Photoinduced Selective B–H Activation of nido-Carboranes

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(11), С. 7791 - 7802

Опубликована: Март 10, 2024

The development of new synthetic methods for B–H bond activation has been an important research area in boron cluster chemistry, which may provide opportunities to broaden the application scope clusters. Herein, we present a reaction strategy direct site-selective functionalization nido-carboranes initiated by photoinduced cage via noncovalent cage···π interaction. As result, nido-carborane radical is generated through single electron transfer from 3D 2D photocatalyst upon irradiation with green light. resulting transient could be directly probed advanced time-resolved EPR technique. In air, subsequent transformations active have led efficient and selective B–N, B–S, B–Se couplings presence N-heterocycles, imines, thioethers, thioamides, selenium ethers. This protocol also facilitates both late-stage modification drugs synthesis nido-carborane-based drug candidates neutron capture therapy (BNCT).

Язык: Английский

---

Facile synthesis of the dodecahydridododecaborate (B12H122−) from borane Lewis base adducts

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Язык: Английский

---

Dative Bonding Activation Enables Precise Functionalization of the Remote B–H Bond of nido-Carborane Clusters

Journal of the American Chemical Society, Год журнала: 2024, Номер unknown

Опубликована: Сен. 13, 2024

The innovation of synthetic strategies for selective B-H functionalization is a pivotal objective in the realm boron cluster chemistry. However, precise, efficient, and rapid bond carboranes that distant from existing functional groups remains intractable owing to limited approaches site-selective control established methods. Herein, we report dative bonding activation strategy nonclassical remote site

Язык: Английский

---

A strategy for regioselective B–H functionalization ofo-carboranesviabase metal catalysis

Organic Chemistry Frontiers, Год журнала: 2023, Номер 10(12), С. 3074 - 3079

Опубликована: Янв. 1, 2023

This frontier article summarizes the recent developments in base metal-catalyzed regioselective cage B–H functionalization of carboranes and discusses related challenging issues.

Язык: Английский

---

Palladium-Catalyzed Cross-Coupling Reactions of Carboranes with Alkenes via Selective B–H Bond Activation

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

A palladium-catalyzed Heck-type cross-coupling reaction of carboranes with alkenes in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) was realized. This shows good B(9) selectivity for m-carboranes and is also suitable o- p-carborane. Meanwhile, a series mono-, di-, trisubstituted were compatible substrates to afford the alkenylated products 16–89% yields. The 1,2-bis(carboranyl)ethylene first synthesized by vinyltrimethylsilane m-carborane. Further transformations C═C bond product examined hydroboration oxidation, hydroboration, bromination generate corresponding B(9)-functionalized m-carboranes.

Язык: Английский

---

Taming Inert B–H Bond with Low Energy Light: A Near-Infrared Light-Induced Approach to Facile Carborane Cluster-Amino Acid Coupling

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

The selective functionalization of inert B–H bonds in carborane clusters has been a formidable challenge. Recent advances have witnessed such reactions through photoredox methods utilizing ultraviolet or visible light irradiation. However, high-energy sources often suffer from poor energy efficiency, limited substrate scope, undesired side reactions, and low scalability. Here, we present the first successful bond under low-energy near-infrared (NIR) using carborane-based electron donor–acceptor complex. Both photophysical investigations theoretical modeling reveal facile single-electron transfer cage to electron-deficient photocatalyst, generating radical NIR follow-up pathway enables direct coupling carboranes with amino acids oligopeptides, yielding diverse array carborane-functionalized oligopeptides. Beyond expanding known chemical space boron cluster derivatives, further demonstrate that imaging targeting capabilities could serve as promising multifunctional carriers for neutron capture therapy. Thus, via not only provides straightforward practical strategy synthetic chemistry but also lays foundation development next-generation boron-containing biomolecules advanced functional materials.

Язык: Английский

---

Polyoxometalate-Supported Pd(II)-Catalyzed B(9)–H Nitration of o/m-Carboranes

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 7646 - 7652

Опубликована: Апрель 23, 2025

Язык: Английский

---

Post-coordination of Ru(II) Controlled Regioselective B(4)–H Acylmethylation of o-Carboranes with Sulfoxonium Ylides

Chemical Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Despite significant progress in the B-H functionalization of carboranes, development cost-effective catalytic systems devoid noble metals, coupled with mechanistic validation regioselectivity control, remains a formidable challenge. Herein, we disclose an Ag salt-free, redox-neutral, and inexpensive ruthenium(ii)-catalyzed protocol that enables exclusive B(4)-H acylmethylation o-carboranes through novel post-coordination strategy. By exploiting weakly coordinating carboxylic acid as traceless directing group, this method achieves excellent mono-site selectivity for B-C(sp3) bond formation using diverse sulfoxonium ylides, demonstrating both functional group tolerance synthetic scalability. This work not only establishes practical platform but also addresses critical questions unresolved prior analogous studies. Through deuterium labeling, situ high-resolution mass spectrometry (HRMS) tracking, single-crystal X-ray analysis Ru intermediates, unequivocally demonstrate originates from unique mode Ru(ii). The catalyst simultaneously engages enolizable acylmethyl moiety mono-acylated intermediate, thereby dictating activation trajectory. Our findings establish generalizable regiocontrolled carborane while defining paradigms transition metal-mediated chemistry.

Язык: Английский

---

Reaction of Carboranyl Lithium and 2,3-Dichloroquinoxaline to Synthesize Carborane-Fused N-Heteroaromatic

Organometallics, Год журнала: 2024, Номер 43(10), С. 1077 - 1084

Опубликована: Май 16, 2024

Nucleophilic substitution of B–H is an important strategy for the synthesis carborane derivatives. Although intermolecular nucleophilic has been widely explored, intramolecular rarely reported. Herein, we synthesized a novel carborane-fused N-heteroaromatic through transition-metal-free reaction between carboranyl lithium and 2,3-dichloroquinoxaline. Two C–Cl substitutions one with were involved in this transformation. Instead most electron-deficient B(3)–H vertex, selectively occurred on B(4)–H vertex. This method provides new ring compounds.

Язык: Английский

---

A variable bidentate traceless directing group for nickel-catalyzed regioselective B–H poly-chalcogenation of o-carboranes

Inorganic Chemistry Frontiers, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A nickel-catalyzed direct cage B–H poly-chalcogenation of icosahedral carborane clusters, enabled by a variable bidentate 8-aminoquinoline traceless directing group, has been developed under oxidant-free and weakly basic conditions.

Язык: Английский

---