Molecules,
Год журнала:
2024,
Номер
29(23), С. 5498 - 5498
Опубликована: Ноя. 21, 2024
alkaloids
(DAs)
are
interesting
molecules
with
rich
molecular
skeletons
and
diverse
biological
activities.
Since
their
discovery,
phytochemists
have
isolated,
purified,
identified
more
than
350
DAs.
Synthetic
chemists,
attracted
by
the
structure
activity
of
DAs,
accomplished
many
elegant
synthetic
jobs.
Herein,
we
summarize
work
on
isolation,
structural
identification,
bioactivity
testing,
synthesis
DAs
from
2018
to
2023,
aim
providing
a
reference
for
future
studies.
Organic Letters,
Год журнала:
2022,
Номер
24(51), С. 9520 - 9524
Опубликована: Дек. 16, 2022
The
[7–5–5]
tricyclic
core
of
daphniphyllum
alkaloids,
containing
contiguous
stereogenic
centers
at
C14
and
C15
a
tetrasubstituted
alkene
moiety
between
C9
C10,
was
constructed
via
cascade
reaction
that
involved
an
electrocyclic
pentadienyl
cation
intramolecular
interception
the
resultant
cyclopentenyl
cation.
Angewandte Chemie,
Год журнала:
2023,
Номер
135(23)
Опубликована: Март 30, 2023
Abstract
The
daphnezomine
A‐type
subfamily
of
Daphniphyllum
alkaloids
structurally
features
a
unique
aza‐adamantane
core
skeleton
and
anticipates
efficient
strategies
for
completing
their
syntheses
to
thoroughly
investigate
biological
activities.
Herein,
divergent
total
(−)‐daphnezomines
A
B
(+)‐dapholdhamine
have
been
accomplished
in
16–20
steps
from
known
epoxide
via
rapid
construction
common
intermediate.
present
work
Ti‐mediated
radical
cyclization
establish
the
azabicyclo[3.3.1]nonane
ring
system,
an
intramolecular
Heck
reaction
install
bridgehead
all‐carbon
quaternary
stereocenter,
tandem
deprotection/reduction/keto
amine‐carbinolamine
tautomerization
furnish
backbone,
NIS‐promoted
6‐
endo
‐trig
aminocyclization
assemble
backbone.
