
in
mechanistic
exploration.
In
review,
we
summarize
how
intersection
engineering
propels
progress
by
leveraging
combined
strengths
medicine,
bioinformatics,
materials
science,
artificial
intelligence.
This
addresses
limitations
traditional
diagnostics
therapies,
such
low
sensitivity,
poor
efficacy,
significant
side
effects,
challenges
associated
with
Moreover,
highlight
global
cutting‐edge
advancements
potential
future
directions
field.
Resources Chemicals and Materials,
Год журнала:
2024,
Номер
3(2), С. 103 - 122
Опубликована: Янв. 15, 2024
4,4-Difluoro-4-bora-3a,4a-diaza-sindacene
(BODIPY)
is
a
sort
of
photofunctional
dye
which
possesses
advantages
including
strong
light-capturing
property,
high
photon-resistance,
etc.
Meso-N
substituted
aza-BODIPY
crucial
derivative
BODIPY
scaffold
that
has
the
favorable
optical
properties
and
significant
spectral
redshift.
The
photophysical
can
be
tuned
by
molecular
design,
attenuation
path
excited
state
energy
release
absorbed
light
well
controlled
via
structural
modifications,
enabling
tailored
application.
It
been
extensively
employed
in
life
medicine
fields
fluorescence
imaging
diagnosis,
photodynamic
therapy
photosensitizer
photothermal
reagent
so
forth.
Extensive
research
review
have
performed
these
areas.
However,
BODIPYs/aza-BODIPYs
role
energy,
catalysis,
optoelectronics,
photo-responsive
materials
other
fields.
Nevertheless,
there
are
relatively
few
studies
reviews
on
modification
application
based
BODIPY/aza-BODIPY
scaffold.
Herein,
this
we
summarized
aforementioned
fields,
with
regulation
as
foundation
utilization
above
objective,
intention
providing
inspiration
for
exploration
innovative
field
resource
conversion
functional
materials.
ACS Central Science,
Год журнала:
2024,
Номер
10(4), С. 842 - 851
Опубликована: Март 21, 2024
Degenerative
diseases
are
closely
related
to
the
changes
of
protein
conformation
beyond
steady
state.
The
development
feasible
tools
for
quantitative
detection
in
cellular
environment
is
crucial
investigating
process
conformational
variations.
Here,
we
have
developed
a
near-infrared
AIE
probe
based
on
rhodamine
fluorophore,
which
exhibits
dual
responses
fluorescence
intensity
and
lifetime
local
viscosity
changes.
Notably,
computational
analysis
reveals
that
NRhFluors
activation
due
inhibition
RACI
mechanism
viscous
environment.
In
chemical
regulation
fluorophores,
found
variations
electron
density
distribution
can
effectively
regulate
CI
states
achieve
sensitivity
NRhFluors.
addition,
combined
with
AggTag
method,
A9-Halo
positive
correlation
This
analytical
capacity
allows
us
quantitatively
monitor
using
imaging
(FLIM)
demonstrate
mitochondrial
dysfunction
leads
reduced
expression
HEK293
cells.
summary,
this
work
set
probes
activated
by
mechanism,
detect
cell
aggregation
formation,
providing
versatile
tool
exploring
disease-related
biological
processes
therapeutic
approaches.
Nano Letters,
Год журнала:
2024,
Номер
24(31), С. 9675 - 9682
Опубликована: Июль 26, 2024
Feeding
silkworms
with
functional
materials
as
additives
to
produce
naturally
modified
silk
is
a
facile,
diverse,
controllable,
and
environmentally
friendly
method
low
cost
of
time
investment.
Among
various
additives,
carbon
dots
(CDs)
show
unique
advantages
due
their
excellent
biocompatibility
fluorescence
stability.
Here,
new
type
green
fluorescent
(G-CDs)
synthesized
high
oil–water
partition
ratio
147,
isoelectric
point
5.16,
an
absolute
quantum
yield
71%,
critically
controlled
surface
states.
After
feeding
G-CDs,
the
weave
light
yellow
cocoons
whose
visible
naked
eye
under
UV
light.
The
luminous
sewn
onto
cloth
create
striking
patterns
beautiful
fluorescence.
Such
G-CDs
have
no
adverse
effect
on
survival
rate
life
cycle
enable
whole
bodies
glow
Based
strong
fluorescence,
chemical
stability,
biological
safety,
are
found
in
digestive
tracts,
glands,
feces,
cocoons,
even
moth
bodies.
accumulate
posterior
glands
where
fibroin
protein
secreted,
indicating
its
stronger
combination
than
sericin,
which
meets
requirements
for
practical
applications.
ACS Applied Optical Materials,
Год журнала:
2023,
Номер
1(3), С. 640 - 651
Опубликована: Фев. 27, 2023
Photoactivatable
fluorophores
provide
the
opportunity
to
switch
fluorescence
on
exclusively
in
a
selected
area
within
sample
of
interest
at
precise
interval
time.
Such
level
spatiotemporal
control
enables
implementation
imaging
schemes
monitor
dynamic
events
real
time
and
visualize
structural
features
with
nanometer
resolution.
These
transformative
methods
are
contributing
fundamental
insights
diverse
cellular
processes
profound
implications
biology
medicine.
Current
photoactivatable
fluorophores,
however,
become
emissive
only
after
activation
event,
preventing
acquisition
images
and,
hence,
visualization
prior
activation.
We
developed
family
capable
interconverting
between
states
spectrally
resolved
fluorescence,
instead
switching
from
nonemissive
state
an
one.
demonstrated
that
our
compounds
allow
real-time
monitoring
molecules
diffusing
across
blastoderm
developing
embryos
as
well
polymer
beads
translocating
along
intestinal
tract
live
nematodes.
Additionally,
they
also
permit
tracking
single
lysosomal
compartments
cells
these
organelles
Indeed,
may
evolve
into
invaluable
analytical
tools
for
investigation
factors
regulating
functions
structures
molecular
level.
Advanced Optical Materials,
Год журнала:
2023,
Номер
12(1)
Опубликована: Авг. 27, 2023
Abstract
Organic
luminophores
with
high
emission
efficiency
in
solution
as
well
solid‐state
have
received
increasing
attention
due
to
their
promising
applications
biosensors,
biological
imaging,
and
optoelectronic
devices.
Herein,
four
triphenylamine
(TPA)‐substituted
boron
ketoimine
molecules
(TPA‐BKI
a‐d)
are
designed
synthesized
by
combining
a
donor‐acceptor
(D‐A)
electronic
system
highly
twisted
block.
The
asymmetry
of
molecular
the
planarity
highest
occupied
orbital
(HOMO)
lowest
unoccupied
(LUMO)
sides
excited
state
endow
TPA‐BKI
a‐d
rigidified
conformations,
allowing
bright
dilute
solution.
Additionally,
structures
avoid
close
contact
between
detrimental
exciton
interactions,
leading
efficient
solid
state.
Meanwhile,
colors
modulated
incorporation
different
substituents
through
amino‐yne
click
reaction.
Furthermore,
because
protonation
deprotonation
amino
substituents,
TPA‐BKI‐d
exhibits
reversible
alterations
optical
properties
both
states.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(21), С. 5140 - 5149
Опубликована: Янв. 1, 2024
We
explored
a
new
way
of
utilizing
the
ESP
difference
to
improve
molecular
packing
(A–D–A)
type
molecules,
and
obtained
series
NIR
PTAs
with
good
PTT
performance.
The
in
vivo
antitumor
study
demonstrates
effective
suppression
tumors.
