Dalton Transactions, Год журнала: 2023, Номер 52(42), С. 15216 - 15232
Опубликована: Янв. 1, 2023
Photocatalytic organic conversion is considered an efficient, environmentally friendly, and energy-saving strategy for synthesis. Porous molecular cages exhibit significant potential in the realm of photocatalytic conversion.
Язык: Английский
Chemical Society Reviews, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
This article provides a comprehensive overview of recent advances in the development bioorthogonally activated probes for labelling and precise situ fluorescence imaging both vitro vivo .
Язык: Английский
Процитировано
7
Journal of Medicinal Chemistry, Год журнала: 2023, Номер 66(24), С. 16546 - 16567
Опубликована: Дек. 12, 2023
Time- and space-resolved drug delivery is highly demanded for cancer treatment, which, however, can barely be achieved with a traditional prodrug strategy. In recent years, the strategy based on bioorthogonal bond cleavage chemistry has emerged advantages of high temporospatial resolution over activation homogeneous irrespective individual heterogeneity. past five tremendous progress been witnessed in this field one such entering Phase II clinical trials. This Perspective aims to highlight these new advances (2019–2023) critically discuss their pros cons. addition, remaining challenges potential strategic directions future will also included.
Язык: Английский
Процитировано
14
Advanced Materials, Год журнала: 2024, Номер 36(41)
Опубликована: Авг. 16, 2024
Abstract Bioorthogonal chemistry has provided an elaborate arsenal to manipulate native biological processes in living systems. As the great advancement of nanotechnology recent years, bioorthogonal nanozymes are innovated tackle challenges that emerged practical biomedical applications. uniquely positioned owing their advantages high customizability and tunability, as well good adaptability systems, which bring exciting opportunities for More intriguingly, offers opportunity innovating catalytic materials. In this comprehensive review, significant progresses discussed with both spatiotemporal controllability performance highlight design principles rapid The remaining future perspectives then outlined along thriving field. It is expected review will inspire promote novel nanozymes, facilitate clinical translation.
Язык: Английский
Процитировано
6
Cell chemical biology, Год журнала: 2023, Номер 31(3), С. 409 - 427
Опубликована: Окт. 13, 2023
Язык: Английский
Процитировано
13
ChemCatChem, Год журнала: 2024, Номер 16(14)
Опубликована: Янв. 12, 2024
Abstract The chemical modification of proteins serves as a fundamental tool for understanding biological processes and enables the design biofunctional materials. Among available methodologies, photochemical strategies have garnered significant attention because their remarkable biocompatibility precise spatiotemporal reaction control. Developing novel reactions tailored to specific applications necessitates comprehensive photoreactive properties, including catalyst structures, appropriate modifiers, conditions. This review discusses modifications using an array catalysts, photoredox catalysts single‐electron transfer (SET), energy transfer, long‐wavelength excitable photocatalysts, genetically encoded artificial metalloenzymes. discussion covers unique attributes, mechanisms, practical applications, future prospects each catalyst‐driven reaction, shedding light on evolving landscape protein modifications.
Язык: Английский
Процитировано
5
Current Opinion in Cell Biology, Год журнала: 2024, Номер 88, С. 102360 - 102360
Опубликована: Апрель 18, 2024
Cells generate a highly diverse microtubule network to carry out different activities. This is comprised of distinct tubulin isotypes, tubulins with post-translational modifications, and many microtubule-based structures. Defects in this complex system cause numerous human disorders. However, how subtypes regulate cellular architectures activities remains largely unexplored. Emerging tools such as photosensitive pharmaceuticals, chemogenetics, optogenetics enable the spatiotemporal manipulation structures, dynamics, cross-linking actin filaments target subtypes. review summarizes design rationale applications these new approaches aims provide roadmap for researchers navigating intricacies dynamics their modifications contexts, thereby opening avenues therapeutic interventions.
Язык: Английский
Процитировано
4
Journal of the American Chemical Society, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 30, 2024
The revolutionary impact of photoredox catalytic processes has ignited novel avenues for exploration, empowering us to delve into nature in unprecedented ways and pioneer innovative biotechnologies therapy diagnosis. However, integrating artificial catalysis living systems presents significant challenges, primarily due concerns over low targetability, compatibility with complex biological environments, the safety risks associated photocatalyst toxicity. To address these herein, we present a bioorthogonally activatable approach. In this approach, potent selection via atom replacement rhodamine core yielded (PC-Tz). introduction 1,2,4,5-tetrazine quenched its photocatalytic properties, which were restored upon an intracellular inverse electron-demand Diels–Alder (iEDDA) reaction trans-cyclooctene (TCO) localized mitochondria. This led remarkable oxidation nicotinamide adenine dinucleotide (NADH), effectively manipulating mitochondrial electron transport chain (ETC) under hypoxic conditions cancer cells. Additionally, pyroptotic cell death was observed through caspase-3/gasdermin E (GSDME) pathway, achieving notable antitumor efficacy adenosine triphosphate (ATP) reduction tumor best our knowledge, represents first example catalysis, opening new chemists spatiotemporally control activity specific organelles without disrupting other native processes.
Язык: Английский
Процитировано
4
The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 19, 2025
Alpha-pyrones have been used for applications ranging from total synthesis to antibiotics. However, their application as dienes in bioorthogonal reactions has not extensively explored. In previous work, we demonstrated the promising of ester-functionalized pyrones protein labeling. Here, constructed a library substituted evaluate potential by exploring relationships among structure, reactivity, and bioorthogonality. We found that most pyrone derivatives with electron-withdrawing groups exhibited reactivity toward endo-bicyclo[6.1.0]nonyne (BCN), producing tricyclic tetracyclic products good yields. As expected, more stronger substituents showed faster reaction kinetics BCN. Bicyclic substantially decreased likely resulting increased steric effects. Counterintuitively, substitutions at positions 4 5 affected than those 3 6. To provide insights into both expected counterintuitive reactivities members, performed quantum chemical analysis. Additionally, evaluated each pyrone's L-cysteine no correlation between BCN cysteine-based Finally, collection popular dienophiles reactions.
Язык: Английский
Процитировано
0
Bioorganic Chemistry, Год журнала: 2025, Номер 157, С. 108320 - 108320
Опубликована: Фев. 26, 2025
Язык: Английский
Процитировано
0
Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(16)
Опубликована: Апрель 16, 2025
Most bioorthogonal photouncaging reactions preferentially occur in polar environments to accommodate biological applications the aqueous cellular milieu. However, they are not precisely designed chemically adapt diverse microenvironments of cell. Herein, we report a hydrophobic reaction with tailored photolytic kinetics toward solvent polarity. Structural modulations aminobenzoquinone-based photocage reveal impact cyclic ring size, steric substituent, and electronic substituent on individual uncaging ( k H2O dioxane ) polarity preference / ). Rational incorporation optimized moieties leads up 20.2-fold nonpolar kinetic selectivity Further photochemical spectroscopic characterizations theoretical calculations together uncover mechanism underlying polarity-dependent kinetics. The uncaged ortho-quinone methide product bears covalent reactivity nucleophiles protein revealed by tandem mass spectrometry. Finally, demonstrate application such lipophilic chemistry selective labeling profiling proteins proximity lipid droplets inside human fatty liver tissues. Together, this work studies effects adapts it suborganelle-targeted profiling.
Язык: Английский
Процитировано
0