Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 11, 2024
Abstract
Trivalent
phosphine
catalysis
is
mostly
utilized
to
activate
the
carbon‐carbon
multiple
bonds
form
carbanion
intermediate
species
and
highly
sensitive
certain
variables.
Random
manual
multi‐variables
are
critical
for
understanding
batch
disabled
regeneration
of
trivalent
chemistry.
We
need
artificial
intelligence‐based
system
which
can
change
variable
based
on
previously
conducted
failed
experiment.
Herein,
we
report
an
auto‐optimized
electro‐micro‐flow
reactor
platform
in‐situ
reduction
stable
P(V)
oxide
P(III)
further
method
Corey‐Fuchs
reaction.
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(23), С. 15850 - 15859
Опубликована: Май 28, 2024
Light-driven
strategies
that
enable
the
chemoselective
activation
of
a
specific
bond
in
multifunctional
systems
are
comparatively
underexplored
comparison
to
transition-metal-based
technologies,
yet
desirable
when
considering
controlled
exploration
chemical
space.
With
current
drive
discover
next-generation
therapeutics,
reaction
design
enables
strategic
incorporation
an
sp3
carbon
center,
containing
multiple
synthetic
handles
for
subsequent
space
would
be
highly
enabling.
Here,
we
describe
photoactivation
ambiphilic
C1
units
generate
α-bimetalloid
radicals
using
only
Lewis
base
and
light
source
directly
activate
C–I
bond.
Interception
these
transient
with
various
SOMOphiles
rapid
synthesis
organic
scaffolds
(B,
Si,
Ge)
orthogonal
activation.
In-depth
theoretical
mechanistic
studies
reveal
prominent
role
2,6-lutidine
forming
photoactive
charge
transfer
complex
stabilizing
situ
generated
iodine
radicals,
as
well
influential
boron
p-orbital
activation/weakening
This
simple
efficient
methodology
enabled
expedient
access
functionalized
3D
frameworks
can
further
derivatized
available
technologies
C–B
C–Si
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
This
study
describes
a
pioneering
visible-light-induced
phosphine-catalyzed
halogen-atom
transfer
(XAT)
strategy
that
heralds
new
era
in
the
difunctionalization
of
[1.1.1]propellane.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Июнь 25, 2024
Abstract
In
general,
the
P-centered
ring-opening
of
quaternary
phosphirenium
salts
(QPrS)
predominantly
leads
to
hydrophosphorylated
products,
while
C-centered
is
primarily
confined
intramolecular
nucleophilic
reactions,
resulting
in
formation
phosphorus-containing
cyclization
products
instead
difunctionalized
generated
through
intermolecular
processes.
Here,
promotion
three-member
rings
by
iodine
anions
and
quenching
electronegative
carbon
atoms
cations,
we
successfully
synthesize
β
-functionalized
vinylphosphine
oxides
P-addition
QPrS
intermediates
situ.
Multiple
β-
iodo-substituted
can
be
obtained
with
exceptional
regio-
stereo-selectivity
reacting
secondary
phosphine
unactivated
alkynes.
addition,
a
variety
converted
from
C-I
bonds,
especially
rapid
construction
benzo[
b
]phospholes
oxides,
demonstrates
significance
this
strategy.
Green Chemistry,
Год журнала:
2024,
Номер
26(18), С. 9749 - 9756
Опубликована: Янв. 1, 2024
A
novel
cobalt-catalyzed
radical
1,3-diphosphination
of
alkenes
was
developed,
which
enables
straightforward
access
to
1,3-diphosphine
skeleton
compounds
under
mild
conditions.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(8), С. 2161 - 2170
Опубликована: Янв. 1, 2024
A
base-induced
three-components
coupling
employing
unactivated
alkenes,
fluoroalkyl
iodides
and
diazonium
salts
under
mild
reaction
conditions
has
been
developed.
Organic Letters,
Год журнала:
2024,
Номер
26(8), С. 1739 - 1744
Опубликована: Фев. 17, 2024
A
general
catalytic
donor
for
the
combination
of
a
photoinduced
electron
donor–acceptor
(EDA)
complex
and
energy
transfer
was
developed.
This
mild
metal-free
protocol
allows
facile
access
to
various
Z-alkenes.
Mechanism
studies
revealed
that
organophotocatalyst,
4-CzIPN,
formed
distinct
three-component
EDA
with
redox-active
esters
(C6H5O)2P(O)OH
trigger
photoredox
catalysis.
The
E
→
Z
isomerization
achieved
via
exchange
from
4-CzIPN.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(17), С. 4748 - 4756
Опубликована: Янв. 1, 2024
Difunctionalizations
of
unactivated
olefins
with
fluoroalkyl
carboxylic
acids
or
aldehydes
via
a
radical-mediated
functional
group
migration
strategy
are
herein
reported.
