Biocatalysis in Water or in Non-Conventional Media? Adding the CO2 Production for the Debate

Molecules, Год журнала: 2023, Номер 28(18), С. 6452 - 6452

Опубликована: Сен. 6, 2023

Biocatalysis can be applied in aqueous media and different non-aqueous solutions (non-conventional media). Water is a safe solvent, yet many synthesis-wise interesting substrates cannot dissolved solutions, thus low concentrations are often applied. Conversely, non-conventional may enable higher substrate loadings but at the cost of using (fossil-based) organic solvents. This paper determines CO2 production-expressed as kg CO2·kg product-1-of generic biotransformations water media, assessing both upstream downstream. The key to reaching diminished environmental footprint type wastewater treatment implemented. If used chemicals conventional (mild) treatment, production limited. other (pre)treatments for needed eliminate hazardous solvents, impacts expected (based on production). biocatalysis more sustainable during unit-the biocatalytic step-than systems. However, processes with need incorporate extractive solvents downstream processing. Both strategies result comparable if recycled least 1-2 times. Under these conditions, industrial biotransformation 100 g L-1 loading would produce 15-25 product-1 regardless media.

Язык: Английский

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API Syntheses in Aqueous Media: Assessing the Environmental Footprint en route from Academic Discovery to Industrial Applications as “Green Opportunity” for Process Chemistry

Organic Process Research & Development, Год журнала: 2023, Номер 27(5), С. 822 - 830

Опубликована: Май 1, 2023

The use of designer surfactants to facilitate chemical transformations in water is a prime example for the knowledge transfer from academia industry. Accordingly, chemistry aqueous media aided by has emerged as viable alternative organic solvents part effort transform manufacturing into green art. While classical metrics indicate tremendous savings on waste generation, more exhaustive analysis including intrinsic carbon footprint such never been conducted. present work addresses this topic and outlines case study widely known applied working-horse surfactant chemistry, TPGS-750-M. Meanwhile, fate employed considered, holistic comparison drawn. key streamlined assessment reflected proper metrics, clearly pointing out nonzero chemistries media, though techniques range at greener end scale reaction media.

Язык: Английский

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Gate to a parallel universe: utilization of biosurfactants in micellar catalysis

Green Chemistry, Год журнала: 2023, Номер 25(9), С. 3462 - 3468

Опубликована: Янв. 1, 2023

Aqueous solutions of biosurfactant rhamnolipids were utilized in micellar cross-coupling reactions as the reaction media for functionalization aromatic and heteroaromatic molecules, including bioactive compounds special fluorinated species.

Язык: Английский

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A tutorial review for research laboratories to support the vital path toward inherently sustainable and green synthetic chemistry

RSC Sustainability, Год журнала: 2024, Номер 2(3), С. 578 - 607

Опубликована: Янв. 1, 2024

Journeying towards inherently sustainable and green synthetic chemistry. Commitment to change (re)design of practices, processes goals, through reflection, awareness education.

Язык: Английский

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Chemoenzymatic total synthesis of alchivemycin A

Nature Synthesis, Год журнала: 2024, Номер 3(9), С. 1124 - 1133

Опубликована: Июнь 25, 2024

Язык: Английский

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Palladium-Catalyzed Aminations in Flow ... on Water

ACS Catalysis, Год журнала: 2024, Номер 14(3), С. 1545 - 1552

Опубликована: Янв. 16, 2024

Aminations can be efficiently run, under plug flow conditions on water, catalyzed by low levels of a recyclable palladium precatalyst. General protocols to couple amines, both aryl and aliphatic, with aryl/heteroaryl bromides have been developed. Further highlights include "on water" conditions, short reaction times, recycling the medium, residual Pd in isolated products, E factors as green metric, all these features showcasing this alternative amination reactions typically run batch mode.

Язык: Английский

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Saponin: A Green and Efficient Natural Surfactant for Suzuki-Miyaura Cross-Couplings of Heteroaryl Substrates in Aqueous Media at Ambient Conditions

Green Chemistry, Год журнала: 2024, Номер 26(3), С. 1393 - 1398

Опубликована: Янв. 1, 2024

Herein, we report a commercially available natural saponin acting as surfactant and serving micellar catalyst, enabling Suzuki–Miyaura cross-coupling effectively with highly challenging heteroaromatic substrates in water at room temperature.

Язык: Английский

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Merging High‐Pressure Syngas Metal Catalysis and Biocatalysis in Tandem One‐Pot Processes for the Synthesis of Nonchiral and Chiral Alcohols from Alkenes in Water

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(28)

Опубликована: Апрель 17, 2024

While simultaneously proceeding reactions are among the most fascinating features of biosynthesis, this concept tandem processes also offers high potential in chemical industry terms less waste production and improved process efficiency sustainability. Although examples one-pot chemoenzymatic syntheses exist, combination completely different reaction types is rare. Herein, we demonstrate that extreme "antipodes" "worlds catalysis", such as syngas-based high-pressure hydroformylation biocatalyzed reduction, can be combined within a tandem-type water. No significant deactivation was found for either biocatalyst or chemocatalyst. A proof-of-concept starting from 1-octene established with >99 % conversion 80 isolated yield desired alcohol isomers. All necessary components biocatalysis were added to reactor beginning. This has been extended enantioselective synthesis chiral products by conducting styrene an enzymatic dynamic kinetic resolution mode, leading excellent enantiomeric ratio 91 : 9 (S)-2-phenylpropanol. The overall runs water under mild energy-saving conditions, without any need intermediate isolation.

Язык: Английский

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Enzymatic reduction of halogenated aryl ketones in an aqueous micellar solution with enhanced catalytic performance

Green Chemistry, Год журнала: 2024, Номер 26(11), С. 6666 - 6674

Опубликована: Янв. 1, 2024

The synthesis of enantiopure chiral halogenated aryl alcohols by ketoreductases was conducted in an aqueous micellar solution formed TPGS-750-M, achieving remarkable yields and enantioselectivities under high concentration.

Язык: Английский

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Activation of fluoride anion as nucleophile in water with data-guided surfactant selection

Chemical Science, Год журнала: 2024, Номер 15(15), С. 5764 - 5774

Опубликована: Янв. 1, 2024

A principal component surfactant_map was developed for 91 commercially surfactants use in surfactant-enabled organic reactions water. The map led to activation of fluoride anion, usually strongly hydrated, as an active nucleophile

Язык: Английский

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