Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(9), С. 4102 - 4117
Опубликована: Июнь 12, 2024
Tumor
vaccine,
a
promising
modality
of
tumor
immunotherapy,
needs
to
go
through
the
process
antigen
generation
and
loading,
drainage
lymph
nodes
(LNs),
internalization
by
dendritic
cells
(DCs),
DC
maturation,
cross-presentation
activate
T-cells.
However,
vaccines
are
often
unable
satisfy
all
steps,
leading
limitation
their
application
efficacy.
Herein,
based
on
smart
nanogel
system,
an
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(4)
Опубликована: Ноя. 30, 2023
Abstract
Recently,
therapeutic
cancer
vaccines
have
emerged
as
promising
candidates
for
immunotherapy.
Nevertheless,
their
efficacies
are
frequently
impeded
by
challenges
including
inadequate
antigen
encapsulation,
insufficient
immune
activation,
and
immunosuppressive
tumor
microenvironment.
Herein,
we
report
a
three‐in‐one
hydrogel
assembled
nucleic
acids
(NAs)
that
can
serve
vaccine
to
in
situ
trigger
strong
response
against
cancer.
Through
site‐specifically
grafting
the
chemodrug,
7‐ethyl‐10‐hydroxycamptothecin
(also
known
SN38),
onto
three
component
phosphorothioate
(PS)
DNA
strands,
Y‐shaped
motif
(Y‐motif)
with
sticky
ends
is
self‐assembled,
at
one
terminus
of
which
an
unmethylated
cytosine‐phosphate‐guanine
(CpG)
segment
introduced
agonist.
Thereafter,
programmed
cell
death
ligand‐1
(PD‐L1)
siRNA
performs
checkpoint
inhibitor
designed
crosslinker
assemble
CpG‐
SN38‐containing
Y‐motif,
resulting
formation
final
NA
vaccine.
With
functional
agents
inside,
remarkably
induce
immunogenic
enhance
presentation,
promoting
dendritic
maturation
effector
T
lymphocyte
infiltration,
well
relieving
environment.
When
inoculated
twice
sites,
demonstrates
substantial
antitumor
effect
melanoma
mouse
model,
proving
its
potential
general
platform
synergistic
ACS Materials Letters,
Год журнала:
2024,
Номер
6(4), С. 1120 - 1129
Опубликована: Фев. 26, 2024
Vinylene-linked
covalent–oganic
frameworks
(COFs),
as
novel
photocatalysts,
have
garnered
considerable
attention
due
to
their
exceptional
stability,
remarkable
π-electron
delocalization,
and
precisely
customizable
structures.
However,
the
design
of
monomers
for
constructing
vinylene-linked
COFs
with
tunable
electronic
structures
is
still
in
its
early
stages
poses
a
number
challenges.
Addressing
this,
tritopic
monomer
was
developed
by
attaching
3-fold
2-methylpyridine
unit
triphenyl-1,3,5-triazine
core.
The
further
condensed
aromatic
dialdehydes
via
solid-state
Knoevenagel
polycondensation
reaction
form
two
2D
(TP-PB
TP-PT
COF),
which
exhibited
excellent
crystallinity,
preeminent
outstanding
delocalization.
More
importantly,
modulation
donor–acceptor
(D–A)
interaction
within
COFs,
semiconducting
properties
could
be
optimized.
Due
stronger
D–A
interactions
TP-PB
COF
containing
1,3,5-triphenylbenzene
than
unit,
broader
visible
light
absorption,
narrower
band
gap,
photocurrent
response,
lower
charge
transfer
resistance,
makes
more
efficient
photocatalyst
photocatalytic
selective
conversions
organic
sulfides
sulfoxides
C-3
thiocyanation
indole
derivatives
high
catalytic
activity
recyclability.
This
work
not
only
demonstrates
construction
but
also
presents
facile
strategy
regulating
such
fine-tuning
matrices.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(9), С. 4102 - 4117
Опубликована: Июнь 12, 2024
Tumor
vaccine,
a
promising
modality
of
tumor
immunotherapy,
needs
to
go
through
the
process
antigen
generation
and
loading,
drainage
lymph
nodes
(LNs),
internalization
by
dendritic
cells
(DCs),
DC
maturation,
cross-presentation
activate
T-cells.
However,
vaccines
are
often
unable
satisfy
all
steps,
leading
limitation
their
application
efficacy.
Herein,
based
on
smart
nanogel
system,
an
