Advanced NanoBiomed Research,
Год журнала:
2024,
Номер
4(3)
Опубликована: Янв. 24, 2024
Photothermal
therapy
(PTT)
has
emerged
as
a
promising
approach
for
tumor
ablation
utilizing
hyperthermia
offers
several
advantages,
including
non‐invasiveness,
spatiotemporal
controllability,
and
notable
therapeutic
efficacy.
However,
the
clinical
application
of
PTT
is
challenged
by
heat
diffusion.
To
address
this,
mild
(mPTT)
gained
attention
an
alternative
strategy,
operating
at
temperatures
below
45
°C,
with
remarkable
antitumor
effects
minimal
thermal
damage
to
nearby
normal
tissues.
Despite
these
benefits,
expression
shock
proteins
(HSPs)
induces
resistance,
which
limits
potential
practical
implementation
mPTT.
Nanomedicines
have
solution
overcome
challenges,
offering
improved
solubility,
prolonged
circulation
time,
enhanced
accumulation,
controlled
cargo
release,
surpassing
capabilities
small
molecular
HSP
inhibitors.
Herein,
it
been
aimed
discuss
current
landscape
photothermal
agents,
elucidate
underlying
mechanisms
mPTT,
highlight
benefits
mPTT
in
combination
therapy,
explore
nanomedicines
enhance
Additionally,
future
directions
development
are
presented
challenges
that
needed
be
addressed
identified,
aim
encouraging
further
research
contributions
advance
toward
applications.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(46)
Опубликована: Авг. 2, 2024
Abstract
Tumor
microenvironment
(TME)‐responsive
nanozymes‐based
catalytic
therapy
shows
great
potential
in
combating
malignant
tumor.
However,
their
biological
application
still
suffers
from
deficient
activity.
Herein,
the
MoO
x
‐Rh
metallene
nanozyme
demonstrates
highly
efficient
multiple
enzymatic
activities,
where
species
atomically
dispersed
on
Rh
surface.
The
resulting
structures
enable
with
maximally
exposed
active
oxide‐metallene
interface
and
more
atoms
sites
around
can
be
well
finely
regulated.
Results
of
experiment
density
functional
theory
(DFT)
simulations
support
notion
that
atomic
structure
facilitates
enzyme‐like
reactions.
As
a
TME‐responsive
nanozyme,
exhibits
remarkable
therapeutic
effect
tumor
due
to
intrinsic
near‐infrared
photothermal
laser‐enhanced
activities.
This
study
illustrates
promise
engineering
strategy
therapy.
Numerous
attempts
for
organic
radical
stability
mostly
entail
steric
hindrance,
spin-delocalization,
supramolecular
interaction
with
the
host,
π-π
interactions,
and
hydrogen
bonding.
To
date,
there
is
no
report
of
single
crystals
containing
a
hydroxyl
(•OH).
In
this
work,
we
have
stabilized
•OH
in
crystal,
which
has
been
obtained
from
filtrate
after
separating
precipitate
chromenopyridine
(DCP(2)•)
reaction
mixture.
DCP(2)•
abstracts
atom
dissolved
water
ethanolic
to
grow
crystal
DCPH(2)
asymmetric
unit.
The
packing
computational
studies
suggest
that
π-•OH
•OH···N
hydrogen-bonding
interactions
are
responsible
stabilizing
•OH.
presence
further
confirmed
by
mass
analysis
2,2,6,6-tetramethylpiperidin-1-yl)oxyl
(TEMPO)
adduct.
Solid-state
electron
paramagnetic
resonance
(EPR),
solution
state
nitroblue
tetrazolium
(NBT)
assay,
spin
trapping
5,5-dimethyl-1-pyrroline
N-oxide
(DMPO)
super
oxide
dismutase
formation
crystal.
Advanced NanoBiomed Research,
Год журнала:
2024,
Номер
4(3)
Опубликована: Янв. 24, 2024
Photothermal
therapy
(PTT)
has
emerged
as
a
promising
approach
for
tumor
ablation
utilizing
hyperthermia
offers
several
advantages,
including
non‐invasiveness,
spatiotemporal
controllability,
and
notable
therapeutic
efficacy.
However,
the
clinical
application
of
PTT
is
challenged
by
heat
diffusion.
To
address
this,
mild
(mPTT)
gained
attention
an
alternative
strategy,
operating
at
temperatures
below
45
°C,
with
remarkable
antitumor
effects
minimal
thermal
damage
to
nearby
normal
tissues.
Despite
these
benefits,
expression
shock
proteins
(HSPs)
induces
resistance,
which
limits
potential
practical
implementation
mPTT.
Nanomedicines
have
solution
overcome
challenges,
offering
improved
solubility,
prolonged
circulation
time,
enhanced
accumulation,
controlled
cargo
release,
surpassing
capabilities
small
molecular
HSP
inhibitors.
Herein,
it
been
aimed
discuss
current
landscape
photothermal
agents,
elucidate
underlying
mechanisms
mPTT,
highlight
benefits
mPTT
in
combination
therapy,
explore
nanomedicines
enhance
Additionally,
future
directions
development
are
presented
challenges
that
needed
be
addressed
identified,
aim
encouraging
further
research
contributions
advance
toward
applications.
